Christopher D. Dharmaraj, Kishan Thadikonda, Anthony R. Fletcher, Phuc N. Doan, Nallathamby Devasahayam, Shingo Matsumoto, ...
Three-dimensional Oximetric Electron Paramagnetic Resonance Imaging using the Single Point Imaging modality generates unpaired spin density and oxygen images that can readily distinguish between...
Christopher D. Dharmaraj, Kishan Thadikonda, Anthony R. Fletcher, Phuc N. Doan, Nallathamby Devasahayam, Shingo Matsumoto, ...
Three-dimensional Oximetric Electron Paramagnetic Resonance Imaging using the Single Point Imaging modality generates unpaired spin density and oxygen images that can readily distinguish between...
Abstract Electron Paramagnetic Resonance for Small Animal Imaging Applications (2008)
Murali C. Krishna, Nallathamby Devasahayam, John A. Cook, Sankaran Subramanian, James B. Mitchell
Magnetic resonance imaging (MRI) provides high-resolution morphological images useful in diagnostic radiology to differentiate between normal and abnormal/pathological states in tissues. More...
Thierry M. Muanza, Ana P. Cotrim, Mathew Mcauliffe, Anastasia L. Sowers, Bruce J. Baum, John A. Cook, ...
Abstract Purpose: Optical coherence tomography (OCT) imaging was evaluated to determine if radiationinduced mucosal damage could be noninvasively monitored in real time and correlated with...
Nmr Biomed, Published Wiley, Sankaran Subramanian, Ken-ichiro Matsumoto, James B. Mitchell, Murali C. Krishna
Radio frequency continuous-wave and time-domain EPR imaging and Overhauser-enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for...
Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study (2007)
Simone, Nicole L, Soule, Benjamin P, Gerber, Lynn, Augustine, Elizabeth, Smith, Sharon, Altemus, Rosemary M, ...
Abstract Background Fibrosis is a common side effect after treatment with ionizing radiation. Several methods to ameliorate debilitating fibrosis have been employed but without consistent results....
Chan, Linda W, Hapdey, Sebastien, English, Sean, Seidel, Jurgen, Carson, Joann, Sowers, Anastasia L, ...
Abstract Background This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of 18 F-FDG (fluorine-18 deoxyglucose), a marker for glucose...
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor (2005)
Erker, Laura, Schubert, Ralf, Yakushiji, Hiroyuki, Barlow, Carrolee, Larson, Denise, Mitchell, James B., ...
We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of...
Popular Autobiography as Historiography: The Reality Effect of Frank McCourt's Angela's Ashes (2004)
Biography - Volume 26, Number 4, Fall 2003
and Tumor Suppressors (791 articles) (2004)
Andreas Rosenwald, Eric Y. Chuang, R. Eric Davis, Adrian Wiestner, Ash A. Alizadeh, Diane C, ...
doi:10.1182/blood-2003-09-3236 Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
C. Norman Coleman, William F. Blakely, John R. Fike, Thomas J. MacVittie, Noelle F. Metting, James B. Mitchell, ...
Coleman, C. N., Blakely, W. F., Fike, J. R., MacVittie, T. J., Metting, N. F., Mitchell, J. B., Moulder, J. E., Preston, R. J., Seed, T. M., Stone, H. B., Tofilon, P. J. and Wong, R. S. L. Molecular...
An application system for automation of constant-time radio frequency electron paramagnetic (2002)
Andrew G. Taube, Sankaran Subramanian, Ran Murugesan, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, ...
resonance imaging
Radiation Sensitization of Mammalian Cells by Metal Chelators (2001)
Yuval Samuni, William DeGraff, Mordechai Chevion, James B. Mitchell, John A. Cook
Samuni, Y., DeGraff, W., Chevion, M., Mitchell, J. B. and Cook, J. A. Radiation Sensitization of Mammalian Cells by Metal Chelators. The cell cycle effects, alteration in radiation response, and...
Gimble, Thomas F., Brannin, Patricia A., West, Robert K., Mitchell, James B., Blalock, Carolyn M.
This audit was performed in response to a DoD Hotline referral. The overall allegation was that Air Force officers working on special access and other highly classified programs were at a...
In Vitro Studies of Taxol as a Radiation Sensitizer in Human Tumor Cells (1994)
Liebmann, James, Cook, John A., Fisher, Joyce, Teague, Diane, Mitchell, James B.
Background: Cells exposed to paclitaxel (Taxol) develop a cell cycle arrest in G2/M. It has long been recognized that late G2 and M are the most radiosensitive phases of the cell cycle. Purpose:...
Fornace, Albert J., Mitchell, James B.
When hybridization subtraction was used to enrich for sequences induced by heat shock in Chinese hamster cells, B2 sequences were found to be one of the major sequences enriched. With cloned B2...
