Polynitrosylated proteins: characterization, bioactivity, and functional consequences.
Simon, D I, Mullins, M E, Jia, L, Gaston, B, Singel, D J, Stamler, J S
Chemical modification of proteins is a common theme in their regulation. Nitrosylation of protein sulfhydryl groups has been shown to confer nitric oxide (NO)-like biological activities and to...
Asano, K, Chee, C B, Gaston, B, Lilly, C M, Gerard, C, Drazen, J M, ...
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in human lung epithelium. However, the molecular nature of NOS and the...
Stamler, J S, Simon, D I, Osborne, J A, Mullins, M E, Jaraki, O, Michel, T, ...
Endothelium-derived relaxing factor (EDRF) activity has been attributed to the highly labile nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain reactive...
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J S, Jaraki, O, Osborne, J, Simon, D I, Keaney, J, Vita, J, ...
We have recently shown that nitric oxide or authentic endothelium-derived relaxing factor generated in a biologic system reacts in the presence of specific protein thiols to form S-nitrosoprotein...
Stamler, J S, Simon, D I, Jaraki, O, Osborne, J A, Francis, S, Mullins, M, ...
Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme's single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol...
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Keaney, J F, Simon, D I, Stamler, J S, Jaraki, O, Scharfstein, J, Vita, J A, ...
Recent evidence suggests that sulfhydryl species can react with oxides of nitrogen under physiologic conditions and thereby stabilize endothelium-derived relaxing factor (EDRF) activity, but the...
Slivka, A, Chuttani, R, Carr-Locke, D L, Kobzik, L, Bredt, D S, Loscalzo, J, ...
Nitric oxide (NO) is an inhibitor of gastrointestinal smooth muscle. Model systems of the gut predict the NO will complex with biological thiol (SH) groups, yielding S-nitrosothiols (RS-NO), which...
Scharfstein, J S, Keaney, J F, Slivka, A, Welch, G N, Vita, J A, Stamler, J S, ...
Plasma albumin reacts with nitric oxide (NO) to form the bioactive adduct, S-nitroso-albumin (S-NO-albumin). The limited intracellular access of S-NO-albumin suggests the need for a vascular transfer...
Stamler, J S, Osborne, J A, Jaraki, O, Rabbani, L E, Mullins, M, Singel, D, ...
Elevated levels of homocysteine are associated with an increased risk of atherosclerosis and thrombosis. The reactivity of the sulfhydryl group of homocysteine has been implicated in molecular...
Polynitrosylated proteins: characterization, bioactivity, and functional consequences.
Simon, D I, Mullins, M E, Jia, L, Gaston, B, Singel, D J, Stamler, J S
Chemical modification of proteins is a common theme in their regulation. Nitrosylation of protein sulfhydryl groups has been shown to confer nitric oxide (NO)-like biological activities and to...
Asano, K, Chee, C B, Gaston, B, Lilly, C M, Gerard, C, Drazen, J M, ...
Histochemical activity and immunoreactivity of nitric oxide synthase (NOS, EC 1.14.13.39) have been recently demonstrated in human lung epithelium. However, the molecular nature of NOS and the...
Stamler, J S, Simon, D I, Osborne, J A, Mullins, M E, Jaraki, O, Michel, T, ...
Endothelium-derived relaxing factor (EDRF) activity has been attributed to the highly labile nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain reactive...
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J S, Jaraki, O, Osborne, J, Simon, D I, Keaney, J, Vita, J, ...
We have recently shown that nitric oxide or authentic endothelium-derived relaxing factor generated in a biologic system reacts in the presence of specific protein thiols to form S-nitrosoprotein...
Stamler, J S, Simon, D I, Jaraki, O, Osborne, J A, Francis, S, Mullins, M, ...
Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme's single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol...
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Keaney, J F, Simon, D I, Stamler, J S, Jaraki, O, Scharfstein, J, Vita, J A, ...
Recent evidence suggests that sulfhydryl species can react with oxides of nitrogen under physiologic conditions and thereby stabilize endothelium-derived relaxing factor (EDRF) activity, but the...
Slivka, A, Chuttani, R, Carr-Locke, D L, Kobzik, L, Bredt, D S, Loscalzo, J, ...
Nitric oxide (NO) is an inhibitor of gastrointestinal smooth muscle. Model systems of the gut predict the NO will complex with biological thiol (SH) groups, yielding S-nitrosothiols (RS-NO), which...
Scharfstein, J S, Keaney, J F, Slivka, A, Welch, G N, Vita, J A, Stamler, J S, ...
Plasma albumin reacts with nitric oxide (NO) to form the bioactive adduct, S-nitroso-albumin (S-NO-albumin). The limited intracellular access of S-NO-albumin suggests the need for a vascular transfer...
Stamler, J S, Osborne, J A, Jaraki, O, Rabbani, L E, Mullins, M, Singel, D, ...
Elevated levels of homocysteine are associated with an increased risk of atherosclerosis and thrombosis. The reactivity of the sulfhydryl group of homocysteine has been implicated in molecular...
Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients.
Rachmilewitz, D, Karmeli, F, Eliakim, R, Stalnikowicz, R, Ackerman, Z, Amir, G, ...
Nitric oxide, the product of nitric oxide synthase in inflammatory cells, may have a role in tissue injury through its oxidative metabolism. Nitric oxide may have a role in the pathogenesis of...
Rachmilewitz, D, Stamler, J S, Bachwich, D, Karmeli, F, Ackerman, Z, Podolsky, D K
Recent studies have suggested that nitric oxide (NO.), the product of nitric oxide synthase in inflammatory cells, may play a part in tissue injury and inflammation through its oxidative metabolism....