Notch1 can contribute to viral-induced transformation of primary human keratinocytes (2008)
Lathion, S., Schaper, J., Beard, P., Raj, K.
The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform...
Nef, H. M., Mollmann, H., Troidl, C., Kostin, S., Bottger, T., Voss, S., ...
Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction, but its specific pathomechanism remains unknown. Thus, we performed a systematic expression profiling of genes...
Weber, C., Schaper, J., Tibussek, D., Adams, O., Mackenzie, C. R., Dilloo, D., ...
Neurological complications are a relevant cause of morbidity and mortality after haematopoietic stem cell transplantation (SCT). We retrospectively analysed neurological complications of 165...
Knoll, R., Postel, R., Wang, J., Kratzner, R., Hennecke, G., Vacaru, A. M., ...
BACKGROUND: Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
Bone marrow-derived cells contribute to infarct remodelling (2006)
Mollmann, H., Nef, H. M., Kostin, S., Von Kalle, C., Pilz, I., Weber, M., ...
OBJECTIVE: The paradigm that cardiac myocytes are non-proliferating and terminally differentiated cells has recently been challenged by several studies reporting the ability of bone marrow-derived...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
beta-ureidopropionase deficiency presenting with febrile status epilepticus (2006)
Assmann, B.E., Distelmaier, F., Rosenbaum, T., Schaper, J., ...
Apoptosis: measurement and technical issues (2005)
In this short review article we discuss the many uncertainties with the estimation of the relevance of data on the rate of apoptotic cell death in the myocardium. 1. The time course and duration of...
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B. R., Schaper, J.
In this study we tested our previous hypothesis that ischemia is a multifactorial injurious event involving all components of the myocyte simultaneously. This hypothesis was based on ultrastructural...
Schwarz, E. R., Gupta, R., Diep, T. P., Nowak, B., Kostin, S., Grohmann, B., ...
BACKGROUND: We tested the hypothesis of whether carvedilol delays morphologic degeneration and improves functional outcome compared with metoprolol tartrate in patients with hibernating myocardium...
Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes (2005)
Zeevi-Levin, N., Barac, Y. D., Reisner, Y., Reiter, I., Yaniv, G., Meiry, G., ...
OBJECTIVES: Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes (2005)
Zeevi-Levin, N., Barac, Y. D., Reisner, Y., Reiter, I., Yaniv, G., Meiry, G., ...
OBJECTIVES: Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested...
Schwarz, E. R., Gupta, R., Diep, T. P., Nowak, B., Kostin, S., Grohmann, B., ...
BACKGROUND: We tested the hypothesis of whether carvedilol delays morphologic degeneration and improves functional outcome compared with metoprolol tartrate in patients with hibernating myocardium...
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B. R., Schaper, J.
In this study we tested our previous hypothesis that ischemia is a multifactorial injurious event involving all components of the myocyte simultaneously. This hypothesis was based on ultrastructural...
Apoptosis: measurement and technical issues (2005)
In this short review article we discuss the many uncertainties with the estimation of the relevance of data on the rate of apoptotic cell death in the myocardium. 1. The time course and duration of...
Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart (2005)
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B.R., Schaper, J.
Toyo-Oka, T., Kawada, T., Nakata, J., Xie, H., Urabe, M., Masui, F., ...
Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death (2004)
Elsaesser, A., Vogt AM, Nef, H.M., Kostin, S., Mollmann, H., Skwara, W., ...
The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction (2004)
Haase, H., Pagel, I., Khalina, Y., Zacharzowsky, U., Person, V., Lutsch, G., ...
Polyakova, V., Hein, S., Kostin, S., Ziegelhoeffer, T., Schaper, J.
OBJECTIVES: We studied the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in fibrosis formation in the transition from hypertrophy to heart failure (HF) as well as the...
Toyo-Oka, T., Kawada, T., Nakata, J., Xie, H., Urabe, M., Masui, F., ...
Remodeling of the adventitia during coronary arteriogenesis (2003)
Cai, W. J., Koltai, S., Kocsis, E., Scholz, D., Kostin, S., Luo, X., ...
We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic occlusion of the left circumflex coronary...
Hein, S., Arnon, E., Kostin, S., Schonburg, M., Elsasser, A., Polyakova, V., ...
BACKGROUND: The progression of compensated hypertrophy to heart failure (HF) is still debated. We investigated patients with isolated valvular aortic stenosis and differing degrees of left...
