Zhang, W, Doherty, M, Leeb, BF, Alekseeva, L, Arden, NK, Bijlsma, JW, ...
Objectives: To develop evidence-based recommendations for the diagnosis of hand osteoarthritis (OA). Methods: The multidisciplinary guideline development group, representing 15 European countries,...
Zhang, W., Doherty, M., Leeb, B.F., Alekseeva, L., Arden, N.K., Bijlsma, J.W., ...
OBJECTIVES: To develop evidence based recommendations for the management of hand osteoarthritis (OA). METHODS: The multidisciplinary guideline development group comprised 16 rheumatologists, one...
ZHANG, W, DOHERTY, M, LEEB, BF, ALEKSEEVA, L, ARDEN, NK, BIJLSMA, JW, ...
Abarca, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A O, ...
The "Euro-Lupus Cohort" is composed by 1000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European...
Combe, B., Codreanu, C., Fiocco, U., Gaubitz, M., Kvien, T., ...
To compare the efficacy and safety of etanercept and sulfasalazine, alone and in combination, in patients with active rheumatoid arthritis despite sulfasalazine treatment.Methods: A double-blind,...
Combe, B., Codreanu, C., Fiocco, U., Gaubitz, M., Kvien, T., ...
To compare the efficacy and safety of etanercept and sulfasalazine, alone and in combination, in patients with active rheumatoid arthritis despite sulfasalazine treatment.Methods: A double-blind,...
Combe, B., Codreanu, C., Fiocco, U., Gaubitz, M., GEUSENS, Piet, Kvien, T., ...
To compare the efficacy and safety of etanercept and sulfasalazine, alone and in combination, in patients with active rheumatoid arthritis despite sulfasalazine treatment.Methods: A double-blind,...
Direct analysis of bone turnover in experimental arthritis (2005)
Polzer, K, Tuerk, B, Redlich, K, Hayer, S, Smolen, J, Schett, G
No abstract available.
Bobacz, K, Erlacher, L, Smolen, J, Graninger, W
No abstract available.
Autoantibodies in very early rheumatoid arthritis: diagnostic tools or pathogenic players? (2003)
Steiner, G, Nell, V, Eberl, G, Hayer, S, Machold, K, Hoefler, E, ...
No abstract available.
Redlich, K, Goertz, B, Doerr, N, Kollias, G, Steiner, G, Smolen, J, ...
No abstract available.
Osteoprotegerin protects from generalized bone loss in TNF-transgenic mice (2003)
Hayer, S, Redlich, K, Zwerina, J, Bolon, B, Dunstan, C, Görtz, B, ...
No abstract available.
Bobacz, K, Soleiman, A, Erlacher, L, Smolen, J, Graninger, WB
No abstract available.
Clinical and immunological effects of anti-TNF therapy in systemic lupus erythematosus (SLE) (2003)
Aringer, M, Steiner, G, Graninger, WB, Höfler, E, Hiesberger, H, Steiner, C-W, ...
No abstract available.
Schett, G, Monneaux, F, Hoefler, E, Fritsch, R, Tohidast-Akrad, M, Smolen, J, ...
No abstract available.
Nell, V, Machold, K, Hueber, W, Eberl, G, Hiesberger, H, Hoefler, E, ...
No abstract available.
Zwerina, J, Hayer, S, Redlich, K, Feige, U, Dunstan, C, Bergmeister, H, ...
No abstract available.
Codreanu, C, Combe, B, Fiocco, U, Gaubitz, M, Kvien, T, Pavelka, K, ...
Centrul Metodol Reumatol, Bucharest, Romania. Hop Lapeyronie, Serv ImmunoRhumatol, Montpellier, France. Polyclin Univ, Cattedra Reumatol, Azienda Clin Osped Padova, Padua, Italy. Polyclin Univ, Div...
Codreanu, C, Combe, B, Fiocco, U, Gaubitz, M, Kvien, T, Pavelka, K, ...
