J. Sicilia

Control analysis of transition times in metabolic systems.

Meléndez-Hevia, E, Torres, N V, Sicilia, J, Kacser, H

The transition time, tau, of a metabolic system is defined as the ratio of the metabolite concentrations in the system, sigma, to the steady-state flux, J. Its value reflects a temporal...

Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times.

Cascante, M, Meléndez-Hevia, E, Kholodenko, B, Sicilia, J, Kacser, H

Control analysis of transit time, defined as tau = delta/J, has previously been considered with the constraint of low enzyme concentrations compared with free pools of metabolites [Meléndez-Hevia,...

Analysis and characterization of transition states in metabolic systems. Transition times and the passivity of the output flux.

Torres, N V, Sicilia, J, Meléndez-Hevia, E

In this paper we study the transitions between steady states in metabolic systems. In order to deal with this task we divided the total metabolite concentration at steady state, sigma, into two new...

Control analysis of transition times in metabolic systems.

Meléndez-Hevia, E, Torres, N V, Sicilia, J, Kacser, H

The transition time, tau, of a metabolic system is defined as the ratio of the metabolite concentrations in the system, sigma, to the steady-state flux, J. Its value reflects a temporal...

Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times.

Cascante, M, Meléndez-Hevia, E, Kholodenko, B, Sicilia, J, Kacser, H

Control analysis of transit time, defined as tau = delta/J, has previously been considered with the constraint of low enzyme concentrations compared with free pools of metabolites [Meléndez-Hevia,...

Analysis and characterization of transition states in metabolic systems. Transition times and the passivity of the output flux.

Torres, N V, Sicilia, J, Meléndez-Hevia, E

In this paper we study the transitions between steady states in metabolic systems. In order to deal with this task we divided the total metabolite concentration at steady state, sigma, into two new...

Analysis of an inventory system with exponential partial backordering

San José, L.A., Sicilia, J., Garcia-Laguna, J.

Integer-ratio policies for distribution/inventory systems

Abdul-Jalbar, B., Gutierrez, J., Sicilia, J.

Policies for inventory/distribution systems: The effect of centralization vs. decentralization

Abdul-Jalbar, B., Gutierrez, J., Puerto, J., Sicilia, J.

The multiscenario lot size problem with concave costs

Gutierrez, J., Puerto, J., Sicilia, J.

An approach to solve the minimum expected makespan flow-shop problem subject to breakdowns

Alcaide, D., Rodriguez-Gonzalez, A., Sicilia, J.

Recent advances in theory and practice of combinatorial optimization (ECCO X)

Burkard, Rainer, Labbe, Martine, Teresa Ramos, M., Sicilia, J.

The problem of the optimal biobjective spanning tree

Ramos, R. M., Alonso, S., Sicilia, J., Gonzalez, C.

Approximate algorithms for theP‖C max problem

J. Riera, D. Alcaide, J. Sicilia

AN INVENTORY SYSTEM WITH PARTIAL BACKLOGGING MODELED ACCORDING TO A LINEAR FUNCTION

J. SICILIA, J. GARCÃA-LAGUNA

In this paper, we study an inventory system with partial backlogging, in which the backlogging rate is a continuous and nonincreasing two piece function. The total shortage cost includes three...

An efficient approach for solving the lot-sizing problem with time-varying storage capacities

Gutiérrez, J., Sedeí±o-Noda, A., Colebrook, M., Sicilia, J.

We address the dynamic lot size problem assuming time-varying storage capacities. The planning horizon is divided into T periods and stockouts are not allowed. Moreover, for each period, we consider...