Myocytes die by multiple mechanisms in failing human hearts (2003)
Kostin, S., Pool, L., Elsasser, A., Hein, S., Drexler, H. C., Arnon, E., ...
We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanisms: apoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 patients with idiopathic...
Gap junction remodeling and altered connexin43 expression in the failing human heart (2003)
Kostin, S., Rieger, M., Dammer, S., Hein, S., Richter, M., Klovekorn, W. P., ...
Gap junctions (GJ) are important determinants of cardiac conduction and the evidence has recently emerged that altered distribution of these junctions and changes in the expression of their...
Martire, A., Fernandez, B., Buehler, A., Strohm, C., Schaper, J., Zimmermann, R., ...
OBJECTIVE AND METHODS: Although a beneficial association between innate immunity and ischemic preconditioning has recently been proposed, the mechanisms responsible for this link are poorly...
Regulation of EMAP II by hypoxia (2003)
Matschurat, S., Knies, U. E., Person, V., Fink, L., Stoelcker, B., Ebenebe, C., ...
Endothelial-monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for monocytes and granulocytes. We have previously shown that EMAP II mRNA is strongly...
Functional disturbances due to structural remodelling in the failing human heart (2002)
Hein, S., Elsässer, A., Kostin, S., Zimmermann, R., Schaper, J.
Structural correlate of atrial fibrillation in human patients (2002)
Kostin, S., Klein, G., Szalay, Z., Hein, S., Bauer, E.P., Schaper, J.
Changes in the preserved heart that limit the length of preservation (2002)
Masters, J.N., Fokin, A.A., Schaper, J., Pool, L., Gong, G., Robicsek, F.
Structural remodelling in heart failure (2002)
Schaper, J., Kostin, S., Hein, S., Elsässer, A., Arnon, E., Zimmermann, R.
Vogt, A.M., Nef, H., Schaper, J., Poolman, M., Fell, D.A., Kübler, W., ...
Modelling Daily Runoff From Snow And Glacier Melt Using Remote Sensing Data (2000)
In this paper we present runoff simulations for snow and icemelt for the basins of Rhine-Felsberg, RhneSion and Ticino-Bellinzona. We use high resolution multispectral remote sensing data to map snow...
Bandow, U., Einfeld, D., Hezel, T., Moser, H. O., Rossmanith, R., Schaper, J.
Third order tracking calculations show that a wavelength shifter on the basis of a commercially available 12 T split-pair solenoid is compatible with the ANKA storage ring
A pure insertion device synchrotron light source utilizing the MBA-optics (1994)
Einfeld, D., Schaper, J., Plesko, M.
The pure insertion device (PID) lattice is a novel concept for a sinchrotron light source, where all possible light ports are irradiated by insertion devices. Up to 40% of the ring circumference is...
A pure insertion device synchrotron light source utilizing the MBA-optics (1994)
Einfeld, D., Schaper, J., Plesko, M.
The pure insertion device (PID) lattice is a novel concept for a sinchrotron light source, where all possible light ports are irradiated by insertion devices. Up to 40% of the ring circumference is...
A pure insertion device synchrotron light source utilizing the MBA-optics (1994)
Einfeld, D., Schaper, J., Plesko, M.
The pure insertion device (PID) lattice is a novel concept for a sinchrotron light source, where all possible light ports are irradiated by insertion devices. Up to 40% of the ring circumference is...
Ein Fall von Diabetes mellitus entstanden durch Trauma. (1873)
Dissertation--Göttingen.
Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb.
Arras, M, Ito, W D, Scholz, D, Winkler, B, Schaper, J, Schaper, W
We have previously shown that monocytes adhere to the vascular wall during collateral vessel growth (arteriogenesis) and capillary sprouting (angiogenesis). In this study we investigated the...
Structural organization and chromosomal localization of the mouse collagenase type I gene.
Schorpp, M, Mattei, M G, Herr, I, Gack, S, Schaper, J, Angel, P
A clone containing genomic sequences of part of the murine collagenase type 1 (MMP-1) gene was isolated. It contains exons 1-6 encoding all the domains required for collagenase function and 9 kb of...
Genotypic and Phenotypic Spectrum in Tricho-Rhino-Phalangeal Syndrome Types I and III
Schaper, J., Meinecke, P., Momeni, P., Groß, S., Von Holtum, D., ...
Tricho-rhino-phalangeal syndrome (TRPS) is characterized by craniofacial and skeletal abnormalities. Three subtypes have been described: TRPS I, caused by mutations in the TRPS1 gene on chromosome 8;...