Coccidioides Immitis, Coccidioides Posadasii, James A. Fraser, Jason E. Stajich, Eric J. Tarcha, Garry T. Cole, ...
Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell...
Kavanaugh, Laura A., Fraser, James A., Dietrich, Fred S.
The availability of the whole-genome sequence from the 2 known varieties of the human pathogenic fungus Cryptococcus neoformans provides an opportunity to study the relative contribution of...
Kavanaugh, Laura A., Fraser, James A., Dietrich, Fred S.
The availability of the whole-genome sequence from the two known varieties of the human pathogenic fungus Cryptococcus neoformans provides an opportunity to study the relative contribution of...
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms (2004)
James A. Fraser, Stephanie Diezmann, Ryan L. Subaran, Andria Allen, Klaus B. Lengeler, Fred S. Dietrich, ...
A comparative genomic analysis of the sex determining region in fungi reveals a remarkable similarity between its evolution and the events which shaped mammalian sex chromosomes
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms (2004)
James A. Fraser, Stephanie Diezmann, Ryan L. Subaran, Andria Allen, Klaus B. Lengeler, Fred S. Dietrich, ...
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen...
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms (2004)
Fraser, James A., Diezmann, Stephanie, Subaran, Ryan L., Allen, Andria, Lengeler, Klaus B., Dietrich, Fred S., ...
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen...
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms (2004)
Fraser, James A., Diezmann, Stephanie, Subaran, Ryan L., Allen, Andria, Lengeler, Klaus B., Dietrich, Fred S., ...
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen...
Monahan, Brendon J., Fraser, James A., Hynes, Michael J., Davis, Meryl A.
Ammonium and the analogue methylammonium are taken into the cell by active transport systems which constitute a family of transmembrane proteins that have been identified in fungi, bacteria, plants,...
Fraser, James A., Davis, Meryl A., Hynes, Michael J.
Aspergillus nidulans is a saprophytic ascomycete that utilizes a wide variety of nitrogen sources. We identified a sequence from A. nidulans similar to the glutathione S-transferase-like nitrogen...
Mating-Type Locus of Cryptococcus neoformans: a Step in the Evolution of Sex Chromosomes
Lengeler, Klaus B., Fox, Deborah S., Fraser, James A., Allen, Andria, Forrester, Keri, Dietrich, Fred S., ...
The sexual development and virulence of the fungal pathogen Cryptococcus neoformans is controlled by a bipolar mating system determined by a single locus that exists in two alleles, α and a. The α...
Fraser, James A., Subaran, Ryan L., Nichols, Connie B., Heitman, Joseph
Cryptococcus neoformans is a human fungal pathogen that exists as three distinct varieties or sibling species: the predominantly opportunistic pathogens C. neoformans var. neoformans (serotype D) and...
Nichols, Connie B., Fraser, James A., Heitman, Joseph
Sexual identity and mating are linked to virulence of the fungal pathogen Cryptococcus neoformans. Cells of the α mating type are more prevalent and can be more virulent than a cells, and...
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
Fraser, James A, Diezmann, Stephanie, Subaran, Ryan L, Allen, Andria, Lengeler, Klaus B, Dietrich, Fred S, ...
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen...
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans†
Fraser, James A., Huang, Johnny C., Pukkila-Worley, Read, Alspaugh, J. Andrew, Mitchell, Thomas G., Heitman, Joseph
Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to...
Campbell, Leona T., Fraser, James A., Nichols, Connie B., Dietrich, Fred S., Carter, Dee, Heitman, Joseph
Cryptococcus gattii is a primary pathogenic yeast that causes disease in both animals and humans. It is closely related to Cryptococcus neoformans and diverged from a common ancestor ∼40 million...
Todd, Richard B., Fraser, James A., Wong, Koon Ho, Davis, Meryl A., Hynes, Michael J.
Both the availability and the quality of nutrients affect cellular functions by controlling gene activity. AreA, a member of the GATA family of transcription factors, globally activates expression of...
Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions
Fraser, James A, Rang, Catherine EJ, Usher-Smith, Juliet A, Huang, Christopher L-H
The influence of extracellular hypotonicity on the relationship between cell volume (Vc) and resting membrane potential (Em) was investigated in Rana temporaria skeletal muscle. Vc was measured by...
Fraser, James A, Huang, Christopher L-H
This paper quantifies recent experimental results through a general physical description of the mechanisms that might control two fundamental cellular parameters, resting potential (Em) and cell...
Fraser, James A, Middlebrook, Claire E, Usher-Smith, Juliet A, Schwiening, Christof J, Huang, Christopher L-H
The relationship between cell volume (Vc) and membrane potential (Em) in Rana temporaria striated muscle fibres was investigated under different conditions of intracellular acidification. Confocal...
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions
Ferenczi, Emily A, Fraser, James A, Chawla, Sangeeta, Skepper, Jeremy N, Schwiening, Christof J, Huang, Christopher L-H
This study investigated membrane transport mechanisms influencing relative changes in cell volume (V) and resting membrane potential (Em) following osmotic challenge in amphibian skeletal muscle...
Monahan, Brendon J., Fraser, James A., Hynes, Michael J., Davis, Meryl A.
Ammonium and the analogue methylammonium are taken into the cell by active transport systems which constitute a family of transmembrane proteins that have been identified in fungi, bacteria, plants,...
Fraser, James A., Davis, Meryl A., Hynes, Michael J.
