Prolonged residence in the phagosomal compartment of host macrophages is essential for the establishment and maintenance of chronic infection by the brucellae in mammalian hosts. The intracellular...
A Role for TIMP-1 in Breast Cancer Progression (1998)
Breast cancer is the most common life-threatening cancer and second leading cause of cancer deaths in Western women. Death usually results from the complications caused by secondary tumors that...
A Role for TIMP-1 in Breast Cancer Progression (1998)
Cardelli, James A., Bigelow, Rebecca
The studies in this grant are designed to assess the role of TIMP-1 in invasion and metastasis with emphasis on the Ras signaling pathway. We have previously provided evidence that TIMP-1 may induce...
Phagosomal Proteins of Dictyostelium discoideum (1997)
Rezabek, Betsy L., Rodriguez-Paris, Juan M., Cardelli, James A., Chia, Catherine P.
In recognizing food particles, Dictyostelium cell-surface molecules initiate cytoskeletal rearrangements that result in phagosome formation. After feeding D. discoideum cells latex beads, early...
Temesvari, Lesly, Zhang, Linyi, Fodera, Brent, Janssen, Klaus-Peter, Schleicher, Michael, Cardelli, James A.
Profilin is a key phosphoinositide and actin-binding protein connecting and coordinating changes in signal transduction pathways with alterations in the actin cytoskeleton. Using biochemical assays...
Solomon, Jonathan M., Rupper, Adam, Cardelli, James A., Isberg, Ralph R.
Conditions were established in which Legionella pneumophila, an intracellular bacterial pathogen, could replicate within the unicellular organism Dictyostelium discoideum. By several criteria, L....
Fan, Zhenghong, Grantham, Michael L., Smith, M. Shane, Anderson, Eric S., Cardelli, James A., Muggeridge, Martin I.
Formation of small polykaryons by cell-cell fusion is characteristic of herpes simplex virus (HSV) lesions, but the great majority of viruses isolated from such lesions produce only limited cell...
RacB Regulates Cytoskeletal Function in Dictyostelium spp.
Lee, Eunkyung, Seastone, David J., Harris, Ed, Cardelli, James A., Knecht, David A.
Thus far, 14 homologues of mammalian Rac proteins have been identified in Dictyostelium. It is unclear whether each of these genes has a unique function or to what extent they play redundant roles in...
Bellaire, Bryan H, Roop, R. Martin, Cardelli, James A.
Cells in the Brucella spp. are intracellular pathogens that survive and replicate within host monocytes. Brucella maintains persistent infections in animals despite the production of high levels of...
Reed, Brent C., Cefalu, Christopher, Bellaire, Bryan H., Cardelli, James A., Louis, Thomas, Salamon, Joanna, ...
We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound...
Temesvari, Lesly, Zhang, Linyi, Fodera, Brent, Janssen, Klaus-Peter, Schleicher, Michael, Cardelli, James A.
Profilin is a key phosphoinositide and actin-binding protein connecting and coordinating changes in signal transduction pathways with alterations in the actin cytoskeleton. Using biochemical assays...
Solomon, Jonathan M., Rupper, Adam, Cardelli, James A., Isberg, Ralph R.
Conditions were established in which Legionella pneumophila, an intracellular bacterial pathogen, could replicate within the unicellular organism Dictyostelium discoideum. By several criteria, L....
Fan, Zhenghong, Grantham, Michael L., Smith, M. Shane, Anderson, Eric S., Cardelli, James A., Muggeridge, Martin I.
Formation of small polykaryons by cell-cell fusion is characteristic of herpes simplex virus (HSV) lesions, but the great majority of viruses isolated from such lesions produce only limited cell...
RacB Regulates Cytoskeletal Function in Dictyostelium spp.
Lee, Eunkyung, Seastone, David J., Harris, Ed, Cardelli, James A., Knecht, David A.
Thus far, 14 homologues of mammalian Rac proteins have been identified in Dictyostelium. It is unclear whether each of these genes has a unique function or to what extent they play redundant roles in...
Bellaire, Bryan H, Roop, R. Martin, Cardelli, James A.
Cells in the Brucella spp. are intracellular pathogens that survive and replicate within host monocytes. Brucella maintains persistent infections in animals despite the production of high levels of...
Reed, Brent C., Cefalu, Christopher, Bellaire, Bryan H., Cardelli, James A., Louis, Thomas, Salamon, Joanna, ...
We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound...
Rupper, Adam C., Cardelli, James A.
The regulation of caspase-1 activation in macrophages plays a central role in host defense against bacterial pathogens. The activation of caspase-1 by the detection of bacterial products through...
Snider, Jared L., Allison, Cody, Bellaire, Bryan H., Ferrero, Richard L., Cardelli, James A.
The Helicobacter pylori CagA protein is translocated into gastric epithelial cells through a type IV secretion system (TFSS), and published studies suggest CagA is critical for H. pylori-associated...