Evolution of competence and DNA uptake specificity in the Pasteurellaceae (2006)
Redfield, Rosemary J, Findlay, Wendy A, Bossé, Janine, Kroll, J Simon, Cameron, Andrew DS, Nash, John HE
Abstract Background Many bacteria can take up DNA, but the evolutionary history and function of natural competence and transformation remain obscure. The sporadic distribution of competence suggests...
Haemophilus Influenzae Microarrays: Virulence and Vaccines (2006)
Tahir R. Ali, J. Simon Kroll, Paul R. Langford
In 1995 the genome sequence of the Haemophilus influenzae KW20 (Rd) strain was published, the first available for a free-living organism. The genome has been invaluable in global strategies to...
Kroll, J. Simon, Wilks, Kathryn E., Farrant, Jayne L., Langford, Paul R.
Members of the bacterial families Haemophilus and Neisseria, important human pathogens that commonly colonize the nasopharynx, are naturally competent for DNA uptake from their environment. In each...
Yu, Jun, Edwards-Jones, Bryn, Neyrolles, Olivier, Kroll, J. Simon
DsbA, a disulfide bond catalyst, is necessary for realization of the pathogenic potential of Shigella flexneri. Sh42, a mutant strain differing from wild-type M90TS solely because it expresses...
Sheehan, Brian J., Langford, Paul R., Rycroft, Andrew N., Kroll, J. Simon
Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, contains a periplasmic Cu- and Zn-cofactored superoxide dismutase ([Cu,Zn]-SOD, or SodC) which has the potential,...
Periplasmic Superoxide Dismutase in Meningococcal Pathogenicity
Wilks, Kathryn E., Dunn, Kate L. R., Farrant, Jayne L., Reddin, Karen M., Gorringe, Andrew R., Langford, Paul R., ...
Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a...
Humoral Immune Responses to Neisseria meningitidis in Children
Pollard, Andrew J., Galassini, Rachel, Booy, Robert, Langford, Paul, Nadel, Simon, ...
An understanding of the nature of immunity to serogroup B meningococci in childhood is necessary in order to establish the reasons for poor responses to candidate vaccines in infancy. We sought to...
Cellular Immune Responses to Neisseria meningitidis in Children
Pollard, Andrew J., Galassini, Rachel, Hibberd, Martin, Booy, Robert, Langford, Paul, ...
There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure...
Langford, Paul R., Sheehan, Brian J., Shaikh, Taheed, Kroll, J. Simon
The presence of active copper- and zinc-containing superoxide dismutase in isolates of the cryptic genospecies of Haemophilus, responsible for urogenital, neonatal, and mother-infant infections, can...
Dunn, Kate L. R., Farrant, Jayne L., Langford, Paul R., Kroll, J. Simon
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages,...
Meats, Emma, Feil, Edward J., Stringer, Suzanna, Cody, Alison J., Goldstein, Richard, Kroll, J. Simon, ...
A multilocus sequence typing (MLST) scheme has been developed for the unambiguous characterization of encapsulated and noncapsulated Haemophilus influenzae isolates. The sequences of internal...
Sheehan, Brian J., Bossé, Janine T., Beddek, Amanda J., Rycroft, Andrew N., Kroll, J. Simon, Langford, Paul R.
Actinobacillus pleuropneumoniae is a strict respiratory tract pathogen of swine and is the causative agent of porcine pleuropneumonia. We have used signature-tagged mutagenesis (STM) to identify...
Two TonB Systems in Actinobacillus pleuropneumoniae: Their Roles in Iron Acquisition and Virulence
Beddek, Amanda J., Sheehan, Brian J., Bossé, Janine T., Rycroft, Andrew N., Kroll, J. Simon, Langford, Paul R.
Iron acquisition in vivo by Actinobacillus pleuropneumoniae depends upon a functional TonB system. Tonpitak et al. (W. Tonpitak, S. Thiede, W. Oswald, N. Baltes, and G.-F. Gerlach, Infect. Immun....
O'Dwyer, Clíona A., Reddin, Karen, Martin, Denis, Taylor, Stephen C., Gorringe, Andrew R., Hudson, Michael J., ...
Commensal neisseriae share with Neisseria meningitidis (meningococcus) a tendency towards overproduction of the bacterial outer envelope, leading to the formation and release during growth of outer...
Southern, Jo, Deane, Sarah, Ashton, Lindsey, Borrow, Ray, Goldblatt, David, Andrews, Nick, ...
Extensive use of meningococcal AC polysaccharide (MACP) vaccines has raised concerns about induction of immunologic hyporesponsiveness to C polysaccharide. We investigated the immunogenicity and...
Evolution of competence and DNA uptake specificity in the Pasteurellaceae
Redfield, Rosemary J, Findlay, Wendy A, Bossé, Janine, Kroll, J Simon, Cameron, Andrew DS, Nash, John HE
Kroll, J. Simon, Wilks, Kathryn E., Farrant, Jayne L., Langford, Paul R.
