Xin, Mei, Small, Eric M., Sutherland, Lillian B., Qi, Xiaoxia, McAnally, John, Plato, Craig F., ...
Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells (SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator, myocardin, play...
Liu, Ning, Bezprozvannaya, Svetlana, Williams, Andrew H., Qi, Xiaoxia, Richardson, James A., Bassel-Duby, Rhonda, ...
MicroRNAs (miRNAs) modulate gene expression by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential roles in organ formation or function. miR-133a-1 and...
Regulation of hyaluronan expression during cervical ripening (2005)
Straach, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
In preparation for birth, the uterine cervix undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a fetus....
Herron, Bruce J., Rao, Cherie, Liu, Shanming, Laprade, Lisa, Richardson, James A., Olivieri, Emily, ...
We have identified waved 3 (wa3), a novel recessive mutation that causes abnormalities of the heart and skin. The cardiac defect results in a severe and rapidly progressive dilated cardiomyopathy. We...
Regulation of hyaluronan expression during cervical ripening (2004)
Grabbe, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
The uterine cervix, in preparation for birth, undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a...
Polybromo protein BAF180 functions in mammalian cardiac chamber maturation (2004)
Wang, Zhong, Zhai, Weiguo, Richardson, James A., Olson, Eric N., Meneses, Juanito J., Firpo, Meri T., ...
BAF and PBAF are two related mammalian chromatin remodeling complexes essential for gene expression and development. PBAF, but not BAF, is able to potentiate transcriptional activation in vitro...
Regulation of hyaluronan expression during cervical ripening (2004)
Grabbe, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
The uterine cervix, in preparation for birth, undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a...
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer (2001)
Charité, Jeroen, McFadden, David G., Merlo, Giorgio, Levi, Giovanni, Clouthier, David E., Yanagisawa, Masashi, ...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type (1998)
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
Shimomura, Iichiro, Hammer, Robert E., Richardson, James A., Ikemoto, Shinji, Bashmakov, Yuriy, Goldstein, Joseph L., ...
The breakdown of oxide films on aluminium in neutral corrosive environments [microform] / (1969)
Thesis--University of Manchester.
An investigation of the effects of selected agility drills on gross body movement time / (1968)
Thesis (M.A.)--East Tennessee State University, 1968.
Author's name on spine.
Lu, Jianrong, Webb, Robert, Richardson, James A., Olson, Eric N.
Skeletal muscle development is controlled by a family of muscle-specific basic helix–loop–helix (bHLH) transcription factors that activate muscle genes by binding E-boxes (CANNTG) as heterodimers...
Kamat, Amrita, Graves, Katherine H., Smith, Margaret E., Richardson, James A., Mendelson, Carole R.
In humans, aromatase P450 (product of CYP19 gene), which catalyzes conversion of C19 steroids to estrogens, is expressed in a number of tissues, including ovary, adipose, and syncytiotrophoblast of...
The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis
Lu, JianRong, Chang, Priscilla, Richardson, James A., Gan, Lin, Weiler, Hartmut, Olson, Eric N.
Formation of numerous internal organs involves reciprocal epithelial–mesenchymal signaling and subsequent patterning and growth of the organ primordium. Capsulin is a basic helix–loop–helix...
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
Zhang, Weiguo, Li, Jia-Ling, Hosaka, Masahiro, Janz, Roger, Shelton, John M., Albright, George M., ...
The calcineurin inhibitor cyclosporine A (CsA) has emerged as a major cause of secondary hypertension in humans, but the underlying pathogenetic mechanisms have remained enigmatic. Synapsins are a...
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
Frey, Norbert, Richardson, James A., Olson, Eric N.
The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fiber gene expression...
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice
Gupta, Praveena, Soyombo, Abigail A., Atashband, Armita, Wisniewski, Krystyna E., Shelton, John M., Richardson, James A., ...
PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty...
Abnormalities of the Genitourinary Tract in Female Mice Lacking GATA5
Molkentin, Jeffery D., Tymitz, Kevin M., Richardson, James A., Olson, Eric N.
Members of the GATA family of transcription factors play important roles in cell fate specification, differentiation, and morphogenesis during mammalian development. GATA5, the only one of the six...
FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors
Lu, Jian-rong, McKinsey, Timothy A., Xu, Hongtao, Wang, Da-zhi, Richardson, James A., Olson, Eric N.
Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed...
Correlation of Cecal Microflora of HLA-B27 Transgenic Rats with Inflammatory Bowel Disease
Onderdonk, Andrew B., Richardson, James A., Hammer, Robert E., Taurog, Joel D.
Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Wang, Da-Zhi, Li, Shijie, Hockemeyer, Dirk, Sutherland, Lillian, Wang, Zhigao, Schratt, Gerhard, ...
Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two...
Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, ...
GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function....
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li, Shijie, Wang, Da-Zhi, Wang, Zhigao, Richardson, James A., Olson, Eric N.
Formation of the vascular system requires differentiation and patterning of endothelial and smooth muscle cells (SMCs). Although much attention has focused on development of the vascular endothelial...
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Gupta, Praveena, Soyombo, Abigail A., Shelton, John M., Wilkofsky, Ian G., Wisniewski, Krystyna E., Richardson, James A., ...
The palmitoyl protein thioesterase-2 (PPT2) gene encodes a lysosomal thioesterase homologous to PPT1, which is the enzyme defective in the human disorder called infantile neuronal ceroid...
Kedzierski, Rafal M., Grayburn, Paul A., Kisanuki, Yaz Y., Williams, Clay S., Hammer, Robert E., Richardson, James A., ...
Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in...
Essential Role of STAT3 in Body Weight and Glucose Homeostasis
Cui, Yunxia, Huang, Lu, Elefteriou, Florent, Yang, Guoqing, Shelton, John M., Giles, Jerald E., ...
STAT3 is a ubiquitous transcription factor that is indispensable during early embryogenesis. To study the functions of STAT3 postnatally, we generated conditional STAT3-deficient mice. To that end,...
Yanagisawa, Hiromi, Hammer, Robert E., Richardson, James A., Emoto, Noriaki, Williams, S. Clay, Takeda, Shin-ichi, ...
Endothelin-converting enzyme-1 and -2 (ECE-1 and -2) are membrane-bound metalloproteases that can cleave biologically the inactive endothelin-1 (ET-1) precursor to form active ET-1 in vitro. We...
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
Passier, Robert, Zeng, Hong, Frey, Norbert, Naya, Francisco J., Nicol, Rebekka L., McKinsey, Timothy A., ...
Hypertrophic growth is an adaptive response of the heart to diverse pathological stimuli and is characterized by cardiomyocyte enlargement, sarcomere assembly, and activation of a fetal program of...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive programs of gene expression are controlled by variations in motor neuron...
Shimomura, Iichiro, Hammer, Robert E., Richardson, James A., Ikemoto, Shinji, Bashmakov, Yuriy, Goldstein, Joseph L., ...
Overexpression of the nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) in cultured 3T3-L1 preadipocytes was shown previously to promote adipocyte differentiation. Here,...
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
López-Rodríguez, Cristina, Antos, Christopher L., Shelton, John M., Richardson, James A., Lin, Fangming, Novobrantseva, Tatiana I., ...
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress,...
Salt-sensitive hypertension in endothelin-B receptor–deficient rats
Gariepy, Cheryl E., Ohuchi, Takashi, Williams, S. Clay, Richardson, James A., Yanagisawa, Masashi
The role of the endothelin-B receptor (ETB) in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo. Spotting lethal (sl) rats carry a naturally...
Marschang, Peter, Brich, Jochen, Weeber, Edwin J., Sweatt, J. David, Shelton, John M., Richardson, James A., ...
LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally...
Feulner, J. Amelia, Lu, Mingfang, Shelton, JohnM., Zhang, Mei, Richardson, James A., Munford, Robert S.
Acyloxyacyl hydrolase (AOAH) is an unusual but highly conserved lipase, previously described only in myeloid cells, that removes secondary fatty acyl chains from bacterial lipopolysaccharides (LPS)...
Blevins, Jon S., Revel, Andrew T., Caimano, Melissa J., Yang, Xiaofeng F., Richardson, James A., Hagman, Kayla E., ...
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick...
Chang, Shurong, McKinsey, Timothy A., Zhang, Chun Li, Richardson, James A., Hill, Joseph A., Olson, Eric N.
The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that...
