Upstream Influence of a Porous Screen on the Flow Field of a Free Jet (2007)
This paper investigates the upstream influence of a range of transverse porous screen geometries on the flow fields of free jets. Infrared thermography was used to map the vertical distribution of...
Numerical Analysis of Flapping Wing Aerodynamics (2007)
Ashraf, M. A., Lai, J. C. S., Young, J.
Flapping-wing aerodynamics recently has generated a great deal of interest and increasing research effort because of the potential application in micro-air vehicles. The objective of this study is to...
DPOAE Changes in Young Children With Confirmed Hearing Loss Due to Ototoxicity (2007)
Beahan, N., Reichman, E., Kei, K., Driscoll, C., Young, J., Suppiah, R., ...
Edirippulige, S, Smith, AC, Young, J, Wootton, R
We surveyed all nurses working at a tertiary paediatric hospital (except casual staff and those who were on leave) from 27 hospital departments. A total of 365 questionnaires were distributed. There...
Optical fibre biosensors for oxygen and glucose monitoring (2005)
Young, J., Scully, P., Kvasnik, F., Rose, K., Kuncova, G., Podrazky, O., ...
An optical fibre biosensor that uses an oxygen sensitive coating; Ruthenium complex [Dichlorotris(1,10-phenantroline)-ruthenium(II) hydrate], incorporated into an adhesive inorganic-organic hybrid...
Nutritional status and energy expenditure in children pre-bone-marrow-transplant (2005)
White, M, Murphy, AJ, Hastings, Y, Shergold, J, Young, J, Montgomery, C, ...
The aims of this study were to establish the nutritional status of children pre- BMT and to determine whether predictive methods of assessing nutritional status and resting energy expenditure ( REE)...
High-frequency (1000 Hz) tympanometry in normal neonates (2003)
Kei, K.K.J., Allison-Levick, J., Dockray, J., Harrys, R., Kirkegard, C., Wong, J., ...
APC mutation and tumour budding in colorectal cancer (2003)
Jass, JR, Barker, M, Fraser, L, Walsh, MD, Whitehall, VLJ, Gabrielli, B, ...
Aim: To determine the frequency of tumour budding and somatic APC mutation in a series of colorectal cancers stratified according to DNA microsatellite instability (MSI) status. Material/Methods:...
Neonatal transient evoked otoacoustic emissions screening: How many stimuli are enough? (2002)
Cropper, L., Kei, K.K.J., Smyth, V., Maurer, M, Young, J., Tudehope, D., ...
High frequency (1000 Hz) tympanometric findings in neonates: a normative study (2002)
Kei, K.K.J., Allison-Levick, J., Dockray, J., Harrys, R., Kirkegard, C., Wong, J., ...
Jass, JR, Walsh, MD, Barker, M, Simms, LA, Young, J, Leggett, BA
Attempts to classify colorectal cancer into subtypes based upon molecular characterisation are overshadowed by the classical stepwise model in which the adenoma-carcinoma sequence serves as the...
Evolution of colorectal cancer: Change of pace and change of direction (2002)
Jass, JR, Young, J, Leggett, BA
This review compiles evidence for an alternative to the classical adenoma-carcinoma sequence in the evolution of colorectal cancer. It is suggested that between 30 and 50% of colorectal cancers are...
Emerging concepts in colorectal neoplasia (2002)
Jass, JR, Whitehall, VLJ, Young, J, Leggett, BA
An understanding of the mechanisms that explain the initiation and early evolution of colorectal cancer should facilitate the development of new approaches to effective prevention and intervention....
Whitehall, VLJ, Wynter, CVA, Walsh, MD, Simms, LA, Purdie, D, Pandeya, N, ...
Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular...
Hyperplastic polyposis - Association with colorectal cancer (2001)
Leggett, BA, Devereaux, B, Biden, K, Searle, J, Young, J, Jass, J
Hyperplastic polyposis is a loosely defined syndrome initially thought not to confer a clinically important predisposition to colorectal cancer. The aim of the current study was to examine the...
Whitehall, V. L. J., Walsh, M. D., Young, J., Leggett, B. A., Jass, J. R.
The significance of low-level DNA microsatellite instability (MSI-L) is not well understood. K-ras mutation is associated with MSI-L colorectal cancer and with the silencing of the DNA repair gene...
Biological significance of microsatellite instability-low (MSI-L) status in colorectal tumors (2001)
p73 is up-regulated in a subset of hepatocellular carcinomas (2000)
Herath, NI, Kew, MC, Whitehall, VLJ, Walsh, MD, Jass, JR, Khanna, KK, ...
Loss of heterozygosity (LOH) at 1p36 occurs in a number of solid tumors including hepatocellular carcinoma (HCC). Recently, a novel gene, p73, has been identified at 1p36.33. p73 is structurally and...
Detection of telomerase activity in biopsy samples of colorectal cancer (1999)
Fang, D. C., Young, J., Luo, Y. H., Lu, R., Jass, J. R.
Background: Telomerase is a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends. The expression of telomerase is thought to be required for cellular immortality and oncogenesis....
Iino, H., Jass, J. R., Simms, L. A., Young, J., Leggett, B., Ajioka, Y., ...
Aim-To investigate the distribution of DNA microsatellite instability (MSI) in a series of hyperplastic polyps, serrated adenomas, and mixed polyps of the colorectum. Methods-DNA was extracted from...
Jass, J. R., Biden, K. G., Cummings, M. C., Simms, L. A., Walsh, M., Schoch, E., ...
Background-10% of sporadic colorectal cancers are characterised by a low level of microsatellite instability (MSI-L). These are not thought to differ substantially from microsatellite-stable (MSS)...
Wynter, C. V. A., Simms, L. A., Buttenshaw, R. L., Biden, K. G., Young, J., Leggett, B. A., ...
Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are two important determinants of angiogenesis in human cancers. Expression of VEGF and bFGF was examined by...
Macdonald, GA, Tarish, J, Whitehall, VJL, McCann, SJ, Mellick, GD, Buttenshaw, RL, ...
Back ground and Aims: Previous studies have suggested that increased body iron stores and heterozygosity for haemochromatosis are associated with an increased risk of colorectal carcinoma. The aim of...
Cox, S., Wilcock, P., Young, J.
PROBLEM: A need to improve service to patients by reducing the time wasted by reception staff so that the 48 hour target for processing repeat prescription requests for patient collection could be...