The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. (2008)
Holloway, J.W., Barton, S.J, Holgate, S.T ., Rose-Zerilli, M.J., Sayers, I.
Leukotrienes (LTs) have been identified as central mediators in asthma and allergy. Pharmacological inhibition of cysteinyl-LT activity improves asthma symptoms and control. Accumulating evidence...
Konstantinidis, A.K., Puddicombe, S.M., Mochizuki, A., Sheth, P.D., Yang, I.A., Yoshisue, H., ...
BACKGROUND: Interleukin (IL) 13 is a key cytokine in asthma, regulating fibrosis, airway remodeling, induction of immunoglobulin E synthesis by B cells, bronchial hyperresponsiveness, and mucus...
Holgate, S.T., Davies, D.E., Powell, R.M., Howarth, P.H., Haitchi, H.M., Holloway, J.W.
While asthma is an inflammatory disorder of the airways usually associated with atopy, an important additional component is involvement of the epithelium and underlying mesenchyme acting as a trophic...
Konstantinidis, A.K., Barton, S.J., Sayers, I., Yang, I.A., Lordan, J.L., Rorke, S., ...
Interleukin (IL)-13 plays a central role in asthma pathogenesis by binding to the IL-13 receptor, which is a heterodimer composed of the IL-13 receptor alpha1 subunit (IL-13Ralpha1) and IL-4Ralpha....
Gene-environmental interaction in asthma (2007)
Yang, I.A., Savarimuthu, S., Kim, S.T., Holloway, J.W., Bell, S.C., Fong, K.M.
Purpose of Review: Asthma is likely to result from the effects of environmental stimuli in genetically susceptible individuals. This review summarizes recent studies of gene-environmental interaction...
Gene-environmental interaction in asthma (2007)
Yang, I.A., Savarimuthu,S., Kim, S.T., Holloway, J.W, Bell, S.C., Fong, K.W.
Association of TNF-alpha genetic polymorphism with HLA DPB1*0301 (2006)
Kim, S.H., Ye, Y.M., Lee, S.K., Choi, J.H., Holloway, J.W., Park, C.S., ...
BACKGROUND: We speculated TNF-alpha can be one of candidate gene for aspirin-intolerant asthma (AIA) because TNF-alpha is pro-inflammatory cytokine and known to be increased level in asthmatic...
Kim, S.H., Bae, J.S., Holloway, J.W., Lee, J.T., Suh, C.H., Nahm, D.H., ...
BACKGROUND AND OBJECTIVE: The MS4A2 gene, the β chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The beta-chain of FcepsilonR1 enhances...
Hao, L., Sayers, I., Cakebread, J.A., Barton, S.J., Begh, B., Holgate, S.T., ...
BACKGROUND: The cysteinyl-leukotriene receptor type 1 (CysLT1) mediates the bronchoconstrictor and pro-inflammatory actions of cysteinyl-leukotrienes (LTC4, LTD4, LTE4) in asthma and is the molecular...
Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, K. M., Barton, S. J., Holloway, J. W., Yang, I. A., Cakebread, J. A., Cruikshank, W., ...
Single region linkage analyses of asthma: description of data sets (2001)
Palmer, L.J., Cookson, W.O., Deichmann, K.A., Holloway, J.W., Laitinen, T.
Linkage (genotypic) data from the 5q31-33 candidate region for asthma were contributed to Genetic Analysis Workshop 12 by members of the International Consortium on Asthma Genetics (COAG). Data came...