Bourquin, J P, Stagljar, I, Meier, P, Moosmann, P, Silke, J, Baechi, T, ...
The largest subunit of RNA polymerase II shows a striking difference in the degree of phosphorylation, depending on its functional state: initiating and elongating polymerases are unphosphorylated...
The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+.
Matsuo, K, Silke, J, Gramatikoff, K, Schaffner, W
A prokaryotic CpG-specific methylase from Spiroplasma, SssI methylase, is now widely used to study the effect of CpG methylation in mammalian cells, and can processively modify cytosines in CpG...
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA.
Matsuo, K, Silke, J, Georgiev, O, Marti, P, Giovannini, N, Rungger, D
In vertebrates, transcriptionally active promoters are undermethylated. Since the transcription factor Sp1, and more recently NF-kappaB, have been implicated in the demethylation process, we examined...
Ekert, P G, Silke, J, Vaux, D L
To study the role of various caspases during apoptosis, we have designed a series of caspase inhibitors based on the cowpox virus cytokine response modifier A (crmA) protein. Wild-type crmA inhibits...
Bourquin, J P, Stagljar, I, Meier, P, Moosmann, P, Silke, J, Baechi, T, ...
The largest subunit of RNA polymerase II shows a striking difference in the degree of phosphorylation, depending on its functional state: initiating and elongating polymerases are unphosphorylated...
The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+.
Matsuo, K, Silke, J, Gramatikoff, K, Schaffner, W
A prokaryotic CpG-specific methylase from Spiroplasma, SssI methylase, is now widely used to study the effect of CpG methylation in mammalian cells, and can processively modify cytosines in CpG...
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA.
Matsuo, K, Silke, J, Georgiev, O, Marti, P, Giovannini, N, Rungger, D
In vertebrates, transcriptionally active promoters are undermethylated. Since the transcription factor Sp1, and more recently NF-kappaB, have been implicated in the demethylation process, we examined...
Ekert, P G, Silke, J, Vaux, D L
To study the role of various caspases during apoptosis, we have designed a series of caspase inhibitors based on the cowpox virus cytokine response modifier A (crmA) protein. Wild-type crmA inhibits...
Dunning, C J R, McKenzie, M, Sugiana, C, Lazarou, M, Silke, J, Connelly, A, ...
In humans, complex I of the respiratory chain is composed of seven mitochondrial DNA (mtDNA)-encoded and 38 nuclear-encoded subunits that assemble together in a process that is poorly defined. To...