James C. Paton

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea (2005)

Paton, Adrienne W., Jennings, Michael P., Morona, Renato, Wang, Hui, Focareta, Antonio, Roddam, Louise F., ...

Background & Aims: We have developed a therapeutic strategy for gastrointestinal infections that is based on molecular mimicry of host receptors for bacterial toxins on the surface of harmless gut...

Modulation of Adherence, Invasion, and Tumor Necrosis Factor Alpha Secretion during the Early Stages of Infection by Streptococcus pneumoniae ClpL▿

Tu, Le Nhat, Jeong, Hye-Yoon, Kwon, Hyog-Young, Ogunniyi, Abiodun D., Paton, James C., Pyo, Suhk-Neung, ...

Heat shock proteins (HSPs) play a pivotal role as chaperones in the folding of native and denatured proteins and can help pathogens penetrate host defenses. However, the underlying mechanism(s) of...

The Pneumococcal Two-Component Signal Transduction System RR/HK06 Regulates CbpA and PspA by Two Distinct Mechanisms▿

Standish, Alistair J., Stroeher, Uwe H., Paton, James C.

We have previously shown that CbpA, a major pneumococcal virulence factor, is regulated by the two-component signal transduction system RR/HK06 (A. J. Standish, U. H. Stroeher, and J. C. Paton, Proc....

Correction

Paton, Adrienne W., Srimanote, Potjanee, Talbot, Ursula M., Wang, Hui, Paton, James C.

A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli

Paton, Adrienne W., Srimanote, Potjanee, Talbot, Ursula M., Wang, Hui, Paton, James C.

The Shiga toxigenic Escherichia coli (STEC) O113:H21 strain 98NK2, which was responsible for an outbreak of hemolytic uremic syndrome, secretes a highly potent and lethal subtilase cytotoxin that is...

Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci

Dessing, Mark C, Florquin, Sandrine, Paton, James C, Van Der Poll, Tom

Toll-like receptors (TLRs) are pattern recognition receptors that recognize conserved molecular patterns expressed by pathogens. Pneumolysin, an intracellular toxin found in all Streptococcus...

Human Cytomegalovirus Specifically Controls the Levels of the Endoplasmic Reticulum Chaperone BiP/GRP78, Which Is Required for Virion Assembly▿

Buchkovich, Nicholas J., Maguire, Tobi G., Yu, Yongjun, Paton, Adrienne W., Paton, James C., Alwine, James C.

The endoplasmic reticulum (ER) chaperone BiP/GRP78 regulates ER function and the unfolded protein response (UPR). Human cytomegalovirus infection of human fibroblasts induces the UPR but modifies it...

Pneumococcal Virulence Gene Expression and Host Cytokine Profiles during Pathogenesis of Invasive Disease▿ †

Mahdi, Layla K., Ogunniyi, Abiodun D., LeMessurier, Kim S., Paton, James C.

Pneumococcal disease continues to account for significant morbidity and mortality worldwide. For the development of novel prophylactic and therapeutic strategies against the disease spectrum, a...