Mulé, James J., Custer, Mary, Averbook, Bruce, Yang, James C., Weber, Jeffrey S., Goeddel, David V., ...
Overview summary Members of the chemokine superfamily mediate potent and selective chemoattraction of a variety of immune cell subsets, which is concentration dependent. This important and novel...
Rosenberg, Steven A., Yannelli, John R., Yang, James C., Topalian, Suzanne L., Schwartzentruber, Douglas J., Weber, Jeffrey S., ...
Background: Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against...
Rosenberg, Steven A., Lotze, Michael T., Yang, James C., Topalian, Suzanne L., Chang, Alfred E., Schwartzentruber, Douglas J., ...
Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in selected patients with advanced...
Griffith, Kean D., Read, Elizabeth J., Carrasquillo, Jorge A., Carter, Charles S., Yang, James C., Fisher, Beth, ...
Patients with metastatic melanoma undergoing therapy with cyclophosphamide (CPM), tumor-infiltrating lymphocytes (TIL), and interleukin-2 (IL-2) were studied for the ability of their 111In-labeled...
Wang, Helen Y., Fu, Tihui, Wang, Gang, Zeng, Gang, Perry-Lalley, Donna M., Yang, James C., ...
Dendritic cell–based (DC-based) immunotherapy represents a promising approach to the prevention and treatment of many diseases, including cancer, but current strategies have met with only limited...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
Cancer immunotherapy: moving beyond current vaccines
Rosenberg, Steven A, Yang, James C, Restifo, Nicholas P
Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on...
Wang, Helen Y., Fu, Tihui, Wang, Gang, Zeng, Gang, Perry-Lalley, Donna M., Yang, James C., ...
Dendritic cell–based (DC-based) immunotherapy represents a promising approach to the prevention and treatment of many diseases, including cancer, but current strategies have met with only limited...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma
Bloom, Matthew B., Perry-Lalley, Donna, Robbins, Paul F., Li, Yong, El-Gamil, Mona, Rosenberg, Steven A., ...
Recently, major advances have been made in the identification of antigens from human melanoma which are recognized by T cells. In spite of this, little is known about the optimal ways to use these...