Bigaignon, G, Markine-Goriaynoff, D, Nguyen, T N, Warnier, G, ...
The aim of this study was the analysis of the cytokine response in BALB/c mice infected with the highly virulent RH or the weakly virulent Beverley strains of Toxoplasma gondii. Analysis of cytokine...
DE SMEDT, M, Verhasselt, Bruno, Kerre, Tessa, Vanhecke, Dominique, NAESSENS, E, Leclercq, Georges, ...
Uyttenhove, C, Houssiau, F, Put, W, Van Snick, J
Two mouse helper T cell clones that proliferate in response to murine interleukin (IL)-9 could also be grown in conditioned medium of stimulated human connective tissue cells. The activity was not...
Van Beeumen, J, Decock, B, Van Snick, J
Supernatants of mitogen-stimulated human leukocytes contain two biologically related cytokines, IL-1 and hybridoma growth factor (HGF). IL-1 beta is a potent inducer of HGF in fibroblasts but has...
Vink, A, Simpson, R J, Van Snick, J
We have recently purified and partially sequenced a new T cell-derived lymphokine with growth factor activity for B cell hybridomas and plasmacytomas, which we named interleukin HP1 (HP1). Here we...
Cayphas, S, Van Snick, J, Conings, R, Put, W, Lenaerts, J P, ...
Human fibroblast cultures, when stimulated with interleukin-1 (IL-1) produce a growth factor for B-cell hybridoma and plasmocytoma cell lines. The availability of both a fast-growing and...
This study confirms our earlier finding that human interleukin (IL)-1 beta exerts an antiviral effect on diploid fibroblasts and on MG-63 osteosarcoma cells. It also extends the observation in that a...
Simpson, R J, Rubira, M R, Cayphas, S, Vink, A, ...
A factor that promotes the growth of certain B cell hybridomas and of plasmacytomas is shown to be produced by normal human fibroblasts and by a line of human osteosarcoma cells (MG-63) after...
Cultures of normal diploid fibroblasts and of a human osteosarcoma cell line (MG-63) are shown to be able to produce a factor which promotes the growth of B cell hybridomas (hybridoma growth factor,...
Heinen, Ernst, Coulie, P, Van Snick, J, Braun, M, Cormann, N, Moeremans, M, ...
Using monoclonal anti-trinitrophenyl (TNP) antibodies complexed to TNP-myoglobin-coated gold particles, we analysed at the ultrastructural level the retention by follicular dendritic cells (FDC) of...
Transfer of immune complexes from lymphocytes to follicular dendritic cells. (1986)
Heinen, Ernst, Braun, M, Coulie, P G, Van Snick, J, Moeremans, M, Cormann, N, ...
Antigens in the form of immune complexes are retained on the membranes of follicular dendritic cells (FDC) for long periods of time. To examine how immune complexes reach germinal centers, where FDC...
Expression cloning of the murine and human interleukin 9 receptor cDNAs.
Renauld, J C, Druez, C, Kermouni, A, Houssiau, F, Uyttenhove, C, Van Roost, E, ...
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression...
Interleukin-9 Enhances Resistance to the Intestinal Nematode Trichuris muris
Faulkner, Helen, Van Snick, J., Grencis, R. K.
Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In...
Khan, W. I., Richard, M., Akiho, H., Blennerhasset, P. A., Humphreys, N. E., Grencis, R. K., ...
Immune responses associated with intestinal nematode infections are characterized by the activation of T-helper 2 (Th2) cells. Previous studies demonstrated that during Trichinella spiralis...
Demoulin, J B, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, ...
Interleukin-9 (IL-9), a T-cell-derived cytokine, interacts with a specific receptor associated with the IL-2 receptor gamma chain. In this report, we analyze the functional domains of the human IL-9...
Uyttenhove, C, Simpson, R J, Van Snick, J
Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the...
Van Snick, J, Cayphas, S, Vink, A, Uyttenhove, C, Coulie, P G, Rubira, M R, ...
A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas. Hybrids that failed to survive in the absence of this molecule represented a major...
Poupart, P, Vandenabeele, P, Cayphas, S, Van Snick, J, Haegeman, G, Kruys, V, ...
The human "26-kd protein' is a secreted glycoprotein expressed, for example, in (blood) leukocytes, in epithelial cells treated with various inducers, but most strongly in interleukin-1...
Iron-binding fragments from the N-terminal and C-terminal regions of human lactoferrin.
Bluard-Deconinck, J M, Williams, J, Evans, R W, Van Snick, J, Osinski, P A, Masson, P L
Digestion of lactoferrin with pepsin at pH3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%-iron-saturated...
Expression cloning of the murine and human interleukin 9 receptor cDNAs.
Renauld, J C, Druez, C, Kermouni, A, Houssiau, F, Uyttenhove, C, Van Roost, E, ...
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression...
Interleukin-9 Enhances Resistance to the Intestinal Nematode Trichuris muris
Faulkner, Helen, Van Snick, J., Grencis, R. K.
Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In...
Khan, W. I., Richard, M., Akiho, H., Blennerhasset, P. A., Humphreys, N. E., Grencis, R. K., ...
Immune responses associated with intestinal nematode infections are characterized by the activation of T-helper 2 (Th2) cells. Previous studies demonstrated that during Trichinella spiralis...
Demoulin, J B, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, ...
Interleukin-9 (IL-9), a T-cell-derived cytokine, interacts with a specific receptor associated with the IL-2 receptor gamma chain. In this report, we analyze the functional domains of the human IL-9...
Uyttenhove, C, Simpson, R J, Van Snick, J
Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the...
Van Snick, J, Cayphas, S, Vink, A, Uyttenhove, C, Coulie, P G, Rubira, M R, ...
A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas. Hybrids that failed to survive in the absence of this molecule represented a major...
Poupart, P, Vandenabeele, P, Cayphas, S, Van Snick, J, Haegeman, G, Kruys, V, ...
The human "26-kd protein' is a secreted glycoprotein expressed, for example, in (blood) leukocytes, in epithelial cells treated with various inducers, but most strongly in interleukin-1...
Iron-binding fragments from the N-terminal and C-terminal regions of human lactoferrin.
Bluard-Deconinck, J M, Williams, J, Evans, R W, Van Snick, J, Osinski, P A, Masson, P L
Digestion of lactoferrin with pepsin at pH3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%-iron-saturated...
Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6.
Hültner, L, Szöts, H, Welle, M, Van Snick, J, Moeller, J, Dörmer, P
This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from...
Binding of in vivo formed immune complexes by monoclonal mouse rheumatoid factors
Coutelier, J. P., Van Snick, J.
Mouse rheumatoid factors (RF) have previously been shown to bind immune complexes formed in vitro with greater affinity than monomeric IgG. The present report extends this observation and shows that...
Houssiau, F A, Bukasa, K, Sindic, C J, Van Damme, J, Van Snick, J
We reported recently that a human protein, previously described as IL-1 inducible 26K factor (26K) or interferon-beta 2, was a potent growth factor for B cell hybridomas in vitro. Subsequently, it...
IL-9 promotes anti-Mycobacterium leprae cytotoxicity: involvement of IFNγ
Finiasz, M R, Franco, M C, Rutitzky, L, Pizzariello, G, ...
Interleukin 9 (IL-9) is a T-cell derived factor preferentially expressed by CD4+ Th2 cells and it has been characterized both in human and murine systems. It is a pleiotropic cytokine with multiple...