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
Lee, Young, Naseem, R. Haris, Duplomb, Laurence, Park, Byung-Hyun, Garry, Daniel J., Richardson, James A., ...
The physiologic function of the progressive hyperleptinemia of diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues of congenitally unleptinized obese rodents is far...
Tamura, Naohisa, Doolittle, Lynda K., Hammer, Robert E., Shelton, John M., Richardson, James A., Garbers, David L.
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking...
Polybromo protein BAF180 functions in mammalian cardiac chamber maturation
Wang, Zhong, Zhai, Weiguo, Richardson, James A., Olson, Eric N., Meneses, Juanito J., Firpo, Meri T., ...
BAF and PBAF are two related mammalian chromatin remodeling complexes essential for gene expression and development. PBAF, but not BAF, is able to potentiate transcriptional activation in vitro...
Cao, Dongsun, Wang, Zhigao, Zhang, Chun-Li, Oh, Jiyeon, Xing, Weibing, Li, Shijie, ...
Differentiation of smooth muscle cells is accompanied by the transcriptional activation of an array of muscle-specific genes controlled by serum response factor (SRF). Myocardin is a cardiac and...
Li, Shijie, Czubryt, Michael P., McAnally, John, Bassel-Duby, Rhonda, Richardson, James A., Wiebel, Franziska F., ...
Serum response factor (SRF) controls the transcription of muscle genes by recruiting a variety of partner proteins, including members of the myocardin family of transcriptional coactivators. Mice...
Spencer, Jeffrey A., Hacker, Shelby L., Davis, Elaine C., Mecham, Robert P., Knutsen, Russ H., Li, Dean Y., ...
Fibulin (fbln)-5 is an elastin-binding protein required for assembly and organization of elastic fibers. To examine the potential role of fbln-5 in vascular remodeling and neointima formation, we...
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain
Kelly, Michele A., Beuckmann, Carsten T., Williams, S. Clay, Sinton, Christopher M., Motoike, Toshiyuki, Richardson, James A., ...
Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
Nakagawa, Osamu, Arnold, Michael, Nakagawa, Masayo, Hamada, Hideaki, Shelton, John M., Kusano, Hajime, ...
Myocyte enhancer factor 2 (MEF2) plays essential roles in transcriptional control of muscle development. However, signaling pathways acting downstream of MEF2 are largely unknown. Here, we performed...
Chugh, Priti, Matta, Hittu, Schamus, Sandra, Zachariah, Sunny, Kumar, Arvind, Richardson, James A., ...
Human herpesvirus 8 (HHV-8, also called Kaposi's sarcoma-associated herpes virus) has been linked to Kaposi's sarcoma and primary effusion lymphoma. HHV-8-encoded viral Fas-associated death...
Pieper, Andrew A., Wu, Xinle, Han, Tina W., Estill, Sandi Jo, Dang, Quyen, Wu, Leeju C., ...
The neuronal PAS domain protein 3 (NPAS3) gene encoding a brain-enriched transcription factor was recently found to be disrupted in a family suffering from schizophrenia. Mice harboring compound...
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer
Charité, Jeroen, McFadden, David G., Merlo, Giorgio, Levi, Giovanni, Clouthier, David E., Yanagisawa, Masashi, ...
Neural crest cells play a key role in craniofacial development. The endothelin family of secreted polypeptides regulates development of several neural crest sublineages, including the branchial arch...
Oh, Jiyeon, Richardson, James A., Olson, Eric N.
Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the...
Davis, Christopher A., Haberland, Michael, Arnold, Michael A., Sutherland, Lillian B., McDonald, Oliver G., Richardson, James A., ...
Smooth muscle cells (SMCs) display remarkable phenotypic diversity and plasticity and can readily switch between proliferative and differentiated states in response to extracellular cues. In an...
Regulation of Cardiac Stress Signaling by Protein Kinase D1
Harrison, Brooke C., Kim, Mi-Sung, Van Rooij, Eva, Plato, Craig F., Papst, Philip J., Vega, Rick B., ...
In response to pathological stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is associated with myocyte hypertrophy, myocyte death, and fibrosis....
Engelking, Luke J., Evers, Bret M., Richardson, James A., Goldstein, Joseph L., Brown, Michael S., Liang, Guosheng
Insig-1 and Insig-2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG-CoA reductase. Here,...
