Encouraging Role Based Online Learning Environments (2007)
Wills, S., Devonshire, E., Leigh, E., Rosser, E., Shepherd, J., Vincent, A.
This paper reports on progress in the first year of a two year project called Project EnROLE (Encouraging Role Based Online Learning Environments) which is funded by the Carrick Institute for...
Encouraging Role Based Online Learning Environments (2007)
Wills, S., Devonshire, E., Leigh, E., Rosser, E., Shepherd, J., Vincent, A.
This paper reports on progress in the first year of a two year project called Project EnROLE (Encouraging Role Based Online Learning Environments) which is funded by the Carrick Institute for...
Telomere length, risk of coronary heart disease and statin treatment. (2007)
Brouilette, S.W., Moore, J.S., McMahon, A.D., Thompson, J.R., Ford, I., Shepherd, J., ...
Encouraging Role Based Online Learning Environments (2007)
Wills, S., Devonshire, E., Leigh, E., Rosser, E., Shepherd, J., Vincent, A.
This paper reports on progress in the first year of a two year project called Project EnROLE (Encouraging Role Based Online Learning Environments) which is funded by the Carrick Institute for...
Shepherd, J., Langley, G.J., Herniman, J.M., Kilburn, J.D.
Split-and-mix peptide libraries have been encoded by capping cleavable, laddered sequences with p-bromobenzoic acid, allowing rapid analysis of the cleaved ladder fragments by mass spectrometry. The...
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia (2006)
Druker, B. J., Guilhot, F., O'Brien, S. G., Gathmann, I., Kantarjian, H., Gattermann, N., ...
Deedwania, P., Barter, P., Carmena, R., Fruchart, J.C., Grundy, S.M., Haffner, S., ...
Background Despite the prognostic value of metabolic syndrome for predicting cardiovascular events, few trials have investigated the effects of statin therapy on cardiovascular morbidity and...
The purpose of this study is to examine the claim that an infant's ability to respond appropriately to an emotional situation varies according to the emotional state of the mother. Surprise...
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia (2006)
Druker, B. J., Guilhot, F., O'Brien, S. G., Gathmann, I., Kantarjian, H., Gattermann, N., ...
Researcher calls for teaching tailored to student diversity (2005)
Press release announcing details of the funding made to six widening participation projects for the TLRP.
Third molar treatment outcome: a comparison of patients' preferences in Sweden and Wales. (2005)
Liedholm, R, Knutsson, K, Lysell, L, Rohlin, M, Brickley, M, Shepherd, J
Abstract is not available
Third Molar Treatment Outcome: A Comparison of Patients’ Preferences in Sweden and Wales. (2005)
Liedholm, Rolf, Lysell, L, Rohlin, Madeleine, Brickley, M, Shepherd, J, Knutsson, K
Aim: To elucidate and compare patients’ outcome preferences with regard to removal and retention of mandibular third molars in Sweden and Wales. Subjects and Method: The subjects comprised patients...
Intensive lipid lowering with atorvastatin in patients with stable coronary disease (2005)
LaRosa, J.C., Grundy, S.M., Waters, D.D., Shear, C., Barter, P., Fruchart, J.C., ...
Holt, B. Van Der, Verhoef, G.E., Ferrant, A., Fey, M.F., Crump, M., Theobald, M., ...
To determine whether MDR1 reversal by the addition of the P-glycoprotein (P-gp) inhibitor PSC-833 to standard induction chemotherapy would improve event-free survival (EFS), 419 untreated patients...
Tonelli, M, Isles, C, Craven, T, Tonkin, A, Pfeffer, MA, Shepherd, J, ...
Background - Limited data suggest that HMG-CoA reductase inhibitors (statins) reduce rates of kidney function loss. We performed this analysis to determine whether pravastatin reduced the rate of...
Effect of pravastatin in people with diabetes and chronic kidney disease (2005)
Tonelli, M, Keech, A, Shepherd, J, Sacks, F, Tonkin, A, Packard, C, ...
Although diabetes is a major cause of chronic kidney disease (CKD), limited data describe the cardiovascular benefit of hydroxymethyl glutaryl CoA reductase inhibitors (statins) in people with both...
Herrera, E., Reissland, N., Shepherd, J.
Background: Postnatal depression affects the emotional state of mothers and the quality of mother–infant interaction. Method: Touch behaviour and content of child-directed speech were analysed for...