Typescript (photocopy)
Krishna, Murali C., English, Sean, Yamada, Kenichi, Yoo, John, Murugesan, Ramachandran, Devasahayam, Nallathamby, ...
An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on...
Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak
Chandrasekharan, Subhashini, Qiu, Ting Hu, Alkharouf, Nawal, Brantley, Kelly, Mitchell, James B., Liu, Edison T.
Frk/rak belongs to a novel family of Src kinases with epithelial tissue-specific expression. Although developmental expression patterns and functional overexpression in vitro have associated these...
Samuni, Ayelet M., Chuang, Eric Y., Krishna, Murali C., Stein, William, DeGraff, William, Russo, Angelo, ...
Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE2), an oxidative metabolite of estrogen, by antioxidants was assessed in human MCF7 cells and TK-6 lymphoblast cells. The...
Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., ...
Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether...
Chan, Linda W, Hapdey, Sebastien, English, Sean, Seidel, Jurgen, Carson, Joann, Sowers, Anastasia L, ...
Krishna, Murali C., English, Sean, Yamada, Kenichi, Yoo, John, Murugesan, Ramachandran, Devasahayam, Nallathamby, ...
An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on...
Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak
Chandrasekharan, Subhashini, Qiu, Ting Hu, Alkharouf, Nawal, Brantley, Kelly, Mitchell, James B., Liu, Edison T.
Frk/rak belongs to a novel family of Src kinases with epithelial tissue-specific expression. Although developmental expression patterns and functional overexpression in vitro have associated these...
Samuni, Ayelet M., Chuang, Eric Y., Krishna, Murali C., Stein, William, DeGraff, William, Russo, Angelo, ...
Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE2), an oxidative metabolite of estrogen, by antioxidants was assessed in human MCF7 cells and TK-6 lymphoblast cells. The...
Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., ...
Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether...
Chan, Linda W, Hapdey, Sebastien, English, Sean, Seidel, Jurgen, Carson, Joann, Sowers, Anastasia L, ...
Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study
Simone, Nicole L, Soule, Benjamin P, Gerber, Lynn, Augustine, Elizabeth, Smith, Sharon, Altemus, Rosemary M, ...
Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation
Flanders, Kathleen C., Sullivan, Catherine D., Fujii, Makiko, Sowers, Anastasia, Anzano, Mario A., Arabshahi, Alidad, ...
Transforming growth factor-β (TGF-β) plays a central role in the pathogenesis of inflammatory and fibrotic diseases, including radiation-induced fibrosis. We previously reported that mice null for...
Flanders, Kathleen C., Major, Christopher D., Arabshahi, Alidad, Aburime, Ekinadese E., Okada, Miya H., Fujii, Makiko, ...
Transforming growth factor (TGF)-β regulates many aspects of wound repair including inflammation, chemotaxis, and deposition of extracellular matrix. We previously showed that epithelialization of...
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice
Matsumoto, Shingo, Hyodo, Fuminori, Subramanian, Sankaran, Devasahayam, Nallathamby, Munasinghe, Jeeva, Hyodo, Emi, ...
A priori knowledge of spatial and temporal changes in partial pressure of oxygen (oxygenation; pO2) in solid tumors, a key prognostic factor in cancer treatment outcome, could greatly improve...
Flanders, Kathleen C., Ho, Benjamin M., Arany, Praveen R., Stuelten, Christina, Mamura, Mizuko, Paterniti, Miya Okada, ...
Our previous work showed that 6 weeks after cutaneous irradiation, mice null (knockout, KO) for Smad3, a cytoplasmic downstream mediator of transforming growth factor-β, demonstrate less epidermal...
Ghosh, Manik C., Tong, Wing-Hang, Zhang, Deliang, Ollivierre-Wilson, Hayden, Singh, Anamika, Krishna, Murali C., ...
In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron...
Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression
Simone, Nicole L., Soule, Benjamin P., Ly, David, Saleh, Anthony D., Savage, Jason E., DeGraff, William, ...
Dharmaraj, Christopher D., Thadikonda, Kishan, Fletcher, Anthony R., Doan, Phuc N., Devasahayam, Nallathamby, Matsumoto, Shingo, ...
Three-dimensional Oximetric Electron Paramagnetic Resonance Imaging using the Single Point Imaging modality generates unpaired spin density and oxygen images that can readily distinguish between...
Matsumoto, Shingo, Yasui, Hironobu, Batra, Sonny, Kinoshita, Yuichi, Bernardo, Marcelino, Munasinghe, Jeeva P., ...
Architectural and functional abnormalities of blood vessels are a common feature in tumors. A consequence of increased vascular permeability and concomitant aberrant blood flow is poor delivery of...