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, Takeshi, Moschetta, Antonio, Lee, Youn-Kyoung, Peng, Li, Zhao, Guixiang, Downes, Michael, ...
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic...
Li, Shijie, Chang, Shurong, Qi, Xiaoxia, Richardson, James A., Olson, Eric N.
The mammary gland consists of a branched ductal system comprised of milk-producing epithelial cells that form ductile tubules surrounded by a myoepithelial cell layer that provides contractility...
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, Koichiro, Wang, Yanggan, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Hill, Joseph A., ...
The heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death. Calcium-dependent signaling pathways promote...
Lu, Jianrong, Webb, Robert, Richardson, James A., Olson, Eric N.
Skeletal muscle development is controlled by a family of muscle-specific basic helix–loop–helix (bHLH) transcription factors that activate muscle genes by binding E-boxes (CANNTG) as heterodimers...
Kamat, Amrita, Graves, Katherine H., Smith, Margaret E., Richardson, James A., Mendelson, Carole R.
In humans, aromatase P450 (product of CYP19 gene), which catalyzes conversion of C19 steroids to estrogens, is expressed in a number of tissues, including ovary, adipose, and syncytiotrophoblast of...
The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis
Lu, JianRong, Chang, Priscilla, Richardson, James A., Gan, Lin, Weiler, Hartmut, Olson, Eric N.
Formation of numerous internal organs involves reciprocal epithelial–mesenchymal signaling and subsequent patterning and growth of the organ primordium. Capsulin is a basic helix–loop–helix...
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
Zhang, Weiguo, Li, Jia-Ling, Hosaka, Masahiro, Janz, Roger, Shelton, John M., Albright, George M., ...
The calcineurin inhibitor cyclosporine A (CsA) has emerged as a major cause of secondary hypertension in humans, but the underlying pathogenetic mechanisms have remained enigmatic. Synapsins are a...
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
Frey, Norbert, Richardson, James A., Olson, Eric N.
The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fiber gene expression...
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice
Gupta, Praveena, Soyombo, Abigail A., Atashband, Armita, Wisniewski, Krystyna E., Shelton, John M., Richardson, James A., ...
PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty...
Abnormalities of the Genitourinary Tract in Female Mice Lacking GATA5
Molkentin, Jeffery D., Tymitz, Kevin M., Richardson, James A., Olson, Eric N.
Members of the GATA family of transcription factors play important roles in cell fate specification, differentiation, and morphogenesis during mammalian development. GATA5, the only one of the six...
FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors
Lu, Jian-rong, McKinsey, Timothy A., Xu, Hongtao, Wang, Da-zhi, Richardson, James A., Olson, Eric N.
Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed...
Correlation of Cecal Microflora of HLA-B27 Transgenic Rats with Inflammatory Bowel Disease
Onderdonk, Andrew B., Richardson, James A., Hammer, Robert E., Taurog, Joel D.
Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Wang, Da-Zhi, Li, Shijie, Hockemeyer, Dirk, Sutherland, Lillian, Wang, Zhigao, Schratt, Gerhard, ...
Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two...
Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, ...
GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function....
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li, Shijie, Wang, Da-Zhi, Wang, Zhigao, Richardson, James A., Olson, Eric N.
Formation of the vascular system requires differentiation and patterning of endothelial and smooth muscle cells (SMCs). Although much attention has focused on development of the vascular endothelial...
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Gupta, Praveena, Soyombo, Abigail A., Shelton, John M., Wilkofsky, Ian G., Wisniewski, Krystyna E., Richardson, James A., ...
The palmitoyl protein thioesterase-2 (PPT2) gene encodes a lysosomal thioesterase homologous to PPT1, which is the enzyme defective in the human disorder called infantile neuronal ceroid...
Kedzierski, Rafal M., Grayburn, Paul A., Kisanuki, Yaz Y., Williams, Clay S., Hammer, Robert E., Richardson, James A., ...
Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in...
Essential Role of STAT3 in Body Weight and Glucose Homeostasis
Cui, Yunxia, Huang, Lu, Elefteriou, Florent, Yang, Guoqing, Shelton, John M., Giles, Jerald E., ...
STAT3 is a ubiquitous transcription factor that is indispensable during early embryogenesis. To study the functions of STAT3 postnatally, we generated conditional STAT3-deficient mice. To that end,...