Effect of pravastatin on cardiovascular events in people with chronic kidney disease (2004)
Tonelli, M, Isles, C, Curhan, GC, Tonkin, A, Pfeffer, MA, Shepherd, J, ...
Background - Limited data describe the cardiovascular benefit of HMG-CoA reductase inhibitors (statins) in people with moderate chronic kidney disease (CKD). The objective of this analysis was to...
Shepherd, J., Brodin, H., Cave, C., Waugh, N., Price, A., Gabbay, J.
Objective The aim of this systematic review and economic evaluation was to assess the clinical-effectiveness and cost-effectiveness of pegylated interferon-α combined with ribavirin in the treatment...
Reissland, N., Shepherd, J., Herrera, E.
Background: Research suggests that storybook reading promotes language development and that there is a relationship between maternal affective responses in relation to infant affect and language...
CMVF: A novel dimension reduction scheme for efficient indexing in a large image database (2003)
Shen, J., Ngu, A. H. H., Shepherd, J., Huynh, D. Q., Sheng, Quanzheng
Copyright 2003 ACM
CMVF: A novel dimension reduction scheme for efficient indexing in a large image database (2003)
Shen, J., Ngu, A. H. H., Shepherd, J., Huynh, D. Q., Sheng, Quanzheng
Copyright 2003 ACM
The melody of surprise : maternal surprise vocalizations during play with her infant. (2002)
Reissland, N., Shepherd, J., Cowie, L.
Two groups of mothers and their infants (24 infants, mean age=3.5 months and 24 infants, mean age=5.5 months) were video- and audio-taped in their homes while playing with a Jack-in-the-box. The mean...
The role of land carbon sinks in mitigating global climate change (2001)
Read, D., Beerling, D., Cannell, M., Cox, P., Curran, P., Grace, J., ...
As evidence for the link between atmospheric greenhouse gases and climate change has increased, international efforts have focused on ways in which anthropogenic emissions of greenhouse gases,...
Detonation Diffraction Through a Mixture Gradient (2000)
A simple one-dimensional model of a self-propagating gaseous detonation consists of a shock wave tightly coupled to a reaction zone, propagating through a combustible gas mixture as shown in Fig. 1...
Validation of Detailed Reaction Mechanisms for Detonation Simulation (2000)
This report considers the adequacy of existing detailed reaction mechanisms for use in detonation simulation with chemical systems containing hydrogen, ethylene, and propane fuels. Shock tube...
Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours (2000)
Bergman, L, Boothroyd, C, Palmer, J, Grimmond, S, Walters, M, Teh, B, ...
Endocrine tumours of the pancreas, anterior pituitary or parathyroids arise either sporadically in the general population, or as a part of inherited syndromes such as multiple endocrine neoplasia...
A Fast Indexing Method for Multidimensional Nearest Neighbor Search (1999)
This paper describes a snapshot of work in progress on the development of an efficient file-access method for similarity searching in high-dimensional vector spaces. This method has applications in,...
Serruys, P.W., Shepherd, J., Suryapranata, H., Pfister, P.J., Feyter, P.J. De, Es, G.A. Van, ...
BACKGROUND: The 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors competitively inhibit biosynthesis of mevalonate, a precursor of non-sterol compounds involved in cell...
Foley, D.P., Bonnier, H., Jackson, G., Macaya, C., Shepherd, J., Vrolix, M., ...
Prevention of restenosis after successful percutaneous transluminal coronary balloon angioplasty (PTCA) continues to present the greatest therapeutic challenge in interventional cardiology....
Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease
Kostis, J.B., Wilson, A.C., Folsom, A.R., Chambless, L., Wu, K., Benderly, M., ...
Background Many long-term studies have reported on associations of plasma fibrinogen concentration with cardiovascular disease, but few have been large enough to provide reliable estimates in...
Lowe, G., Rumley, A., Norrie, J., Ford, I., Shepherd, J., Cobbe, S., ...
The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64...
Demant, T, Bedford, D, Packard, C J, Shepherd, J
This study examined apolipoprotein (apo) B metabolism in normolipemic subjects homozygous for the apo E2 (n = 4), apo E3 (n = 5), or apo E4 (n = 5) phenotype. Radioiodinated very low density...
Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.
Demant, T, Houlston, R S, Caslake, M J, Series, J J, Shepherd, J, Packard, C J, ...
