Jafar Mahdavi

Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection (2008)

Sara Lindén, Jafar Mahdavi, Cristina Semino-Mora, Cara Olsen, Ingemar Carlstedt, Thomas Borén, ...

The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive...

Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics (2007)

Horlock, Claire, Shakib, Farouk, Mahdavi, Jafar, Jones, Nick S, Sewell, Herb F, Ghaemmaghami, Amir M

Abstract Background Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood...

Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays (2005)

Walz, Anke, Odenbreit, Stefan, Mahdavi, Jafar, Borén, Thomas, Ruhl, Stefan

The microaerophilic bacterium Helicobacter pylori is well established for its role in development of different gastric diseases. Bacterial adhesins and corresponding binding sites on the epithelial...

Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays (2005)

Walz, Anke, Odenbreit, Stefan, Mahdavi, Jafar, Borén, Thomas, Ruhl, Stefan

The microaerophilic bacterium Helicobacter pylori (H. pylori) is well established for its role in development of different gastric diseases. Bacterial adhesins and corresponding binding sites on the...

Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin (2004)

Aspholm-Hurtig, Marina, Dailide, Giedrius, Lahmann, Martina, Kalia, Awdhesh, Ilver, Dag, Roche, Niamh, ...

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens...

Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation (2004)

Mahdavi, Jafar

Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which...

Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation (2004)

Mahdavi, Jafar

Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which...

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation (2002)

Mahdavi, Jafar, Sondén, Berit, Hurtig, Marina, Olfat, Farzad O., Forsberg, Lina, Roche, Niamh, ...

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for...

Limited Role of Lipopolysaccharide Lewis Antigens in Adherence of Helicobacter pylori to the Human Gastric Epithelium

Mahdavi, Jafar, Borén, Thomas, Vandenbroucke-Grauls, Christina, Appelmelk, Ben J.

In vitro and in vivo studies from various groups have suggested that Helicobacter pylori lipopolysaccharide (LPS) Lewis x (Lex) antigens mediate bacterial adhesion. We have now reevaluated this...

Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins

Lindén, Sara, Mahdavi, Jafar, Hedenbro, Jan, Borén, Thomas, Carlstedt, Ingemar

Helicobacter pylori causes gastritis, peptic ulcer disease and gastric cancer. The microbe is found in the gastric mucus layer where a pH gradient ranging from acidic in the lumen to neutral at the...

Limited Role of Lipopolysaccharide Lewis Antigens in Adherence of Helicobacter pylori to the Human Gastric Epithelium

Mahdavi, Jafar, Borén, Thomas, Vandenbroucke-Grauls, Christina, Appelmelk, Ben J.

In vitro and in vivo studies from various groups have suggested that Helicobacter pylori lipopolysaccharide (LPS) Lewis x (Lex) antigens mediate bacterial adhesion. We have now reevaluated this...

Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins

Lindén, Sara, Mahdavi, Jafar, Hedenbro, Jan, Borén, Thomas, Carlstedt, Ingemar

Helicobacter pylori causes gastritis, peptic ulcer disease and gastric cancer. The microbe is found in the gastric mucus layer where a pH gradient ranging from acidic in the lumen to neutral at the...

Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection

Lindén, Sara, Mahdavi, Jafar, Semino-Mora, Cristina, Olsen, Cara, Carlstedt, Ingemar, Borén, Thomas, ...

The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive...

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

Orihuela, Carlos J., Mahdavi, Jafar, Thornton, Justin, Mann, Beth, Wooldridge, Karl G., Abouseada, Noha, ...

A diverse array of infectious agents, including prions and certain neurotropic viruses, bind to the laminin receptor (LR), and this determines tropism to the CNS. Bacterial meningitis in childhood is...