Aspergillus nidulans is a saprophytic ascomycete that utilizes a wide variety of nitrogen sources. We identified a sequence from A. nidulans similar to the glutathione S-transferase-like nitrogen...
Mating-Type Locus of Cryptococcus neoformans: a Step in the Evolution of Sex Chromosomes
Lengeler, Klaus B., Fox, Deborah S., Fraser, James A., Allen, Andria, Forrester, Keri, Dietrich, Fred S., ...
The sexual development and virulence of the fungal pathogen Cryptococcus neoformans is controlled by a bipolar mating system determined by a single locus that exists in two alleles, α and a. The α...
Fraser, James A., Subaran, Ryan L., Nichols, Connie B., Heitman, Joseph
Cryptococcus neoformans is a human fungal pathogen that exists as three distinct varieties or sibling species: the predominantly opportunistic pathogens C. neoformans var. neoformans (serotype D) and...
Nichols, Connie B., Fraser, James A., Heitman, Joseph
Sexual identity and mating are linked to virulence of the fungal pathogen Cryptococcus neoformans. Cells of the α mating type are more prevalent and can be more virulent than a cells, and...
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
Fraser, James A, Diezmann, Stephanie, Subaran, Ryan L, Allen, Andria, Lengeler, Klaus B, Dietrich, Fred S, ...
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen...
Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans†
Fraser, James A., Huang, Johnny C., Pukkila-Worley, Read, Alspaugh, J. Andrew, Mitchell, Thomas G., Heitman, Joseph
Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to...
Campbell, Leona T., Fraser, James A., Nichols, Connie B., Dietrich, Fred S., Carter, Dee, Heitman, Joseph
Cryptococcus gattii is a primary pathogenic yeast that causes disease in both animals and humans. It is closely related to Cryptococcus neoformans and diverged from a common ancestor ∼40 million...
Todd, Richard B., Fraser, James A., Wong, Koon Ho, Davis, Meryl A., Hynes, Michael J.
Both the availability and the quality of nutrients affect cellular functions by controlling gene activity. AreA, a member of the GATA family of transcription factors, globally activates expression of...
Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions
Fraser, James A, Rang, Catherine EJ, Usher-Smith, Juliet A, Huang, Christopher L-H
The influence of extracellular hypotonicity on the relationship between cell volume (Vc) and resting membrane potential (Em) was investigated in Rana temporaria skeletal muscle. Vc was measured by...
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions
Ferenczi, Emily A, Fraser, James A, Chawla, Sangeeta, Skepper, Jeremy N, Schwiening, Christof J, Huang, Christopher L-H
This study investigated membrane transport mechanisms influencing relative changes in cell volume (V) and resting membrane potential (Em) following osmotic challenge in amphibian skeletal muscle...
Fraser, James A, Huang, Christopher L-H
This paper quantifies recent experimental results through a general physical description of the mechanisms that might control two fundamental cellular parameters, resting potential (Em) and cell...
Fraser, James A, Middlebrook, Claire E, Usher-Smith, Juliet A, Schwiening, Christof J, Huang, Christopher L-H
The relationship between cell volume (Vc) and membrane potential (Em) in Rana temporaria striated muscle fibres was investigated under different conditions of intracellular acidification. Confocal...
Sabir, Ian N., Fraser, James A., Killeen, Matthew J., Grace, Andrew A., Huang, Christopher L.-H.
The clinical effects of hypokalemia including action potential prolongation and arrhythmogenicity suppressible by lidocaine were reproduced in hypokalemic (3.0 mM K+) Langendorff-perfused murine...
The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle
Usher-Smith, Juliet A, Fraser, James A, Bailey, Peter S J, Griffin, Julian L, Huang, Christopher L-H
The combined effects of intracellular lactate and proton accumulation on cell volume, Vc, were investigated in resting Rana temporaria striated muscle fibres. Intracellular lactate and H+...
Fraser, James A., Stajich, Jason E., Tarcha, Eric J., Cole, Garry T., Inglis, Diane O., Sil, Anita, ...
Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell...
Upton, Arlo, Fraser, James A., Kidd, Sarah E., Bretz, Camille, Bartlett, Karen H., Heitman, Joseph, ...
We report a case of cryptococcosis due to C. gattii which appears to have been acquired in the Puget Sound region, Washington State. Genotyping confirmed identity to the predominant Vancouver Island...
Reply from James A. Fraser, Juliet A. Usher-Smith and Christopher L.-H. Huang
Fraser, James A, Usher-Smith, Juliet A, Huang, Christopher L-H
Sabir, Ian N., Fraser, James A., Cass, Thomas R., Grace, Andrew A., Huang, Christopher L.-H.
The clinically established proarrhythmic effect of bradycardia and antiarrhythmic effect of lidocaine (10 μM) were reproduced in hypokalaemic (3.0 mM K+) Langendorff-perfused murine hearts paced...
Hsueh, Yen-Ping, Fraser, James A., Heitman, Joseph
Sex is orchestrated by the mating-type locus (MAT) in fungi and by sex chromosomes in plants and animals. In fungi, two patterns of sexuality occur: bipolar with a single, typically biallelic sex...
Mehta, Arpan R., Huang, Christopher L.-H., Skepper, Jeremy N., Fraser, James A.
The membrane potential measured by intracellular electrodes, Em, is the sum of the transmembrane potential difference (E1) between inner and outer cell membrane surfaces and a smaller potential...