Centrul Metodol Reumatol, Bucharest, Romania. Hop Lapeyronie, Serv ImmunoRhumatol, Montpellier, France. Polyclin Univ, Cattedra Reumatol, Azienda Clin Osped Padova, Padua, Italy. Polyclin Univ, Div...
Lessons from the "Euro-Lupus Cohort" (2002)
Abarca, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A O, ...
The "Euro-Lupus Cohort" is composed by 1,000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European...
Hayer, S, Tohidast-Akrad, M, Schett, G, El Gabalawy, H, Smolen, J, Steiner, G
No abstract available.
Jimenez-Boj, E, Schett, G, Kedersha, N, Zimmermann, C, Hoefler, E, Smolen, J, ...
No abstract available.
Hayer, S, Tohidast-Akrad, M, Schett, G, Skriner, K, Plows, D, Haralambos, S, ...
No abstract available.
Fritsch, R, Eselböck, D, Jahn-Schmid, B, Scheinecker, C, Bohle, B, Skriner, K, ...
No abstract available.
Characterization of RA33 (hnRNP-A2/B1)-autoreactive T cells in SLE-patients (2001)
Fritsch, R, Eselböck, D, Jahn-Schmid, B, Neumueller, J, Bohle, B, Skriner, K, ...
No abstract available.
Schett, G, Hayer, S, Xu, Q, Tohidast-Akrad, M, Kollias, G, Steiner, G, ...
No abstract available.
Schett, G., Firbas, U., Füreder, W., Hiesberger, H., Winkler, S., Wachauer, D., ...
Objective. This study was performed to assess erythropoietin levels and anti‐erythropoietin antibodies in patients with systemic lupus erythematosus (SLE). Methods. The sera of...
Predictors of Early Bone Erosion in Patients With Synovitis of Recent Onset (1999)
Lee, J, Goldbach-Mansky, R, Hitchon, C, Danning, C, Aringer, M, Hoxworth, J, ...
No abstract available.
Brooks, P., Emery, P., Evans, J. F., Fenner, H., Hawkey, C. J., Patrono, C., ...
The International Consensus Meeting on the Mode of Action of COX-2 Inhibition (ICMMAC) brought together 17 international experts in arthritis, gastroenterology and pharmacology on 5–6 December...
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients (1998)
Wiesinger, GF, Quittan, M, Graninger, M, Seeber, A, Ebenbichler, G, Sturm, B, ...
WYLIE, G., APPELBOOM, T., BOLTEN, W., BREEDVELD, F. C., FEELY, J., LEEMING, M. R. G., ...
Tenidap is a novel anti-rheumatic drug that combines cytokine modulation with cyclo-oxygenase inhibition. This 24-week, multicentre, double-blind, randomized study compared the clinical efficacy,...
BENCIVELLI, W, VITALI, C, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
VITALI, C, BENCIVELLI, W, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
VITALI, C, BENCIVELLI, W, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
Schett, G, Redlich, K, Xu, Q, Bizan, P, Gröger, M, Tohidast-Akrad, M, ...
Heat shock proteins (hsp) have been repeatedly implicated to participate in the pathogenesis of rheumatoid arthritis (RA). Herein, we investigated the regulation of synovial hsp70 expression by...
Schett, G, Redlich, K, Xu, Q, Bizan, P, Gröger, M, Tohidast-Akrad, M, ...
Heat shock proteins (hsp) have been repeatedly implicated to participate in the pathogenesis of rheumatoid arthritis (RA). Herein, we investigated the regulation of synovial hsp70 expression by...
Steffen, C, Kovac, W, Endler, T A, Menzel, J, Smolen, J
Three groups of rabbits were injected intra-articularly into the knee joints with preformed complexes of hydroxamated collagen and antiserum to denatured collagen respectively, with hydroxamated...
T cell derived cytokines in psoriatic arthritis synovial fluids
Partsch, G., Wagner, E., Leeb, B., Broll, H., Dunky, A., Smolen, J.
