J. W. Konturek

Gastric electrical stimulation in intractable symptomatic gastroparesis (2003)

Abrahamsson, Hasse, Huizinga, Jan D, Konturek, J W, Galmiche, Jean Paul, ...

BACKGROUND: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessed...

Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion in humans.

Konturek, J W, Hengst, K, Kulesza, E, Gabryelewicz, A, Konturek, S J, Domschke, W

BACKGROUND: Nitric oxide (NO) is an unstable vasodilator formed by NO synthetase (NOS) from L-arginine (L-Arg) in various cells but its role in the control of pancreatic secretion in humans has not...

Cholecystokinin in the control of gastric acid secretion in man.

Konturek, J W, Stoll, R, Konturek, S J, Domschke, W

This study was designed to determine the role of cholecystokinin in the control gastric acid secretion in men using loxiglumide, a specific cholecystokinin receptor blocker. Three groups of healthy...

Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth, and neutrophil activation.

Konturek, J W, Dembinski, A, Stoll, R, Domschke, W, Konturek, S J

The gastropathy associated with the ingestion of non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin is a common side effect of this class of drugs, but the precise mechanisms by which...

Effects of non-peptidal CCK receptor antagonist (L-364,718) on pancreatic responses to cholecystokinin, gastrin, bombesin, and meat feeding in dogs.

Konturek, S J, Tasler, J, Konturek, J W, Cieszkowski, M, Szewczyk, K, Hładij, M, ...

Postprandial pancreatic secretion results from the interaction of neural and hormonal factors but their contribution to the net postprandial secretion is unknown. Recent description of highly...

Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.

Konturek, J W, Gillessen, A, Konturek, S J, Domschke, W

Helicobacter pylori infection may be associated with duodenal ulcer (DU) and accompanied by enhanced gastrin release but the mechanism of this H pylori related hypergastrinaemia in DU patients is...

Vagal cholinergic control of gastric alkaline secretion in normal subjects and duodenal ulcer patients.

Konturek, S J, Kwiecień, N, Obtułowicz, W, Thor, P, Konturek, J W, Popiela, T, ...

Gastric alkaline secretion was determined in ranitidine treated healthy subjects and duodenal ulcer (DU) patients using gastric perfusion aspiration system and back titration of gastric perfusate to...

CCK receptor antagonism by loxiglumide and gall bladder contractions in response to cholecystokinin, sham feeding and ordinary feeding in man.

Konturek, J W, Konturek, S J, Kurek, A, Bogdal, J, Oleksy, J, Rovati, L

The postprandial contractions of the gall bladder result from the interaction of neurohormonal factors but their relative contribution is unknown. This study was designed to determine the role of...

Distribution and release of epidermal growth factor in man.

Konturek, J W, Bielanski, W, Konturek, S J, Bogdal, J, Oleksy, J

Epidermal growth factor (EGF) is localised in man to salivary and Brunner's glands. It is present in large concentrations in saliva and duodenal contents but the mechanisms of its release have been...