Jacek Lubelski

Directionality and Coordination of Dehydration and Ring Formation during Biosynthesis of the Lantibiotic Nisin (2009)

Lubelski, Jacek, Khusainov, Rustem, Kuipers, Oscar P.

The lantibiotic nisin is a potent antimicrobial substance, which contains unusual lanthionine rings and dehydrated amino acid residues and is produced by Lactococcus lactis. Recently, the nisin...

LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis (2008)

Agustiandari, Herfita, Lubelski, Jacek, Kuipers, Oscar P., Driessen, Arnold J.M.

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a ΔlmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD...

The ABC-Type Multidrug Resistance Transporter LmrCD Is Responsible for an Extrusion-Based Mechanism of Bile Acid Resistance in Lactococcus lactis (2008)

Zaidi, Arsalan Haseeb, Bakkes, Patrick J., Lubelski, Jacek, Agustiandari, Herfita, Kuipers, Oscar P., Driessen, Arnold J.M.

Upon prolonged exposure to cholate and other toxic compounds, Lactococcus lactis develops a multidrug resistance phenotype that has been attributed to an elevated expression of the heterodimeric...

Influence of Shifting Positions of Ser, Thr, and Cys Residues in Prenisin on the Efficiency of Modification Reactions and on the Antimicrobial Activities of the Modified Prepeptides (2008)

Lubelski, Jacek, Overkamp, Wout, Kluskens, Leon D., Moll, Gert N., Kuipers, Oscar P.

Since the recent discovery that the nisin modification and transport machinery can be used to produce and modify peptides unrelated to nisin, specific questions arose concerning the specificity of...

Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria (2007)

Lubelski, Jacek, Konings, Wil N., Driessen, Arnold J.M.

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric (2006)

Lubelski, Jacek, Merkerk, Ronald Van, Konings, Wil N., Driessen, Arnold J.M.

LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug...

LmrCD is a major multidrug resistance transporter in Lactococcus lactis (2006)

Lubelski, Jacek, Jong, Anne De, Merkerk, Ronald Van, Agustiandari, Herfita, Kuipers, Oscar P., Kok, Jan, ...

When Lactococcus lactis is challenged with drugs it displays a multidrug resistance (MDR) phenotype. In silico analysis of the genome of L. lactis indicates the presence of at least 40 putative MDR...

Functional analysis of LmrCD, an ABC-type MDR transporter from Lactococcus lactis (2006)

Lubelski, Jacek

Bacterien die hun omgeving delen met concurrenten hebben een groot aantal strategieen ontwikkeld om toxische stoffen te kunnen weerstaan. Zulke beschermingsstrategieen zijn vaak gericht tegen een...

Functional analysis of LmrCD, an ABC-type MDR transporter from Lactococcus lactis / (2006)

Lubelski, Jacek.

Proefschrift Rijksuniversiteit Groningen.

Proton Motive Force-Dependent Hoechst 33342 Transport by the ABC Transporter LmrA of Lactococcus lactis (2005)

Lubelski, Jacek, Merkerk, Ronald Van, Mazurkiewicz, Piotr S., Driessen, Arnold J.M.

The fluorescent compound Hoechst 33342 is a substrate for many multidrug resistance (MDR) transporters and is widely used to characterize their transport activity. We have constructed mutants of the...

ydaG and ydbA of Lactococcus lactis Encode a Heterodimeric ATP-binding Cassette-type Multidrug Transporter (2004)

Lubelski, Jacek, Mazurkiewicz, Piotr, Merkerk, Ronald Van, Konings, Wil N., Driessen, Arnold J.M.

Multidrug resistance (MDR)-type transporters mediate the active extrusion of structurally and functionally dissimilar compounds from the cells, thereby rendering cells resistant to a range of drugs....

LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis▿

Agustiandari, Herfita, Lubelski, Jacek, Kuipers, Oscar P., Driessen, Arnold J. M.

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a ΔlmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD...

Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria

Lubelski, Jacek, Konings, Wil N., Driessen, Arnold J. M.

Summary: Membrane proteins responsible for the active efflux of structurally and functionally unrelated drugs were first characterized in higher eukaryotes. To date, a vast number of transporters...

Influence of Shifting Positions of Ser, Thr, and Cys Residues in Prenisin on the Efficiency of Modification Reactions and on the Antimicrobial Activities of the Modified Prepeptides▿ †

Lubelski, Jacek, Overkamp, Wout, Kluskens, Leon D., Moll, Gert N., Kuipers, Oscar P.

Since the recent discovery that the nisin modification and transport machinery can be used to produce and modify peptides unrelated to nisin, specific questions arose concerning the specificity of...

The ABC-Type Multidrug Resistance Transporter LmrCD Is Responsible for an Extrusion-Based Mechanism of Bile Acid Resistance in Lactococcus lactis▿

Zaidi, Arsalan Haseeb, Bakkes, Patrick J., Lubelski, Jacek, Agustiandari, Herfita, Kuipers, Oscar P., Driessen, Arnold J. M.

Upon prolonged exposure to cholate and other toxic compounds, Lactococcus lactis develops a multidrug resistance phenotype that has been attributed to an elevated expression of the heterodimeric...