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer
Charité, Jeroen, McFadden, David G., Merlo, Giorgio, Levi, Giovanni, Clouthier, David E., Yanagisawa, Masashi, ...
Neural crest cells play a key role in craniofacial development. The endothelin family of secreted polypeptides regulates development of several neural crest sublineages, including the branchial arch...
Yanagisawa, Hiromi, Hammer, Robert E., Richardson, James A., Emoto, Noriaki, Williams, S. Clay, Takeda, Shin-ichi, ...
Endothelin-converting enzyme-1 and -2 (ECE-1 and -2) are membrane-bound metalloproteases that can cleave biologically the inactive endothelin-1 (ET-1) precursor to form active ET-1 in vitro. We...
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
Passier, Robert, Zeng, Hong, Frey, Norbert, Naya, Francisco J., Nicol, Rebekka L., McKinsey, Timothy A., ...
Hypertrophic growth is an adaptive response of the heart to diverse pathological stimuli and is characterized by cardiomyocyte enlargement, sarcomere assembly, and activation of a fetal program of...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive programs of gene expression are controlled by variations in motor neuron...
Shimomura, Iichiro, Hammer, Robert E., Richardson, James A., Ikemoto, Shinji, Bashmakov, Yuriy, Goldstein, Joseph L., ...
Overexpression of the nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) in cultured 3T3-L1 preadipocytes was shown previously to promote adipocyte differentiation. Here,...
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
López-Rodríguez, Cristina, Antos, Christopher L., Shelton, John M., Richardson, James A., Lin, Fangming, Novobrantseva, Tatiana I., ...
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress,...
Salt-sensitive hypertension in endothelin-B receptor–deficient rats
Gariepy, Cheryl E., Ohuchi, Takashi, Williams, S. Clay, Richardson, James A., Yanagisawa, Masashi
The role of the endothelin-B receptor (ETB) in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo. Spotting lethal (sl) rats carry a naturally...
Marschang, Peter, Brich, Jochen, Weeber, Edwin J., Sweatt, J. David, Shelton, John M., Richardson, James A., ...
LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally...
Feulner, J. Amelia, Lu, Mingfang, Shelton, JohnM., Zhang, Mei, Richardson, James A., Munford, Robert S.
Acyloxyacyl hydrolase (AOAH) is an unusual but highly conserved lipase, previously described only in myeloid cells, that removes secondary fatty acyl chains from bacterial lipopolysaccharides (LPS)...
Blevins, Jon S., Revel, Andrew T., Caimano, Melissa J., Yang, Xiaofeng F., Richardson, James A., Hagman, Kayla E., ...
luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick...
Chang, Shurong, McKinsey, Timothy A., Zhang, Chun Li, Richardson, James A., Hill, Joseph A., Olson, Eric N.
The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that...
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
Lee, Young, Naseem, R. Haris, Duplomb, Laurence, Park, Byung-Hyun, Garry, Daniel J., Richardson, James A., ...
The physiologic function of the progressive hyperleptinemia of diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues of congenitally unleptinized obese rodents is far...
Tamura, Naohisa, Doolittle, Lynda K., Hammer, Robert E., Shelton, John M., Richardson, James A., Garbers, David L.
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking...
Polybromo protein BAF180 functions in mammalian cardiac chamber maturation
Wang, Zhong, Zhai, Weiguo, Richardson, James A., Olson, Eric N., Meneses, Juanito J., Firpo, Meri T., ...
BAF and PBAF are two related mammalian chromatin remodeling complexes essential for gene expression and development. PBAF, but not BAF, is able to potentiate transcriptional activation in vitro...
Cao, Dongsun, Wang, Zhigao, Zhang, Chun-Li, Oh, Jiyeon, Xing, Weibing, Li, Shijie, ...
Differentiation of smooth muscle cells is accompanied by the transcriptional activation of an array of muscle-specific genes controlled by serum response factor (SRF). Myocardin is a cardiac and...
Li, Shijie, Czubryt, Michael P., McAnally, John, Bassel-Duby, Rhonda, Richardson, James A., Wiebel, Franziska F., ...
Serum response factor (SRF) controls the transcription of muscle genes by recruiting a variety of partner proteins, including members of the myocardin family of transcriptional coactivators. Mice...