OBJECTIVE—The aim of this study was to investigate the concentrations of T cell derived cytokines in the synovial fluids (SFs) of patients with psoriatic arthritis (PsA) in comparison with...
Koller, M, Aringer, M, Kiener, H, Erlacher, L, Machold, K, Eberl, G, ...
OBJECTIVE—To determine the presence of adhesion molecules on monocytes/macrophages (Mϕ) from peripheral blood (PB) and synovial fluid (SF) in patients with osteoarthritis (OA) and inflammatory...
Concurrence of sarcoidosis and aortitis: case report and review of the literature
Weiler, V, Redtenbacher, S, Bancher, C, Fischer, M, Smolen, J
Takayasu arteritis (TA) is a rare manifestation of systemic large vessel vasculitis which affects predominantly the aorta and its main branches, but often remains unrecognised owing to delayed...
Redlich, K., Ziegler, S., Kiener, H., Spitzauer, S., Stohlawetz, P., Bernecker, P., ...
OBJECTIVE—To evaluate bone mineral density and biochemical parameters of bone metabolism in ambulatory premenopausal female patients with systemic lupus erythematosus (SLE). METHODS—30 women...
Scott, D, Smolen, J, Kalden, J, Larsen, A, Kvien, T, ...
OBJECTIVE—Recent studies have demonstrated the short term efficacy of leflunomide. This study evaluates the efficacy and safety of leflunomide and sulfasalazine in rheumatoid arthritis over a two...
Emery, P, Breedveld, F, Dougados, M, Kalden, J, Schiff, M, Smolen, J
Objective: To develop a referral recommendation that may serve as a clinical guide for primary care doctors, enabling them to identify patients with suspected RA during the early inflammatory stages.
Tzioufas, A, Wassmuth, R, Dafni, U, Guialis, A, Haga, H, Isenberg, D, ...
Objectives: To investigate the clinical and immunogenetic aspects of antibody formation against Ro/SSA and La/SSB as well as their linear B cell epitopes in patients with primary Sjögren's syndrome...
Aletaha, D, Eberl, G, Nell, V, Machold, K, Smolen, J
Background: Early diagnosis and treatment with disease modifying antirheumatic drugs (DMARDs) have been advocated for patients with rheumatoid arthritis (RA). This survey focuses on the individual...
Aletaha, D, Stamm, T, Kapral, T, Eberl, G, Grisar, J, Machold, K, ...
Objective: To determine the survival and clinical effectiveness of leflunomide (LEF) compared with methotrexate (MTX) and sulfasalazine (SSZ) for RA in an observational study.
Toxicity profiles of traditional disease modifying antirheumatic drugs for rheumatoid arthritis
Aletaha, D, Kapral, T, Smolen, J
Objective: To explore the toxicity profiles of DMARDs in daily life.
Wick, M, Peloschek, P, Bogl, K, Graninger, W, Smolen, J, Kainberger, F
Objective: To develop computer assisted quantification software that is particularly applicable to joint scoring in rheumatic disorders.
Infliximab in active early rheumatoid arthritis
Breedveld, F, Emery, P, Keystone, E, Patel, K, Furst, D, Kalden, J, ...
Objective: To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early rheumatoid arthritis (RA).
Access to disease modifying treatments for rheumatoid arthritis patients
FURST, D, BREEDVELD, F, BURMESTER, G, CROFFORD, L, EMERY, P, FELDMAN, M, ...
FURST, D, KEYSTONE, E, BREEDVELD, F, KALDEN, J, SMOLEN, J, ANTONI, C, ...
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Antoni, C, Bijlsma, J, ...
Increased transendothelial migration of scleroderma lymphocytes
Stummvoll, G, Aringer, M, Grisar, J, Steiner, C, Smolen, J, Knobler, R, ...
Background: CD4+ T lymphocytes play an important part in the pathogenesis of scleroderma (systemic sclerosis, SSc) and predominate in perivascular SSc skin lesions. Both soluble and membrane bound...
