Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion (2006)
Gallo, Stephen A, Reeves, Jacqueline D, Garg, Himanshu, Foley, Brian, Doms, Robert W, Blumenthal, Robert
Abstract Background HIV envelope glycoprotein (Env)-mediated fusion is driven by the concerted coalescence of the HIV gp41 N-helical and C-helical regions, which results in the formation of 6 helix...
Marozsan, Andre J., Moore, Dawn M., Lobritz, Michael A., Fraundorf, Erika, Abraha, Awet, Reeves, Jacqueline D., ...
The ability of one primary human immunodeficiency virus type 1 (HIV-1) isolate to outcompete another in primary CD4+ human lymphoid cells appears to be mediated by the efficiency of host cell entry....
Reeves, Jacqueline D, Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Vödrös, Dalma, Thorstensson, Rigmor, Doms, Robert W, Fenyö, Eva Maria, Reeves, Jacqueline D
Abstract is not available
Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, ...
Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to...
McKnight, Áine, Dittmar, Matthias T., Moniz-Periera, José, Ariyoshi, Koya, Reeves, Jacqueline D., Hibbitts, Sam, ...
Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Pöhlmann, Stefan, Leslie, George J., Edwards, Terri G., Macfarlan, Todd, Reeves, Jacqueline D., Hiebenthal-Millow, Kirsten, ...
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that...
Edwards, Terri G., Wyss, Stéphanie, Reeves, Jacqueline D., Zolla-Pazner, Susan, Hoxie, James A., Doms, Robert W., ...
We have described a CD4-independent variant of HXBc2, termed 8x, that binds directly to CXCR4 and mediates CD4-independent virus infection. Determinants for CD4 independence map to residues in the V3...
Reeves, Jacqueline D., Gallo, Stephen A., Ahmad, Navid, Miamidian, John L., Harvey, Phoebe E., Sharron, Matthew, ...
HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents...
Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., ...
The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor...
Simmons, Graham, Reeves, Jacqueline D., Rennekamp, Andrew J., Amberg, Sean M., Piefer, Andrew J., Bates, Paul
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health. Here we describe conditions that result not...
Reeves, Jacqueline D., Miamidian, John L., Biscone, Mark J., Lee, Fang-Hua, Ahmad, Navid, Pierson, Theodore C., ...
An increasingly large number of antiviral agents that prevent entry of human immunodeficiency virus (HIV) into cells are in preclinical and clinical development. The envelope (Env) protein of HIV is...
Yuste, Eloísa, Reeves, Jacqueline D., Doms, Robert W., Desrosiers, Ronald C.
Specific mutations were created in the cytoplasmic domain of the gp41 transmembrane protein of simian immunodeficiency virus strain 239 (SIV239). The resultant strains included a mutant in which Env...
Reeves, Jacqueline D., Lee, Fang-Hua, Miamidian, John L., Jabara, Cassandra B., Juntilla, Marisa M., Doms, Robert W.
Enfuvirtide (ENF/T-20/Fuzeon), the first human immunodeficiency virus (HIV) entry inhibitor to be licensed, targets a structural intermediate of the entry process. ENF binds the HR1 domain in gp41...
Marozsan, Andre J., Moore, Dawn M., Lobritz, Michael A., Fraundorf, Erika, Abraha, Awet, Reeves, Jacqueline D., ...
The ability of one primary human immunodeficiency virus type 1 (HIV-1) isolate to outcompete another in primary CD4+ human lymphoid cells appears to be mediated by the efficiency of host cell entry....
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Simmons, Graham, Gosalia, Dhaval N., Rennekamp, Andrew J., Reeves, Jacqueline D., Diamond, Scott L., Bates, Paul
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion
Gallo, Stephen A, Reeves, Jacqueline D, Garg, Himanshu, Foley, Brian, Doms, Robert W, Blumenthal, Robert
Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, ...
Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to...
McKnight, Áine, Dittmar, Matthias T., Moniz-Periera, José, Ariyoshi, Koya, Reeves, Jacqueline D., Hibbitts, Sam, ...
Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Pöhlmann, Stefan, Leslie, George J., Edwards, Terri G., Macfarlan, Todd, Reeves, Jacqueline D., Hiebenthal-Millow, Kirsten, ...
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that...
Edwards, Terri G., Wyss, Stéphanie, Reeves, Jacqueline D., Zolla-Pazner, Susan, Hoxie, James A., Doms, Robert W., ...
We have described a CD4-independent variant of HXBc2, termed 8x, that binds directly to CXCR4 and mediates CD4-independent virus infection. Determinants for CD4 independence map to residues in the V3...
Reeves, Jacqueline D., Gallo, Stephen A., Ahmad, Navid, Miamidian, John L., Harvey, Phoebe E., Sharron, Matthew, ...
HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents...
Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...
The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...
Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., ...
The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor...
Simmons, Graham, Reeves, Jacqueline D., Rennekamp, Andrew J., Amberg, Sean M., Piefer, Andrew J., Bates, Paul
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health. Here we describe conditions that result not...
Reeves, Jacqueline D., Miamidian, John L., Biscone, Mark J., Lee, Fang-Hua, Ahmad, Navid, Pierson, Theodore C., ...
An increasingly large number of antiviral agents that prevent entry of human immunodeficiency virus (HIV) into cells are in preclinical and clinical development. The envelope (Env) protein of HIV is...
Yuste, Eloísa, Reeves, Jacqueline D., Doms, Robert W., Desrosiers, Ronald C.
Specific mutations were created in the cytoplasmic domain of the gp41 transmembrane protein of simian immunodeficiency virus strain 239 (SIV239). The resultant strains included a mutant in which Env...
Reeves, Jacqueline D., Lee, Fang-Hua, Miamidian, John L., Jabara, Cassandra B., Juntilla, Marisa M., Doms, Robert W.
Enfuvirtide (ENF/T-20/Fuzeon), the first human immunodeficiency virus (HIV) entry inhibitor to be licensed, targets a structural intermediate of the entry process. ENF binds the HR1 domain in gp41...
Marozsan, Andre J., Moore, Dawn M., Lobritz, Michael A., Fraundorf, Erika, Abraha, Awet, Reeves, Jacqueline D., ...
The ability of one primary human immunodeficiency virus type 1 (HIV-1) isolate to outcompete another in primary CD4+ human lymphoid cells appears to be mediated by the efficiency of host cell entry....
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Simmons, Graham, Gosalia, Dhaval N., Rennekamp, Andrew J., Reeves, Jacqueline D., Diamond, Scott L., Bates, Paul
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its...
Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion
Gallo, Stephen A, Reeves, Jacqueline D, Garg, Himanshu, Foley, Brian, Doms, Robert W, Blumenthal, Robert
Pastore, Cristina, Nedellec, Rebecca, Ramos, Alejandra, Hartley, Oliver, Miamidian, John L., Reeves, Jacqueline D., ...
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) envelope function during the process of coreceptor switching from CCR5 to CXCR4. Site-directed mutagenesis was used to...
Veazey, Ronald S., Klasse, Per Johan, Ketas, Thomas J., Reeves, Jacqueline D., Piatak, Michael, Kunstman, Kevin, ...
Human immunodeficiency virus type 1 (HIV-1) fuses with cells after sequential interactions between its envelope glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC...
Huang, Wei, Toma, Jonathan, Fransen, Signe, Stawiski, Eric, Reeves, Jacqueline D., Whitcomb, Jeannette M., ...
Many studies have demonstrated that the third variable region (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is a major determinant of coreceptor tropism. Other...