This study examines the potential influence of genetic variation on the metabolism of LDL. Restriction fragment length polymorphisms (RFLP) of the gene coding for apo B were identified using the...
An StuI RFLP at the human cholesteryl ester transfer protein (CETP) locus.
Freeman, D, Shepherd, J, Packard, C J, Humphries, S E, Gaffney, D
Nucleotide sequence of IS26, a new prokaryotic mobile genetic element.
Mollet, B, Iida, S, Shepherd, J, Arber, W
The DNA sequence of a new IS element, the IS26, is 820 bp long and carries 14 bp perfect terminal inverted repeats. Upon integration, IS26 generates an 8 bp duplication of its target sequence. A...
Shepherd, J, Packard, C J, Stewart, J M, Atmeh, R F, Clark, R S, Boag, D E, ...
This study describes the effects of bezafibrate, an analogue of clofibrate, on the plasma lipid and lipoprotein profiles of 11 hypertriglyceridemic subjects and on their metabolism of apolipoproteins...
Packard, C J, Munro, A, Lorimer, A R, Gotto, A M, Shepherd, J
The metabolic fate of very low density lipoprotein can be examined by following the transit of its apolipoprotein B moiety through the delipidation cascade, which leads to low density lipoprotein. In...
Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphisms.
Larsson, C, Shepherd, J, Nakamura, Y, Blomberg, C, Weber, G, Werelius, B, ...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited predisposition to neoplastic lesions of the parathyroids, pancreas, and the pituitary. We have previously located the...
Laker, M F, Reckless, J P, Betteridge, D J, Durrington, P N, Miller, J P, Nicholls, D P, ...
AIMS: To determine the availability of facilities for the investigation of hyperlipidaemia in the United Kingdom. METHODS: A questionnaire was sent to all health districts in the United Kingdom....
Pathophysiology of human lipoprotein receptors: clinical consequences of a cellular defect.
The function of the low density lipoprotein receptor has been reviewed at the cell level and in man. Its key role in cholesterol metabolism is unquestioned and it is central to the actions of a...
Regional and supraregional biochemistry services in Scotland: a survey of hospital laboratory users.
Murphy, M J, Dryburgh, F J, Shepherd, J
AIM--To ascertain the views of Scottish hospital laboratory users on aspects of regional and supraregional biochemical services offered by the Institute of Biochemistry at Glasgow Royal Infirmary....
Cholesterol feeding increases low density lipoprotein synthesis.
Packard, C J, McKinney, L, Carr, K, Shepherd, J
This study examines the effects of increased dietary cholesterol (6 eggs/d) on the metabolism of low density lipoproteins in a group of seven healthy volunteers. Egg supplementation raised high...
Chemical and kinetic study of the lipoproteins in abetalipoproteinaemic plasma.
Shepherd, J, Caslake, M, Farish, E, Fleck, A
Abetalipoproteinaemic plasma lipoproteins were fractionated by molecular sieve chromatography into two classes on the basis of size. Each class had the same chemical and immunochemical composition...
Bloem, J., Veninga, M., Shepherd, J.
We describe a fully automatic image analysis system capable of measuring cell numbers, volumes, lengths, and widths of bacteria in soil smears. The system also determines the number of cells in...
Prevention of cardiovascular disease in general practice: a proposed model.
Anggard, E E, Land, J M, Lenihan, C J, Packard, C J, Percy, M J, Ritchie, L D, ...
A screening model based in general practice for the detection of subjects at risk of premature cardiovascular disease is described. Opportunistic screening is performed by a trained nurse who also...
Induction of labour using prostaglandin E2 pessaries.
Shepherd, J, Pearce, J M, Sims, C D
The routine method of induction at Queen Charlotte's Maternity Hospital is now by the use of prostaglandin E2 pessaries. The first 502 consecutive patients thus induced are presented: the caesarean...
Demant, T, Bedford, D, Packard, C J, Shepherd, J
This study examined apolipoprotein (apo) B metabolism in normolipemic subjects homozygous for the apo E2 (n = 4), apo E3 (n = 5), or apo E4 (n = 5) phenotype. Radioiodinated very low density...
Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.
Demant, T, Houlston, R S, Caslake, M J, Series, J J, Shepherd, J, Packard, C J, ...
This study examines the potential influence of genetic variation on the metabolism of LDL. Restriction fragment length polymorphisms (RFLP) of the gene coding for apo B were identified using the...