Jacqueline E. Payton

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia (2008)

Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D

Abstract Background Acute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role...

Corresponding Author: (2006)

Wenlin Yuan, Jacqueline E Payton, Matthew S Holt, Daniel C Link, Mark A Watson, John F Dipersio, ...

doi:10.1182/blood-2006-07-036640 Commonly dysregulated genes in murine APL cells

Commonly dysregulated genes in murine APL cells

Yuan, Wenlin, Payton, Jacqueline E., Holt, Matthew S., Link, Daniel C., Watson, Mark A., DiPersio, John F., ...

To identify genes that are commonly dysregulated in a murine model of acute promyelocytic leukemia (APL), we first defined gene expression patterns during normal murine myeloid development; serial...

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D

A dissection of the genetic networks and circuitries is described for two form of leukaemia. Integrating transcription factor binding and gene expression profiling, networks are revealed that underly...

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Tomasson, Michael H., Xiang, Zhifu, Walgren, Richard, Zhao, Yu, Kasai, Yumi, Miner, Tracie, ...

Activating mutations in tyrosine kinase (TK) genes (eg, FLT3 and KIT) are found in more than 30% of patients with de novo acute myeloid leukemia (AML); many groups have speculated that mutations in...

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

Xiang, Zhifu, Zhao, Yu, Mitaksov, Vesselin, Fremont, Daved H., Kasai, Yumi, Molitoris, AnnaLynn, ...

Somatic mutations in JAK2 are frequently found in myeloproliferative diseases, and gain-of-function JAK3 alleles have been identified in M7 acute myeloid leukemia (AML), but a role for JAK1 in AML...

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

Payton, Jacqueline E., Grieselhuber, Nicole R., Chang, Li-Wei, Murakami, Mark, Geiss, Gary K., Link, Daniel C., ...

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor α (RARA) gene to another gene, most commonly...

Acquired copy number alterations in adult acute myeloid leukemia genomes

Walter, Matthew J., Payton, Jacqueline E., Ries, Rhonda E., Shannon, William D., Deshmukh, Hrishikesh, Zhao, Yu, ...

Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the identification of genes important for AML pathogenesis. To complement cytogenetic studies and to identify genes altered...