The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids (2009)
Lisa Longato, Ming Tong, Sarah DeNucci, Jack R. Wands
Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced...
Lahousse, Stephanie A, Carter, Jade J, Xu, Xaolai J, Wands, Jack R, De La Monte, Suzanne M
Abstract Background Aspartyl (asparaginyl)-β-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation. This...
Derdák, Zoltán, Fülöp, Péter, Sabo, Edmond, Tavares, Rose, Berthiaume, Eric P., Resnick, Murray B., ...
Oxidative stress has a complex effect on cancer development. To further study this process, we induced colon tumors with azoxymethane (AOM) in mice deficient for uncoupling protein-2 (UCP2). UCP2 has...
Derdák, Zoltán, Fülöp, Péter, Sabo, Edmond, Tavares, Rose, Berthiaume, Eric P., Resnick, Murray B., ...
Oxidative stress has a complex effect on cancer development. To further study this process, we induced colon tumors with azoxymethane (AOM) in mice deficient for uncoupling protein-2 (UCP2). UCP2 has...
A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals
Tanaka, Shinji, Akiyoshi, Tsuyoshi, Mori, Masaki, Wands, Jack R., Sugimachi, Keizo
A novel member of the human frizzled (Fz) gene family was cloned and found to be specifically expressed in 3 of 13 well differentiated (23%), 13 of 20 moderately differentiated (62%), and 12 of 14...
Properties of Monoclonal Antibodies Directed against Hepatitis B Virus Polymerase Protein
Zu Putlitz, Jasper, Lanford, Robert E., Carlson, Rolf I., Notvall, Lena, De La Monte, Suzanne M., Wands, Jack R.
Hepadnavirus polymerases are multifunctional enzymes that play critical roles during the viral life cycle but have been difficult to study due to a lack of a well-defined panel of monoclonal...
Geissler, Michael, Bruss, Volker, Michalak, Sabine, Hockenjos, Birgit, Ortmann, Dörte, Offensperger, Wolf B., ...
We have previously shown that hepatitis B virus (HBV) surface antigens (HBsAgs) are highly immunogenic after genetic immunization. Compared to the secreted middle HBV surface proteins (MHBs) or small...
Melegari, Margherita, Scaglioni, Pier Paolo, Wands, Jack R.
The hepatitis B virus and the mammalian hepadnavirus genomes encode for a short open reading frame called x. Expression of the protein product (HBx) appears necessary for establishment of natural...
The Native Form and Maturation Process of Hepatitis C Virus Core Protein
Yasui, Kohichiroh, Wakita, Takaji, Tsukiyama-Kohara, Kyoko, Funahashi, Shin-Ichi, Ichikawa, Masumi, Kajita, Tadahiro, ...
The maturation and subcellular localization of hepatitis C virus (HCV) core protein were investigated with both a vaccinia virus expression system and CHO cell lines stably transformed with HCV cDNA....
Zu Putlitz, Jasper, Yu, Qiao, Burke, John M., Wands, Jack R.
A combinatorial screening method has been used to identify hairpin ribozymes that inhibit hepatitis B virus (HBV) replication in transfected human hepatocellular carcinoma (HCC) cells. A hairpin...
Carboxypeptidase D Is an Avian Hepatitis B Virus Receptor
Tong, Shuping, Li, Jisu, Wands, Jack R.
The receptor molecules for human and animal hepatitis B viruses have not been defined. Previous studies have described a 170 to 180 kDa molecule (p170 or gp180) that binds in vitro to the pre-S...
Spangenberg, Hans Christian, Lee, Hong Bock, Li, Jisu, Tan, Fulong, Skidgel, Randal, Wands, Jack R., ...
Virus-cell surface receptor interactions are of major interest. Hepadnaviruses are a family of partially double-stranded DNA viruses with liver tropism and a narrow host range of susceptibility to...
Glycine Decarboxylase Mediates a Postbinding Step in Duck Hepatitis B Virus Infection
Li, Jisu, Tong, Shuping, Lee, Hong Bock, Perdigoto, Ana Luisa, Spangenberg, Hans Christian, Wands, Jack R.
Envelope protein precursors of many viruses are processed by a basic endopeptidase to generate two molecules, one for receptor binding and the other for membrane fusion. Such a cleavage event has not...
Modulation of Hepatitis B Virus Secretion by Naturally Occurring Mutations in the S Gene
Khan, Nasser, Guarnieri, Michael, Ahn, Sang Hoon, Li, Jisu, Zhou, Yonghong, Bang, Genie, ...
Alteration in hepatitis B virus (HBV) secretion efficiency may have pathological consequences. Naturally occurring mutations that regulate virion secretion have not been defined. We recently...
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
Tanaka, Shinji, Mori, Masaki, Sakamoto, Yoshihiro, Makuuchi, Masatoshi, Sugimachi, Keizo, Wands, Jack R.
Human hepatocellular carcinoma (HCC) is generally a highly vascular tumor, but the mechanisms of neovascularization that permit rapid growth have not been defined. Angiopoietins (Ang) recently have...
