Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)
Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...
Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...
Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)
Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...
Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...
Furst, Daniel E, Breedveld, F C, Kalden, J R, Smolen, J S, Burmester, G R, Bijlsma, JWJ, ...
As in previous years, the consensus group to consider the use of biological agents was constituted by rheumatologists from the Universities of Erlangen, Leiden, and Vienna in Europe in cooperation...
Swaak, A.J., Moutsopoulos, H.M., Dratwianka, B., Kalden, J.R., Tosi, S., Marchesoni, A., ...
OBJECTIVE: Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus (SLE). The aim...
Swaak, A.J., Rozman, B., Chwalinska-Sadowska, H, Bombardieri, S., Kovacs, A., Schneider, M., ...
OBJECTIVE: Most information available about the disease course of patients with systemic lupus erythematosus (SLE) is restricted to the first 5 yr after disease onset. Data about the disease course...
Range of antinuclear antibodies in "healthy" individuals (1997)
Tan, E.M., Feltkamp, T.E.W., Smolen, J.S., Dawkins, R., Fritzler, M.J., Gordon, T., ...
Steiner, G, Hartmuth, K, Skriner, K, Maurer-Fogy, I, Sinski, A, Thalmann, E, ...
RA33 is a nuclear autoantigen with an apparent molecular mass of 33 kD. Autoantibodies against RA33 are found in about 30% of sera from RA patients, but only occasionally in sera from patients with...
Responder cells in the human autologous mixed lymphocyte reaction.
Smolen, J S, Luger, T A, Chused, T M, Steinberg, A D
Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells...
Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture.
Luger, T A, Smolen, J S, Chused, T M, Steinberg, A D, Oppenheim, J J
In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A)...
Smolen, J S, Bettelheim, P, Köller, U, McDougal, S, Graninger, W, Luger, T A, ...
14 patients with hemophilia were studied for the distribution of T cell subsets, the presence of antibody to lymphadenopathy-associated or human T lymphotropic virus type III (LAV/HTLV-III), and...
Skriner, K, Sommergruber, W H, Tremmel, V, Fischer, I, Barta, A, Smolen, J S, ...
The recently described anti-A2/RA33 autoantibodies occur in 20-40% of patients with RA, SLE, and mixed connective tissue disease (MCTD). They are directed to the A2 protein of the heterogeneous...
Steiner, G, Hartmuth, K, Skriner, K, Maurer-Fogy, I, Sinski, A, Thalmann, E, ...
RA33 is a nuclear autoantigen with an apparent molecular mass of 33 kD. Autoantibodies against RA33 are found in about 30% of sera from RA patients, but only occasionally in sera from patients with...
Responder cells in the human autologous mixed lymphocyte reaction.
Smolen, J S, Luger, T A, Chused, T M, Steinberg, A D
Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells...
Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture.
Luger, T A, Smolen, J S, Chused, T M, Steinberg, A D, Oppenheim, J J
In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A)...
Smolen, J S, Bettelheim, P, Köller, U, McDougal, S, Graninger, W, Luger, T A, ...
14 patients with hemophilia were studied for the distribution of T cell subsets, the presence of antibody to lymphadenopathy-associated or human T lymphotropic virus type III (LAV/HTLV-III), and...
Skriner, K, Sommergruber, W H, Tremmel, V, Fischer, I, Barta, A, Smolen, J S, ...
The recently described anti-A2/RA33 autoantibodies occur in 20-40% of patients with RA, SLE, and mixed connective tissue disease (MCTD). They are directed to the A2 protein of the heterogeneous...
Smolen, J S, Klippel, J H, Penner, E, Reichlin, M, Steinberg, A D, Chused, T M, ...
HLA-DR antigens and autoantibodies to the nuclear or cytoplasmic antigens Ro/SSA, La/SSB, Sm, and RNP were determined in North American and Austrian patients with systemic lupus erythematosus (SLE)....
Serum osteocalcin concentrations in patients with rheumatoid arthritis.
Pietschmann, P, Machold, K P, Wolosczuk, W, Smolen, J S
Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are...
Machold, K P, Neumann, K, Smolen, J S
Interferon gamma (IFN gamma) has been advocated in open studies as a beneficial remission inducing drug for the treatment of rheumatoid arthritis (RA). The work reported here was designed to assess...
Vitali, C, Bombardieri, S, Moutsopoulos, H M, Coll, J, Gerli, R, Hatron, P Y, ...
OBJECTIVE: To assess the recently proposed preliminary criteria for the classification of Sjögren's syndrome (SS) in a multicentre European study of a new series of clinically defined cases....
Stingl, L A, Sinska, A, Landesmann, U, Smolen, J S
In this study, we sought to elucidate the sequence of events by which mitogenic monoclonal anti-CD3 antibodies (anti-CD3-MoAb) initiate T cell activation. In cultures of monocyte-depleted resting T...
Kindås-Mügge, I, Steiner, G, Smolen, J S
Stress or heat-shock proteins may be involved in the initiation and perpetuation of autoimmune diseases. In order to investigate a possible role of autoantibodies against the 70-kD family of...
KÖLLER, M D, KIENER, H P, ARINGER, M, GRANINGER, W B, MEUER, S, SAMSTAG, Y, ...
Defects of T cell (Tc) proliferation have been demonstrated in several autoimmune diseases. Detailed mechanisms governing activation and proliferation of Tc are still not completely known. Here we...