J. V. Platko

A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.

Platko, J V, Leonard, D A, Adra, C N, Shaw, R J, Cerione, R A, Lim, B

The GDP dissociation inhibitors (GDIs) represent an important class of regulatory proteins for the Rho- and Rab-subtype GTP-binding proteins. As a first step toward identifying the key functional...

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

Guy, P M, Platko, J V, Cantley, L C, Cerione, R A, Carraway, K L

Protein kinases share a number of highly conserved or invariant amino acid residues in their catalytic domains, suggesting that these residues are necessary for kinase activity. In p180erbB3, a...

Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli.

Braaten, B A, Platko, J V, Van Der Woude, M W, Simons, B H, De Graaf, F K, Calvo, J M, ...

The methylation blocking factor gene (mbf) in Escherichia coli is required for specific methylation inhibition of two DNA GATC sites upstream of the papBA pilin promoter and transcriptional...

The amino acid sequence of Lrp is highly conserved in four enteric microorganisms.

Friedberg, D, Platko, J V, Tyler, B, Calvo, J M

Lrp (leucine-responsive regulatory protein) is a global regulator of metabolism in Escherichia coli (J. M. Calvo and R. G. Matthews, Microbiol. Rev. 58:466-490, 1994). The lrp genes from three other...

Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine.

Platko, J V, Calvo, J M

Lrp is a regulatory protein in Escherichia coli that increases expression of some operons and decreases expression of others. Mutations in Lrp were isolated on the basis of their effects on ilvIH,...

Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli.

Haney, S A, Platko, J V, Oxender, D L, Calvo, J M

We investigated the relationship between two regulatory genes, livR and lrp, that map near min 20 on the Escherichia coli chromosome. livR was identified earlier as a regulatory gene affecting...

The ilvIH operon of Escherichia coli is positively regulated.

Platko, J V, Willins, D A, Calvo, J M

The ilvIH operon of Escherichia coli (located near min 2) encodes acetohydroxyacid synthase III, an isozyme involved in branched-chain amino acid biosynthesis. A strain with lacZ fused to the ilvIH...

A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.

Platko, J V, Leonard, D A, Adra, C N, Shaw, R J, Cerione, R A, Lim, B

The GDP dissociation inhibitors (GDIs) represent an important class of regulatory proteins for the Rho- and Rab-subtype GTP-binding proteins. As a first step toward identifying the key functional...

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

Guy, P M, Platko, J V, Cantley, L C, Cerione, R A, Carraway, K L

Protein kinases share a number of highly conserved or invariant amino acid residues in their catalytic domains, suggesting that these residues are necessary for kinase activity. In p180erbB3, a...

Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli.

Braaten, B A, Platko, J V, Van Der Woude, M W, Simons, B H, De Graaf, F K, Calvo, J M, ...

The methylation blocking factor gene (mbf) in Escherichia coli is required for specific methylation inhibition of two DNA GATC sites upstream of the papBA pilin promoter and transcriptional...

The amino acid sequence of Lrp is highly conserved in four enteric microorganisms.

Friedberg, D, Platko, J V, Tyler, B, Calvo, J M

Lrp (leucine-responsive regulatory protein) is a global regulator of metabolism in Escherichia coli (J. M. Calvo and R. G. Matthews, Microbiol. Rev. 58:466-490, 1994). The lrp genes from three other...

Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine.

Platko, J V, Calvo, J M

Lrp is a regulatory protein in Escherichia coli that increases expression of some operons and decreases expression of others. Mutations in Lrp were isolated on the basis of their effects on ilvIH,...

Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli.

Haney, S A, Platko, J V, Oxender, D L, Calvo, J M

We investigated the relationship between two regulatory genes, livR and lrp, that map near min 20 on the Escherichia coli chromosome. livR was identified earlier as a regulatory gene affecting...

The ilvIH operon of Escherichia coli is positively regulated.

Platko, J V, Willins, D A, Calvo, J M

The ilvIH operon of Escherichia coli (located near min 2) encodes acetohydroxyacid synthase III, an isozyme involved in branched-chain amino acid biosynthesis. A strain with lacZ fused to the ilvIH...