A second generation human haplotype map of over 3.1 million SNPs (2007)
Frazer, Kelly A., Ballinger, Dennis G., Cox, David R., Hinds, David A., Stuve, Laura L., Gibbs, Richard A., ...
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...
Liver-targeting liposomal doxorubicin preparation for treatment of liver cancer (2006)
Most of the cytotoxic drugs used in cancer chemotherapy have narrow chemotherapeutic utility and effectiveness and serious side effects at high dosages. As a result, drug delivery systems have been...
Compositions and methods for the targeted delivery of agents to treat liver cancer (2006)
Wong, J. Tze-Fei, Tsang, Shui Ying Sue
Most of the cytotoxic drugs used in cancer chemotherapy have narrow chemotherapeutic utility and effectiveness and serious side effects at high dosages. As a result, drug delivery systems have been...
Pulmonary drug delivery system (1995)
Wong, J. Tze-Fei, Tam, Michael S. C.
The present invention provides a method of improving the efficiency of absorption into the bloodstream of drugs delivered through the pulmonary route. The drug is mixed with surfactant, preferably a...
Gu, Xiang-Rong, Nicoghosian, K., Cedergren, R.J., Wong, J.Tze-Fei
The sequence of three tRNAs from Halobacterium cutirubrum have been determined. The sequences of tRNAGACVal and tRNAGACVal differ by only one nucleotide which is in the 5' terminal anticodon...
Nature of Ribosome-Bound β-Galactosidase
Bronskill, Patricia M., Wong, J. Tze-Fei
Properties of the ribosome-bound β-galactosidase were examined in Escherichia coli cells after prolonged induction. This fraction of enzyme was not chased from ribosomes by removal of inducer, or by...
Inhibitor-Induced Shift-Downs in Escherichia coli
Nazar, Ross N., Wong, J. Tze-Fei
A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic...
The evolution of a universal genetic code
Some of the basic problems presented by the rapid evolution of a universal genetic code can be resolved by a mechanism of co-evolution of the code and the amino acids it serves.
A Co-Evolution Theory of the Genetic Code
The theory is proposed that the structure of the genetic code was determined by the sequence of evolutionary emergence of new amino acids within the primordial biochemical system.
Nature of Ribosome-Bound β-Galactosidase
Bronskill, Patricia M., Wong, J. Tze-Fei
Properties of the ribosome-bound β-galactosidase were examined in Escherichia coli cells after prolonged induction. This fraction of enzyme was not chased from ribosomes by removal of inducer, or by...
Inhibitor-Induced Shift-Downs in Escherichia coli
Nazar, Ross N., Wong, J. Tze-Fei
A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic...
The evolution of a universal genetic code
Some of the basic problems presented by the rapid evolution of a universal genetic code can be resolved by a mechanism of co-evolution of the code and the amino acids it serves.
A Co-Evolution Theory of the Genetic Code
The theory is proposed that the structure of the genetic code was determined by the sequence of evolutionary emergence of new amino acids within the primordial biochemical system.