Members of the bacterial families Haemophilus and Neisseria, important human pathogens that commonly colonize the nasopharynx, are naturally competent for DNA uptake from their environment. In each...
Yu, Jun, Edwards-Jones, Bryn, Neyrolles, Olivier, Kroll, J. Simon
DsbA, a disulfide bond catalyst, is necessary for realization of the pathogenic potential of Shigella flexneri. Sh42, a mutant strain differing from wild-type M90TS solely because it expresses...
Sheehan, Brian J., Langford, Paul R., Rycroft, Andrew N., Kroll, J. Simon
Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, contains a periplasmic Cu- and Zn-cofactored superoxide dismutase ([Cu,Zn]-SOD, or SodC) which has the potential,...
Periplasmic Superoxide Dismutase in Meningococcal Pathogenicity
Wilks, Kathryn E., Dunn, Kate L. R., Farrant, Jayne L., Reddin, Karen M., Gorringe, Andrew R., Langford, Paul R., ...
Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a...
Humoral Immune Responses to Neisseria meningitidis in Children
Pollard, Andrew J., Galassini, Rachel, Booy, Robert, Langford, Paul, Nadel, Simon, ...
An understanding of the nature of immunity to serogroup B meningococci in childhood is necessary in order to establish the reasons for poor responses to candidate vaccines in infancy. We sought to...
Cellular Immune Responses to Neisseria meningitidis in Children
Pollard, Andrew J., Galassini, Rachel, Hibberd, Martin, Booy, Robert, Langford, Paul, ...
There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure...
Langford, Paul R., Sheehan, Brian J., Shaikh, Taheed, Kroll, J. Simon
The presence of active copper- and zinc-containing superoxide dismutase in isolates of the cryptic genospecies of Haemophilus, responsible for urogenital, neonatal, and mother-infant infections, can...
Dunn, Kate L. R., Farrant, Jayne L., Langford, Paul R., Kroll, J. Simon
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages,...
Meats, Emma, Feil, Edward J., Stringer, Suzanna, Cody, Alison J., Goldstein, Richard, Kroll, J. Simon, ...
A multilocus sequence typing (MLST) scheme has been developed for the unambiguous characterization of encapsulated and noncapsulated Haemophilus influenzae isolates. The sequences of internal...
Sheehan, Brian J., Bossé, Janine T., Beddek, Amanda J., Rycroft, Andrew N., Kroll, J. Simon, Langford, Paul R.
Actinobacillus pleuropneumoniae is a strict respiratory tract pathogen of swine and is the causative agent of porcine pleuropneumonia. We have used signature-tagged mutagenesis (STM) to identify...
Two TonB Systems in Actinobacillus pleuropneumoniae: Their Roles in Iron Acquisition and Virulence
Beddek, Amanda J., Sheehan, Brian J., Bossé, Janine T., Rycroft, Andrew N., Kroll, J. Simon, Langford, Paul R.
Iron acquisition in vivo by Actinobacillus pleuropneumoniae depends upon a functional TonB system. Tonpitak et al. (W. Tonpitak, S. Thiede, W. Oswald, N. Baltes, and G.-F. Gerlach, Infect. Immun....
O'Dwyer, Clíona A., Reddin, Karen, Martin, Denis, Taylor, Stephen C., Gorringe, Andrew R., Hudson, Michael J., ...
Commensal neisseriae share with Neisseria meningitidis (meningococcus) a tendency towards overproduction of the bacterial outer envelope, leading to the formation and release during growth of outer...
Southern, Jo, Deane, Sarah, Ashton, Lindsey, Borrow, Ray, Goldblatt, David, Andrews, Nick, ...
Extensive use of meningococcal AC polysaccharide (MACP) vaccines has raised concerns about induction of immunologic hyporesponsiveness to C polysaccharide. We investigated the immunogenicity and...
Evolution of competence and DNA uptake specificity in the Pasteurellaceae
Redfield, Rosemary J, Findlay, Wendy A, Bossé, Janine, Kroll, J Simon, Cameron, Andrew DS, Nash, John HE
Fung, W. W. Mary, O'Dwyer, Clíona A., Sinha, Sunita, Brauer, Aimee L., Murphy, Timothy F., Kroll, J. Simon, ...
Respiratory isolates of Haemophilus haemolyticus are regularly misclassified as nontypeable (NT) Haemophilus influenzae due to an aberrant hemolytic reaction on blood agar, with implications for...
Haemophilus Influenzae Microarrays: Virulence and Vaccines
Ali, Tahir R., Kroll, J. Simon, Langford, Paul R.
In 1995 the genome sequence of the Haemophilus influenzae KW20 (Rd) strain was published, the first available for a free-living organism. The genome has been invaluable in global strategies to...