Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin
Torres, AM, Bansal, P, Alewood, PF, Bursill, JA, Kuchel, PW, Vandenberg, JI
The three-dimensional structure of chemically synthesized CnErg1 (Ergtoxin), which specifically blocks HERG (human ether-a-go-go-related gene) K+ channels, was determined by nuclear magnetic...
Torres, AM, Bansal, PS, Sunde, M, Clarke, CE, Bursill, JA, Smith, DJ, ...
The HERG K+ channel has very unusual kinetic behavior that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarization as well as in preventing...