Alteration in suppressor cell activity in chronic active hepatitis*
Hodgson, Humphrey J. F., Wands, Jack R., Isselbacher, Kurt J.
We have studied peripheral blood mononuclear cells obtained from 24 patients with acute or chronic active hepatitis to determine if there was an abnormality in concanavalin A-induced suppressor cell...
A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals
Tanaka, Shinji, Akiyoshi, Tsuyoshi, Mori, Masaki, Wands, Jack R., Sugimachi, Keizo
A novel member of the human frizzled (Fz) gene family was cloned and found to be specifically expressed in 3 of 13 well differentiated (23%), 13 of 20 moderately differentiated (62%), and 12 of 14...
Properties of Monoclonal Antibodies Directed against Hepatitis B Virus Polymerase Protein
Zu Putlitz, Jasper, Lanford, Robert E., Carlson, Rolf I., Notvall, Lena, De La Monte, Suzanne M., Wands, Jack R.
Hepadnavirus polymerases are multifunctional enzymes that play critical roles during the viral life cycle but have been difficult to study due to a lack of a well-defined panel of monoclonal...
Geissler, Michael, Bruss, Volker, Michalak, Sabine, Hockenjos, Birgit, Ortmann, Dörte, Offensperger, Wolf B., ...
We have previously shown that hepatitis B virus (HBV) surface antigens (HBsAgs) are highly immunogenic after genetic immunization. Compared to the secreted middle HBV surface proteins (MHBs) or small...
Melegari, Margherita, Scaglioni, Pier Paolo, Wands, Jack R.
The hepatitis B virus and the mammalian hepadnavirus genomes encode for a short open reading frame called x. Expression of the protein product (HBx) appears necessary for establishment of natural...
The Native Form and Maturation Process of Hepatitis C Virus Core Protein
Yasui, Kohichiroh, Wakita, Takaji, Tsukiyama-Kohara, Kyoko, Funahashi, Shin-Ichi, Ichikawa, Masumi, Kajita, Tadahiro, ...
The maturation and subcellular localization of hepatitis C virus (HCV) core protein were investigated with both a vaccinia virus expression system and CHO cell lines stably transformed with HCV cDNA....
Zu Putlitz, Jasper, Yu, Qiao, Burke, John M., Wands, Jack R.
A combinatorial screening method has been used to identify hairpin ribozymes that inhibit hepatitis B virus (HBV) replication in transfected human hepatocellular carcinoma (HCC) cells. A hairpin...
Carboxypeptidase D Is an Avian Hepatitis B Virus Receptor
Tong, Shuping, Li, Jisu, Wands, Jack R.
The receptor molecules for human and animal hepatitis B viruses have not been defined. Previous studies have described a 170 to 180 kDa molecule (p170 or gp180) that binds in vitro to the pre-S...
Spangenberg, Hans Christian, Lee, Hong Bock, Li, Jisu, Tan, Fulong, Skidgel, Randal, Wands, Jack R., ...
Virus-cell surface receptor interactions are of major interest. Hepadnaviruses are a family of partially double-stranded DNA viruses with liver tropism and a narrow host range of susceptibility to...
Glycine Decarboxylase Mediates a Postbinding Step in Duck Hepatitis B Virus Infection
Li, Jisu, Tong, Shuping, Lee, Hong Bock, Perdigoto, Ana Luisa, Spangenberg, Hans Christian, Wands, Jack R.
Envelope protein precursors of many viruses are processed by a basic endopeptidase to generate two molecules, one for receptor binding and the other for membrane fusion. Such a cleavage event has not...
Modulation of Hepatitis B Virus Secretion by Naturally Occurring Mutations in the S Gene
Khan, Nasser, Guarnieri, Michael, Ahn, Sang Hoon, Li, Jisu, Zhou, Yonghong, Bang, Genie, ...
Alteration in hepatitis B virus (HBV) secretion efficiency may have pathological consequences. Naturally occurring mutations that regulate virion secretion have not been defined. We recently...
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
Tanaka, Shinji, Mori, Masaki, Sakamoto, Yoshihiro, Makuuchi, Masatoshi, Sugimachi, Keizo, Wands, Jack R.
Human hepatocellular carcinoma (HCC) is generally a highly vascular tumor, but the mechanisms of neovascularization that permit rapid growth have not been defined. Angiopoietins (Ang) recently have...
Alteration in suppressor cell activity in chronic active hepatitis*
Hodgson, Humphrey J. F., Wands, Jack R., Isselbacher, Kurt J.
We have studied peripheral blood mononuclear cells obtained from 24 patients with acute or chronic active hepatitis to determine if there was an abnormality in concanavalin A-induced suppressor cell...
Gehring, Stephan, Gregory, Stephen H., Wintermeyer, Philip, Aloman, Costica, Wands, Jack R.
Dendritic cells (DCs) internalize and process antigens as well as activate cellular immune responses. The aim of this study was to determine the capacity of DCs that contain antigen-coated magnetic...
The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids
De La Monte, Suzanne M., Longato, Lisa, Tong, Ming, DeNucci, Sarah, Wands, Jack R.
Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced...
Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed
De La Monte, Suzanne M., Wands, Jack R.
Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; amyloid precursor...