Spencer, Jeffrey A., Hacker, Shelby L., Davis, Elaine C., Mecham, Robert P., Knutsen, Russ H., Li, Dean Y., ...
Fibulin (fbln)-5 is an elastin-binding protein required for assembly and organization of elastic fibers. To examine the potential role of fbln-5 in vascular remodeling and neointima formation, we...
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain
Kelly, Michele A., Beuckmann, Carsten T., Williams, S. Clay, Sinton, Christopher M., Motoike, Toshiyuki, Richardson, James A., ...
Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
Nakagawa, Osamu, Arnold, Michael, Nakagawa, Masayo, Hamada, Hideaki, Shelton, John M., Kusano, Hajime, ...
Myocyte enhancer factor 2 (MEF2) plays essential roles in transcriptional control of muscle development. However, signaling pathways acting downstream of MEF2 are largely unknown. Here, we performed...
Chugh, Priti, Matta, Hittu, Schamus, Sandra, Zachariah, Sunny, Kumar, Arvind, Richardson, James A., ...
Human herpesvirus 8 (HHV-8, also called Kaposi's sarcoma-associated herpes virus) has been linked to Kaposi's sarcoma and primary effusion lymphoma. HHV-8-encoded viral Fas-associated death...
Pieper, Andrew A., Wu, Xinle, Han, Tina W., Estill, Sandi Jo, Dang, Quyen, Wu, Leeju C., ...
The neuronal PAS domain protein 3 (NPAS3) gene encoding a brain-enriched transcription factor was recently found to be disrupted in a family suffering from schizophrenia. Mice harboring compound...
Oh, Jiyeon, Richardson, James A., Olson, Eric N.
Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the...
Davis, Christopher A., Haberland, Michael, Arnold, Michael A., Sutherland, Lillian B., McDonald, Oliver G., Richardson, James A., ...
Smooth muscle cells (SMCs) display remarkable phenotypic diversity and plasticity and can readily switch between proliferative and differentiated states in response to extracellular cues. In an...
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, Takeshi, Moschetta, Antonio, Lee, Youn-Kyoung, Peng, Li, Zhao, Guixiang, Downes, Michael, ...
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic...
Regulation of Cardiac Stress Signaling by Protein Kinase D1
Harrison, Brooke C., Kim, Mi-Sung, Van Rooij, Eva, Plato, Craig F., Papst, Philip J., Vega, Rick B., ...
In response to pathological stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is associated with myocyte hypertrophy, myocyte death, and fibrosis....
Engelking, Luke J., Evers, Bret M., Richardson, James A., Goldstein, Joseph L., Brown, Michael S., Liang, Guosheng
Insig-1 and Insig-2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG-CoA reductase. Here,...
Li, Shijie, Chang, Shurong, Qi, Xiaoxia, Richardson, James A., Olson, Eric N.
The mammary gland consists of a branched ductal system comprised of milk-producing epithelial cells that form ductile tubules surrounded by a myoepithelial cell layer that provides contractility...
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, Koichiro, Wang, Yanggan, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Hill, Joseph A., ...
The heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death. Calcium-dependent signaling pathways promote...
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development
Guénette, Suzanne, Chang, Yang, Hiesberger, Thomas, Richardson, James A, Eckman, Christopher B, Eckman, Elizabeth A, ...
Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia. Heterotopias resembling those found in cobblestone lissencephalies in which...
A threshold of GATA4 and GATA6 expression is required for cardiovascular development
Xin, Mei, Davis, Christopher A., Molkentin, Jeffery D., Lien, Ching-Ling, Duncan, Stephen A., Richardson, James A., ...
The zinc-finger transcription factors GATA4 and GATA6 play critical roles in embryonic development. Mouse embryos lacking GATA4 die at embryonic day (E) 8.5 because of failure of ventral foregut...
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
Mieda, Michihiro, Williams, S. Clay, Richardson, James A., Tanaka, Kohichi, Yanagisawa, Masashi
Temporal restriction of feeding can phase-shift behavioral and physiological circadian rhythms in mammals. These changes in biological rhythms are postulated to be brought about by a food-entrainable...
Human Plasma and the Antibacterial Effect of Peritoneal Dialysis Solutions
Borchardt, Kenneth A., Richardson, James A.
