Jacob C. Koella

Effects of shortened host life span on the evolution of parasite life history and virulence in a microbial host-parasite system (2009)

Nidelet, Thibault, Koella, Jacob C, Kaltz, Oliver

Abstract Background Ecological factors play an important role in the evolution of parasite exploitation strategies. A common prediction is that, as shorter host life span reduces future opportunities...

Intra-specific variation of sperm length in the malaria vector Anopheles gambiae: males with shorter sperm have higher reproductive success (2008)

Voordouw, Maarten J, Koella, Jacob C, Hurd, Hilary

Abstract Background Intra-specific variation in sperm length influences male reproductive success in several species of insects. In males of the malaria vector Anopheles gambiae , sperm length is...

Comparison of male reproductive success in malaria-refractory and susceptible strains of Anopheles gambiae (2008)

Voordouw, Maarten J, Koella, Jacob C, Hurd, Hilary

Abstract Background In female mosquitoes that transmit malaria, the benefits of being refractory to the Plasmodium parasite are balanced by the immunity costs in the absence of infection. Male...

Genetic variation of male reproductive success in a laboratory population of Anopheles gambiae (2007)

Voordouw, Maarten J, Koella, Jacob C

Abstract Background For Anopheline mosquitoes, the vectors of human malaria, genetic variation in male reproductive success can have important consequences for any control strategy based on the...

A major genetic locus controlling natural Plasmodium falciparuminfection is shared by East and West African Anopheles gambiae (2007)

Riehle, Michelle M, Markianos, Kyriacos, Lambrechts, Louis, Xia, Ai, Sharakhov, Igor, Koella, Jacob C, ...

Abstract Background Genetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum . This 2L...

Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiale and Anopheles funestus (2007)

Koella, Jacob C., Annan, Zeinab, Simard, Frederic, Renaud, Francois, Arnathau, Celine, Awono-Ambene, Parfait, ...

We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught...

Malaria Infection Increases Attractiveness of Humans to Mosquitoes (2005)

Renaud Lacroix, Wolfgang R. Mukabana, Louis Clement Gouagna, Jacob C. Koella

A study of children in Kenya reveals that those individuals harboring the transmissible gametocyte stage of malaria parasites are more attractive to the mosquito vectors that spread this disease.

Malaria Infection Increases Attractiveness of Humans to Mosquitoes (2005)

Renaud Lacroix, Wolfgang R. Mukabana, Louis Clement Gouagna, Jacob C. Koella

Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been...

Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum (2005)

Lambrechts, Louis, Halbert, Jean, Durand, Patrick, Gouagna, Louis C, Koella, Jacob C

Abstract Background Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural...

GENETIC CORRELATION BETWEEN MELANIZATION AND ANTIBACTERIAL IMMUNE RESPONSES IN A NATURAL POPULATION OF THE MALARIA VECTOR ANOPHELES GAMBIAE (2004)

Louis Lambrechts, John M. Vulule, Jacob C. Koella

The immune system of invertebrates can mount different responses, including melanotic encapsulation and several antibacterial defense mechanisms. Variation of the efficacies of these responses is...

HOST GROWTH CONDITIONS REGULATE THE PLASTICITY OF HORIZONTAL AND VERTICAL TRANSMISSION IN HOLOSPORA UNDULATA, A BACTERIAL PARASITE OF THE PROTOZOAN PARAMECIUM CAUDATUM (2003)

Oliver Kaltz, Jacob C. Koella

A parasite might be prohibited from investing simultaneously in horizontal (infection of new hosts) and vertical (infection of the current host's offspring) transmission because of developmental,...

Sub-lethal effects of pathogens can lead to the evolution of lower virulence in multiple infections (2003)

Schjørring,Solveig, Koella,Jacob C.

According to current evolutionary dogma, multiple infections generally increase a parasite's virulence (i.e. reduce the host's reproductive success). The basic idea is that the competitive...

Sub-lethal effects of pathogens can lead to the evolution of lower virulence in multiple infections (2003)

Schjørring, Solveig, Koella, Jacob C.

According to current evolutionary dogma, multiple infections generally increase a parasite's virulence (i.e. reduce the host's reproductive success). The basic idea is that the competitive...

A GENETIC CORRELATION BETWEEN AGE AT PUPATION AND MELANIZATION IMMUNE RESPONSE OF THE YELLOW FEVER MOSQUITO AEDES AEGYPTI (2002)

Jacob C. Koella, Christophe Boëte

To investigate the evolutionary cost of an immune response, we selected six lines of the mosquito Aedes aegypti for earlier or later pupation and measured the extent to which this selection procedure...

A theoretical approach to predicting the success of genetic manipulation of malaria mosquitoes in malaria control (2002)

Boëte, Christophe, Koella, Jacob C

Abstract Background Mosquitoes that have been genetically modified to better encapsulate the malaria parasite Plasmodium falciparum are being considered as a possible tool in the control of malaria....

Melanization of Plasmodium falciparum and C-25 Sephadex Beads by Field-Caught Anopheles gambiae (Diptera: Culicidae) from Southern Tanzania (2002)

Alex Schwartz, Jacob C. Koella

The melanization responses of field-captured Anopheles gambiae s.l. toward oocysts of the malaria parasite Plasmodium falciparum or negatively charged (C-25) Sephadex beads were determined. Only two...

Stage-specific manipulation of a mosquito's host-seeking behavior by the malaria parasite Plasmodium gallinaceum (2002)

Koella, Jacob C., Rieu, Linda, Paul, Richard E. L.

We present experimental evidence that different stages of the malaria parasite Plasmodium gallinaceum differentially affect the host-seeking behavior of its mosquito vector Aedes aegypti. In...

Malaria Infection Increases Attractiveness of Humans to Mosquitoes

Lacroix, Renaud, Mukabana, Wolfgang R, Gouagna, Louis Clement, Koella, Jacob C

Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been...

Malaria Infection Increases Attractiveness of Humans to Mosquitoes

Lacroix, Renaud, Mukabana, Wolfgang R, Gouagna, Louis Clement, Koella, Jacob C

Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been...

Sub-lethal effects of pathogens can lead to the evolution of lower virulence in multiple infections.

Schjørring, Solveig, Koella, Jacob C

According to current evolutionary dogma, multiple infections generally increase a parasite's virulence (i.e. reduce the host's reproductive success). The basic idea is that the competitive...

Direct and indirect immunosuppression by a malaria parasite in its mosquito vector.

Boëte, Christophe, Paul, Richard E L, Koella, Jacob C

Malaria parasites develop as oocysts within the haemocoel of their mosquito vector during a period that is longer than the average lifespan of many of their vectors. How can they escape from the...

Environmental influence on the genetic basis of mosquito resistance to malaria parasites

Lambrechts, Louis, Chavatte, Jean-Marc, Snounou, Georges, Koella, Jacob C

The genetic basis of a host's resistance to parasites has important epidemiological and evolutionary consequences. Understanding this genetic basis can be complicated by non-genetic factors, such as...

Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus

Annan, Zeinab, Durand, Patrick, Ayala, Francisco J., Arnathau, Céline, Awono-Ambene, Parfait, Simard, Frédéric, ...

We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught...