Gazzinelli, R T, Leme, V M, Cancado, J R, Gazzinelli, G, Scharfstein, J
Trypanosoma cruzi antigenic specificities involved in human T-cell and antibody responses were compared in chronic chagasic patients affected with cardiomyopathy (C) or with the indeterminate form...
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Keaney, J F, Simon, D I, Stamler, J S, Jaraki, O, Scharfstein, J, Vita, J A, ...
Recent evidence suggests that sulfhydryl species can react with oxides of nitrogen under physiologic conditions and thereby stabilize endothelium-derived relaxing factor (EDRF) activity, but the...
Induction of the acute-phase protein serum amyloid P in experimental Chagas' disease.
Scharfstein, J, Barcinski, M A, Leon, L L
Serum amyloid P protein (SAP), which shares several structural properties with C-reactive protein, has been recently identified as an acute-phase reactant in mice. In this study, the systemic...
Human C4-binding protein. Association with immune complexes in vitro and in vivo.
Scharfstein, J, Correa, E B, Gallo, G R, Nussenzweig, V
C4-binding protein (bp), a glycoprotein with specific binding affinity for the activated form of C4 (C4b), has recently been isolated from human serum and partially characterized. This report...
Serveau, C, Lalmanach, G, Juliano, M A, Scharfstein, J, Juliano, L, Gauthier, F
A panel of intramolecularly quenched fluorogenic substrates containing the conserved QVVA and LVG inhibitory sequences of cystatin inhibitors was used to describe the specificity of the major...
Lalmanach, G, Mayer, R, Serveau, C, Scharfstein, J, Gauthier, F
Biotin-labelled peptidyl diazomethane inhibitors of cysteine proteinases, based on the N-terminal substrate-like segment of human cystatin C, a natural inhibitor of cysteine proteinases, were...
Nery, E D, Juliano, M A, Meldal, M, Svendsen, I, Scharfstein, J, Walmsley, A, ...
The substrate specificity of the major cysteinyl proteinase of the parasitic protozoan Trypanosoma cruzi (cruzipain) was investigated, by combinatorial replacement of amino acid residues at positions...
Gazzinelli, R T, Leme, V M, Cancado, J R, Gazzinelli, G, Scharfstein, J
Trypanosoma cruzi antigenic specificities involved in human T-cell and antibody responses were compared in chronic chagasic patients affected with cardiomyopathy (C) or with the indeterminate form...
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Keaney, J F, Simon, D I, Stamler, J S, Jaraki, O, Scharfstein, J, Vita, J A, ...
Recent evidence suggests that sulfhydryl species can react with oxides of nitrogen under physiologic conditions and thereby stabilize endothelium-derived relaxing factor (EDRF) activity, but the...
Induction of the acute-phase protein serum amyloid P in experimental Chagas' disease.
Scharfstein, J, Barcinski, M A, Leon, L L
Serum amyloid P protein (SAP), which shares several structural properties with C-reactive protein, has been recently identified as an acute-phase reactant in mice. In this study, the systemic...
Human C4-binding protein. Association with immune complexes in vitro and in vivo.
Scharfstein, J, Correa, E B, Gallo, G R, Nussenzweig, V
C4-binding protein (bp), a glycoprotein with specific binding affinity for the activated form of C4 (C4b), has recently been isolated from human serum and partially characterized. This report...
Serveau, C, Lalmanach, G, Juliano, M A, Scharfstein, J, Juliano, L, Gauthier, F
A panel of intramolecularly quenched fluorogenic substrates containing the conserved QVVA and LVG inhibitory sequences of cystatin inhibitors was used to describe the specificity of the major...
Lalmanach, G, Mayer, R, Serveau, C, Scharfstein, J, Gauthier, F
Biotin-labelled peptidyl diazomethane inhibitors of cysteine proteinases, based on the N-terminal substrate-like segment of human cystatin C, a natural inhibitor of cysteine proteinases, were...
Nery, E D, Juliano, M A, Meldal, M, Svendsen, I, Scharfstein, J, Walmsley, A, ...
The substrate specificity of the major cysteinyl proteinase of the parasitic protozoan Trypanosoma cruzi (cruzipain) was investigated, by combinatorial replacement of amino acid residues at positions...
Human C4-binding protein. I. Isolation and characterization
Scharfstein, J, Ferreira, A, Gigli, I, Nussenzweig, V
C4-binding protein (C4-bp), a new component of the complement system, was isolated from human plasma by precipitation with polyethyleneglycol, followed by chromatography on ion exchangers. C4-bp was...
The role of conserved residues of chagasin in the inhibition of cysteine peptidases
Smith, B.O., Santos, C.C., Costa, T.F.R., Scharfstein, J., Coombs, G.H., ...
We have evaluated the roles of key amino acids to the action of the natural inhibitor chagasin of papain-family cysteine peptidases. A W93A substitution decreased inhibitor affinity for human...