Yee, C, Gordon, C, Dostal, C, Petera, P, Dadoniene, J, Griffiths, B, ...
Objective: To compare the efficacy and side effects of intermittent pulse cyclophosphamide plus methylprednisolone with continuous oral cyclophosphamide plus prednisolone, followed by azathioprine,...
Kalden, J, Scott, D, Smolen, J, Strand, V
Methods: Patients treated with leflunomide for >2 years in one of three phase III trials and subsequent extensions, for whom paired, evaluable radiographs at baseline and study end point were...
Maurer, D, Felzmann, T, Holter, W, Petera, P, Smolen, J, Knapp, W
We have investigated whether T cell activation in rheumatoid arthritis (RA) preferentially engages distinct T cell subpopulations in the peripheral blood (PB) and in the synovial fluid. We found that...
IgA autoreactivity: a feature common to inflammatory bowel and connective tissue diseases
KAZEMI-SHIRAZI, L, GASCHE, C H, NATTER, S, GANGL, A, SMOLEN, J, SPITZAUER, S, ...
The immunopathogenic mechanisms in inflammatory bowel disease (IBD) are not yet fully established. The aim of this study was to determine the profile and magnitude of IgA and IgG autoantibodies in...
Attitudes to early rheumatoid arthritis: changing patterns. Results of a survey
Aletaha, D, Eberl, G, Nell, V, Machold, K, Smolen, J
Objective: To determine if rheumatologists have changed their views on diagnosis and treatment of early rheumatoid arthritis (RA).
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Burmester, G, Bijlsma, J, ...
Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells
Grisar, J, Aringer, M, Koller, M, Stummvoll, G, Eselbock, D, Zwolfer, B, ...
Objectives: To test whether the active metabolite of leflunomide (LEF-M), in addition to blocking the proliferation of activated lymphocytes by inhibiting dihydro-orotate dehydrogenase (DHODH),...
Bobacz, K, Erlacher, L, Smolen, J, Soleiman, A, Graninger, W
Objective: To correlate the number of chondrocytes in healthy and osteoarthritic human articular cartilage with age, and to evaluate the influence of donor age on total proteoglycan synthesis.
Pituitary function in patients with newly diagnosed untreated systemic lupus erythematosus
Koller, M, Templ, E, Riedl, M, Clodi, M, Wagner, O, Smolen, J, ...
Methods: 11 patients with SLE and 9 healthy controls were tested for their total anterior pituitary gland reserve by simultaneous injection of corticotropin-, growth hormone- (GH), thyrotropin-, and...
Wolf, J, Stranzl, T, Filipits, M, Pohl, G, Pirker, R, Leeb, B, ...
Background: Methotrexate is transported into the cell by the reduced folate carrier (RFC) and out of the cell by members of the multidrug resistance protein family (MRP). Transport proteins may...
Stummvoll, G, Aringer, M, Smolen, J, Schmaldienst, S, Jimenez-Boj, E, Horl, W, ...
Objective: To analyse the effects of rigorous immunoglobulin removal by immunoadsorption (IAS) on proteinuria (primary outcome variable), disease activity (SIS, SLEDAI, ECLAM), and autoantibodies to...
The burden of rheumatoid arthritis and access to treatment: a medical overview
Rheumatoid arthritis, A, A1, A10, A31, I11,
The burden of rheumatoid arthritis and access to treatment: uptake of new therapies
B. Jönsson, G. Kobelt, J. Smolen
Rheumatoid arthritis, Treatment access, Affordability, I11,
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Burmester, G, Bijlsma, J, ...
Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis
Nell, V, Machold, K, Stamm, T, Eberl, G, Heinzl, H, Uffmann, M, ...
Background: Early treatment prevents progression of joint damage in rheumatoid arthritis (RA), but diagnosis in early disease is impeded by lack of appropriate diagnostic criteria.
Wells, G, Becker, J-C, Teng, J, Dougados, M, Schiff, M, Smolen, J, ...