The influence of human plasma on the antibacterial effect of solutions for peritoneal dialysis was studied. The solutions contained 43 mEq per litre of either acetate or lactate as the source of...
Introduction and synthesis: Plant phylogeny and the origin of major biomes.
Pennington, R Toby, Cronk, Quentin C B, Richardson, James A
Phylogenetic trees based upon DNA sequence data, when calibrated with a dimension of time, allow inference of: (i) the pattern of accumulation of lineages through time; (ii) the time of origin of...
Ivanov, Sergey V., Ward, Jerrold M., Tessarollo, Lino, McAreavey, Dorothea, Sachdev, Vandana, Fananapazir, Lameh, ...
CACNA2D2 is a putative tumor suppressor gene located in the human chromosome 3p21.3 region that shows frequent allelic imbalances in lung, breast, and other cancers. The α2δ-2 protein encoded by...
Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
Kuwahara, Koichiro, Pipes, Gordon C. Teg, McAnally, John, Richardson, James A., Hill, Joseph A., Bassel-Duby, Rhonda, ...
Cytoskeletal proteins have been implicated in the pathogenesis of cardiomyopathy, but how the cytoskeleton influences the transcriptional alterations associated with adverse cardiac remodeling...
Van Rooij, Eva, Sutherland, Lillian B., Liu, Ning, Williams, Andrew H., McAnally, John, Gerard, Robert D., ...
Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of...
Molecular Analysis of Fibulin-5 Function during De Novo Synthesis of Elastic Fibers▿
Zheng, Qian, Davis, Elaine C., Richardson, James A., Starcher, Barry C., Li, Tiansen, Gerard, Robert D., ...
Elastic fibers contribute to the structural support of tissues and to the regulation of cellular behavior. Mice deficient for the fibulin-5 gene (fbln5−/−) were used to further elucidate the...
Molecular Analysis of Fibulin-5 Function during De Novo Synthesis of Elastic Fibers
Zheng, Qian, Davis, Elaine C., Richardson, James A., Starcher, Barry C., Li, Tiansen, Gerard, Robert D., ...
Cardiac autophagy is a maladaptive response to hemodynamic stress
Zhu, Hongxin, Tannous, Paul, Johnstone, Janet L., Kong, Yongli, Shelton, John M., Richardson, James A., ...
Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms governing the transition from stable cardiac...
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
Potthoff, Matthew J., Wu, Hai, Arnold, Michael A., Shelton, John M., Backs, Johannes, McAnally, John, ...
Skeletal muscle is composed of heterogeneous myofibers with distinctive rates of contraction, metabolic properties, and susceptibility to fatigue. We show that class II histone deacetylase (HDAC)...
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3
Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Latif, Shuaib, Spencer, Jeffrey A., Glass, David J., ...
Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere. Abnormalities in...
Fielitz, Jens, Van Rooij, Eva, Spencer, Jeffrey A., Shelton, John M., Latif, Shuaib, Van Der Nagel, Roel, ...
RING-finger proteins commonly function as ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome pathway. Muscle-specific RING-finger (MuRF) proteins are striated...
Adverse Effect on Bacteria of Peritoneal Dialysis Solutions that Contain Acetate*
Richardson, James A., Borchardt, Kenneth A.
Peritoneal dialysis solutions which contained 43 mEq per litre of acetate had a greater antibacterial effect than those containing lactate. Bacteria were isolated from 15 separate clinical...
Xin, Mei, Small, Eric M., Van Rooij, Eva, Qi, Xiaoxia, Richardson, James A., Srivastava, Deepak, ...
The basic helix–loop–helix transcriptional repressor Hairy-related transcription factor 2 (Hrt2) is expressed in ventricular, but not atrial, cardiomyocytes, and in endothelial and vascular...
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
Montgomery, Rusty L., Davis, Christopher A., Potthoff, Matthew J., Haberland, Michael, Fielitz, Jens, Qi, Xiaoxia, ...
Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from histone tails. The class I HDACs, HDAC1 and HDAC2, are expressed...
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice
Kim, Yuri, Phan, Dillon, Van Rooij, Eva, Wang, Da-Zhi, McAnally, John, Qi, Xiaoxia, ...
The adult heart responds to excessive neurohumoral signaling and workload by a pathological growth response characterized by hypertrophy of cardiomyocytes and activation of a fetal program of cardiac...
Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c▿
Potthoff, Matthew J., Arnold, Michael A., McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Myocyte enhancer factor 2 (MEF2) transcription factors cooperate with the MyoD family of basic helix-loop-helix (bHLH) transcription factors to drive skeletal muscle development during embryogenesis,...
Shi, Xiaoyan, Xie, Chun, Kreska, Desi, Richardson, James A., Mohan, Chandra
Genetic dissection of lupus pathogenesis in the NZM2410 strain has recently revealed that Sle1 is a potent locus that triggers the formation of IgG anti-histone/DNA antibodies, when expressed on the...
Zhou, Ming, Sayad, Alain, Simmons, William A., Jones, Richard C., Maika, Shanna D., Satumtira, Nimman, ...
Human histocompatibility leukocyte antigen B27 is highly associated with the rheumatic diseases termed spondyloarthropathies, but the mechanism is not known. B27 transgenic rats develop a spontaneous...
Subjective evaluation of composite econometric policy inputs
Gulledge, Thomas Jr., Ringuest, Jeffrey L., Richardson, James A.
Spencer, Jeffrey A., Eliazer, Susan, Ilaria, Robert L., Richardson, James A., Olson, Eric N.
The RING-finger domain is a novel zinc-binding Cys-His protein motif found in a growing number of proteins involved in signal transduction, ubiquitination, gene transcription, differentiation, and...
Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
Rybkin, Igor I., Kim, Mi-Sung, Bezprozvannaya, Svetlana, Qi, Xiaoxia, Richardson, James A., Plato, Craig F., ...
Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins,...
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
Liu, Ning, Williams, Andrew H., Kim, Yuri, McAnally, John, Bezprozvannaya, Svetlana, Sutherland, Lillian B., ...
The muscle-specific microRNAs, miR-1 and miR-133, play important roles in muscle growth and differentiation. Here, we show that the MEF2 transcription factor, an essential regulator of muscle...
Requirement of protein kinase D1 for pathological cardiac remodeling
Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Qi, Xiaoxia, Hill, Joseph A., Richardson, James A., ...
The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class...
Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance▿
Kim, Mi-Sung, Fielitz, Jens, McAnally, John, Shelton, John M., Lemon, Douglas D., McKinsey, Timothy A., ...
Skeletal muscle consists of type I and type II myofibers, which exhibit different metabolic and contractile properties. Type I fibers display an oxidative metabolism and are resistant to fatigue,...
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
Montgomery, Rusty L., Potthoff, Matthew J., Haberland, Michael, Qi, Xiaoxia, Matsuzaki, Satoshi, Humphries, Kenneth M., ...
Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety of disorders, including cancer, neurological disease, and cardiac hypertrophy. However, the specific HDAC...
Barbosa, Ana C., Kim, Mi-Sung, Ertunc, Mert, Adachi, Megumi, Nelson, Erika D., McAnally, John, ...
Learning and memory depend on the activity-dependent structural plasticity of synapses and changes in neuronal gene expression. We show that deletion of the MEF2C transcription factor in the CNS of...
Lavery, Gareth G., Walker, Elizabeth A., Turan, Nil, Rogoff, Daniela, Ryder, Jeffery W., Shelton, John M., ...
Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver H6PD is required...
Liu, Ning, Bezprozvannaya, Svetlana, Williams, Andrew H., Qi, Xiaoxia, Richardson, James A., Bassel-Duby, Rhonda, ...
MicroRNAs (miRNAs) modulate gene expression by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential roles in organ formation or function. miR-133a-1 and...
Ferdous, Anwarul, Caprioli, Arianna, Iacovino, Michelina, Martin, Cindy M., Morris, Jesse, Richardson, James A., ...
Recent studies support the existence of a common progenitor for the cardiac and endothelial cell lineages, but the underlying transcriptional networks responsible for specification of these cell...
Backs, Johannes, Backs, Thea, Neef, Stefan, Kreusser, Michael M., Lehmann, Lorenz H., Patrick, David M., ...
Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein...
Montgomery, Rusty L., Hsieh, Jenny, Barbosa, Ana C., Richardson, James A., Olson, Eric N.
The molecular mechanism by which neural progenitor cells commit to a specified lineage of the central nervous system remains unknown. We show that HDAC1 and HDAC2 redundantly control neuronal...