Angus, James A, Ferrier, Claudia P, Sudhir, Krishnankutty, Kaye, David M, Jennings, Garry L
Objective: The aim was to determine the pharmacological reactivity of human small resistance arteries in patients with cardiac failure. Methods: Small arteries (
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation
Li, Ming, Liu, Ke, Michalicek, Jan, Angus, James A., Hunt, John E., Dell’Italia, Louis J., ...
Angiotensin I–converting enzyme (ACE) inhibitors are thought to lower blood pressure in hypertensive patients, mainly by decreasing angiotensin II (Ang II) formation. Chymase, a human mast cell...
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation
Li, Ming, Liu, Ke, Michalicek, Jan, Angus, James A., Hunt, John E., Dell’Italia, Louis J., ...
Angiotensin I–converting enzyme (ACE) inhibitors are thought to lower blood pressure in hypertensive patients, mainly by decreasing angiotensin II (Ang II) formation. Chymase, a human mast cell...
Serone, Adrian P, Angus, James A, Wright, Christine E
Neuropeptide Y (NPY) may inhibit sympathetic and vagal transmission via presynaptic Y2 receptors and cause vasoconstriction via postsynaptic Y1 receptors. We examined the effects of NPY and related...
Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists
Sarsero, Doreen, Fujiwara, Toshimasa, Molenaar, Peter, Angus, James A
Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility.We compared four L-type calcium channel...
Heterogeneity of prejunctional NPY receptor-mediated inhibition of cardiac neurotransmission
Serone, Adrian P, Wright, Christine E, Angus, James A
Neuropeptide Y (NPY) has been proposed as the candidate inhibitory peptide mediating interactions between sympathetic and vagal neurotransmission in several species, including man. Here, we have...
Serone, Adrian P, Angus, James A
The effects of NPY and related peptides were examined on basal contractile force and nerve-mediated inotropic responses to electrical field stimulation of the guinea-pig isolated left...
Role of N-type calcium channels in autonomic neurotransmission in guineapig isolated left atria
Serone, Adrian P, Angus, James A
Calcium entry via neuronal calcium channels is essential for the process of neurotransmission. We investigated the calcium channel subtypes involved in the operation of cardiac autonomic...
Wright, Christine E, Robertson, Alan D, Whorlow, Sarah L, Angus, James A
The effects of a novel N-type voltage-operated calcium channel antagonist, ω-conotoxin CVID, were compared with ω-conotoxin MVIIA on sympathetic-evoked activation of right atria (RA), small...
Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens
Christopoulos, Arthur, Coles, Peter, Lay, Lucy, Lew, Michael J, Angus, James A
The interaction between the cannabinoid agonists, WIN 55,212-2 or CP 55,940 with the CB1 receptor-selective antagonists, SR141716A or LY320135 was investigated using the rat electrically-stimulated...
Xi, Qi, Ziogas, James, Roberts, Jonathan A, Evans, Richard J, Angus, James A
We investigated the role of voltage-operated calcium channels in sympathetic transmission and depolarization-induced contractions in the rat mesenteric artery. In particular, we investigated the role...
Charles, Julian, Angus, James A, Wright, Christine E
This study examined the role of histamine H3 receptors in vagal and sympathetic autonomic reflexes in the conscious rabbit, and in rabbit and guinea-pig isolated right atria.The baroreceptor-heart...
Tham, Shao M, Angus, James A, Tudor, Elizabeth M, Wright, Christine E
Cannabinoid receptor agonists elicit analgesic effects in acute and chronic pain states via spinal and supraspinal pathways. We investigated whether the combination of a cannabinoid agonist with...