Structural Polymorphism of 441-Residue Tau at Single Residue Resolution (2009)
Marco D. Mukrasch, Stefan Bibow, Jegannath Korukottu, Sadasivam Jeganathan, Jacek Biernat, Christian Griesinger, ...
Alzheimer disease is characterized by abnormal protein deposits in the brain, such as extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made of a protein called...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons (2004)
Mandelkow, Eva-Maria, Thies, Edda, Trinczek, Bernhard, Biernat, Jacek, Mandelkow, Eckhard
Pickhardt, Marcus, Gazova, Zuzana, Von Bergen, Martin, Khlistunova, Inna, Wang, Yipeng, Hascher, Antje, ...
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Biernat, Jacek, Hasselmann, Hanne, Hofer, Bernd, Kennedy, Nick, Köster, Hubert
Synthetic genes coding for artificial proteins with predeflned and nutritionally valuable amino acid compositions have been constructed and cloned In bacterial plasmid vector pKK233-2. The genes were...
Biernat, Jacek, Köster, Hubert
Synthetic genes (A, AB and AHB) constructed and cloned into pKK233-2 vector were recloned from the parent plasmid into the new procaryotic expression vectors pGFY221N and pBIO52. Gene AF−B (coding...
Biernat, Jacek, Mandelkow, Eva-Maria
The differentiation of neurons and the outgrowth of neurites depends on microtubule-associated proteins such as tau protein. To study this process, we have used the model of Sf9 cells, which allows...
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides
Goldsbury, Claire, Mocanu, Maria-Magdalena, Thies, Edda, Kaether, Christoph, Haass, Christian, Keller, Patrick, ...
Amyloid-β, a peptide derived from the precursor protein APP, accumulates in the brain and contributes to the neuropathology of Alzheimer's disease. Increased generation of amyloid-β might be caused...
Biernat, Jacek, Mandelkow, Eva-Maria
The differentiation of neurons and the outgrowth of neurites depends on microtubule-associated proteins such as tau protein. To study this process, we have used the model of Sf9 cells, which allows...
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
Mandelkow, Eva-Maria, Thies, Edda, Trinczek, Bernhard, Biernat, Jacek, Mandelkow, Eckard
Microtubule-dependent transport of vesicles and organelles appears saltatory because particles switch between periods of rest, random Brownian motion, and active transport. The transport can be...
Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules
Felgner, Harald, Frank, Rainer, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Ludin, Beat, ...
Microtubules are flexible polymers whose mechanical properties are an important factor in the determination of cell architecture and function. It has been proposed that the two most prominent...
Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
Mukrasch, Marco D, Bibow, Stefan, Korukottu, Jegannath, Jeganathan, Sadasivam, Biernat, Jacek, Griesinger, Christian, ...
Alzheimer disease is characterized by abnormal protein deposits in the brain, such as extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made of a protein called...