J. Schletter

The Internalization Time Course of a Given Lipopolysaccharide Chemotype Does Not Correspond to Its Activation Kinetics in Monocytes

Lentschat, A., El-Samalouti, V. T., Schletter, J., Kusumoto, S., Brade, L., Rietschel, E. T., ...

The prerequisites for the initiation of pathophysiological effects of endotoxin (lipopolysaccharide [LPS]) include binding to and possibly internalization by target cells. Monocytes/macrophages are...

Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein.

Schletter, J, Brade, H, Brade, L, Krüger, C, Loppnow, H, Kusumoto, S, ...

Activation of cells by bacterial lipopolysaccharide (LPS) plays a key role in the pathogenesis of gram-negative septic shock. The 55-kDa glycoprotein CD14 is known to bind LPS and initiate cell...

Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes.

Weidemann, B, Schletter, J, Dziarski, R, Kusumoto, S, Stelter, F, Rietschel, E T, ...

Previously, we were able to show that soluble peptidoglycan (sPG)-induced monokine production in human peripheral monocytes is inhibited by anti-CD14 monoclonal antibodies and by lipid A partial...

The Internalization Time Course of a Given Lipopolysaccharide Chemotype Does Not Correspond to Its Activation Kinetics in Monocytes

Lentschat, A., El-Samalouti, V. T., Schletter, J., Kusumoto, S., Brade, L., Rietschel, E. T., ...

The prerequisites for the initiation of pathophysiological effects of endotoxin (lipopolysaccharide [LPS]) include binding to and possibly internalization by target cells. Monocytes/macrophages are...

Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein.

Schletter, J, Brade, H, Brade, L, Krüger, C, Loppnow, H, Kusumoto, S, ...

Activation of cells by bacterial lipopolysaccharide (LPS) plays a key role in the pathogenesis of gram-negative septic shock. The 55-kDa glycoprotein CD14 is known to bind LPS and initiate cell...

Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes.

Weidemann, B, Schletter, J, Dziarski, R, Kusumoto, S, Stelter, F, Rietschel, E T, ...

Previously, we were able to show that soluble peptidoglycan (sPG)-induced monokine production in human peripheral monocytes is inhibited by anti-CD14 monoclonal antibodies and by lipid A partial...