Shen, Huangxuan, McElhinny, Abigail S., Cao, Yang, Gao, Ping, Liu, Jingxuan, Bronson, Roderick, ...
The MAML (mastermind-like) proteins are a family of three cotranscriptional regulators that are essential for Notch signaling, a pathway critical for cell fate determination. Though the functions of...
Shen, Huangxuan, McElhinny, Abigail S, Cao, Yang, Gao, Ping, Liu, Jingxuan, Bronson, Roderick, ...
The MAML (mastermind-like) proteins are a family of three cotranscriptional regulators that are essential for Notch signaling, a pathway critical for cell fate determination. Though the functions of...
Chen, Jing, Lee, Benjamin H, McDowell, Elizabeth, Adelsperger, Jennifer, ...
AMN107 is a small molecule tyrosine kinase inhibitor developed, in the first instance, as a potent inhibitor of breakpoint cluster region-abelson (BCR-ABL). We tested its effectiveness against fusion...
Wadleigh, Martha, Ebert, Benjamin L, Wernig, Gerlinde, Huntly, Brian J P, ...
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-based protocol was...
Furet, Pascal, Fabbro, Doriano, Clark, Jennifer J, Griffin, James D, ...
Mutations in the receptor tyrosine kinase FLT3 occur frequently in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Small molecules that selectively inhibit FLT3...
Quentmeier, Hilmar, Huntly, Brian J P, Griffin, James D, Drexler, Hans G, ...
We recently identified the chimeric kinase FIP1L1-platelet-derived growth factor receptor alpha (PDGFRalpha) as a cause of the hypereosinophilic syndrome and of chronic eosinophilic leukemia. To...
Stover, Elizabeth H, Boulton, Christina L, Gotlib, Jason, Legare, Robert D, Amaral, Sonia M, ...
FIP1L1-PDGFRalpha causes hypereosinophilic syndrome (HES) and is inhibited by the tyrosine kinase inhibitor imatinib (Gleevec). Imatinib is a potent inhibitor of ABL, ARG, PDGFRalpha, PDGFRbeta, and...
Cools, Jan, DeAngelo, Daniel J., Gotlib, Jason, Stover, Elizabeth H., Legare, Robert D., Cortes, Jorges, ...
BACKGROUND: Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of responses to imatinib in...
DeAngelo, Daniel J, Gotlib, Jason, Stover, Elizabeth H, Legare, Robert D, Cortes, Jorges, ...
BACKGROUND: Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of responses to imatinib in...
Weng, Andrew P, Nam, Yusun, Wolfe, Michael S, Pear, Warren S, Griffin, James D, Blacklow, Stephen C, ...
Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immature T-cell lymphoblastic neoplasms (T-ALLs). Although it is clear that Notch signaling can initiate...
Cools, Jan, DeAngelo, Daniel J., Gotlib, Jason, Stover, Elizabeth. H., Legare, Robert. D., Cortes, Jorges, ...
BACKGROUND: Idiopathic hypereosinophilic syndrome involves a prolonged state of eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of responses to imatinib in...
Vallera, Daniel A., Seo, Su-Yeong, Panoskaltsis-Mortari, Angela, Griffin, James D., Blazar, Bruce R.
The IL-3 receptor was expressed on a high frequency of myeloid leukemia cells and also on hematopoietic and vascular cells. We previously showed that a recombinant IL-3 fusion immunotoxin (DT390IL-3)...
Thesis (M.S.)--National-Louis University, 1990.
The Pregnant Muse: Language and Birth in "A Song of the Rolling Earth" (1983)
Argues that in "A Song of the Rolling Earth" Whitman offers his most complete and in-depth explication of the relation between "two tropes--the unprintable word and the fertile earth...
Sattler, Martin, Verma, Shalini, Byrne, Christopher H., Shrikhande, Gautam, Winkler, Thomas, Algate, Paul A., ...
The BCR/ABL oncogene causes chronic myelogenous leukemia (CML), a myeloproliferative disorder characterized by clonal expansion of hematopoietic progenitor cells and granulocyte lineage cells. The...
Wu, Lizi, Sun, Tao, Kobayashi, Karla, Gao, Ping, Griffin, James D.
The molecular mechanisms by which Notch receptors induce diverse biological responses are not fully understood. We recently cloned a mammalian homologue of the Mastermind gene of Drosophila...
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
Weng, Andrew P., Nam, Yunsun, Wolfe, Michael S., Pear, Warren S., Griffin, James D., Blacklow, Stephen C., ...
Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immature T-cell lymphoblastic neoplasms (T-ALLs). Although it is clear that Notch signaling can initiate...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Coleman, Annette W., Coleman, John R., Griffin, James D., Weltman, Joel K., Chapman, K. M.
Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation
Wu, Lizi, Liu, Jingxuan, Gao, Ping, Nakamura, Makoto, Cao, Yang, Shen, Huangxuan, ...
Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment. A specific recurring t(11;19)(q21;p13)...
Shen, Huangxuan, McElhinny, Abigail S., Cao, Yang, Gao, Ping, Liu, Jingxuan, Bronson, Roderick, ...
The MAML (mastermind-like) proteins are a family of three cotranscriptional regulators that are essential for Notch signaling, a pathway critical for cell fate determination. Though the functions of...
Sattler, Martin, Verma, Shalini, Byrne, Christopher H., Shrikhande, Gautam, Winkler, Thomas, Algate, Paul A., ...
The BCR/ABL oncogene causes chronic myelogenous leukemia (CML), a myeloproliferative disorder characterized by clonal expansion of hematopoietic progenitor cells and granulocyte lineage cells. The...
Wu, Lizi, Sun, Tao, Kobayashi, Karla, Gao, Ping, Griffin, James D.
The molecular mechanisms by which Notch receptors induce diverse biological responses are not fully understood. We recently cloned a mammalian homologue of the Mastermind gene of Drosophila...
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
Weng, Andrew P., Nam, Yunsun, Wolfe, Michael S., Pear, Warren S., Griffin, James D., Blacklow, Stephen C., ...
Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immature T-cell lymphoblastic neoplasms (T-ALLs). Although it is clear that Notch signaling can initiate...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Coleman, Annette W., Coleman, John R., Griffin, James D., Weltman, Joel K., Chapman, K. M.
Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation
Wu, Lizi, Liu, Jingxuan, Gao, Ping, Nakamura, Makoto, Cao, Yang, Shen, Huangxuan, ...
Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment. A specific recurring t(11;19)(q21;p13)...
Shen, Huangxuan, McElhinny, Abigail S., Cao, Yang, Gao, Ping, Liu, Jingxuan, Bronson, Roderick, ...
The MAML (mastermind-like) proteins are a family of three cotranscriptional regulators that are essential for Notch signaling, a pathway critical for cell fate determination. Though the functions of...
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
Zhang, Hongbing, Bajraszewski, Natalia, Wu, Erxi, Wang, Hongwei, Moseman, Annie P., Dabora, Sandra L., ...
The receptor tyrosine kinase/PI3K/Akt/mammalian target of rapamycin (RTK/PI3K/Akt/mTOR) pathway is frequently altered in tumors. Inactivating mutations of either the TSC1 or the TSC2 tumor-suppressor...
Levine, Ross L., Loriaux, Marc, Huntly, Brian J. P., Loh, Mignon L., Beran, Miroslav, Stoffregen, Eric, ...
Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies. Recently, we and others identified a single recurrent somatic activating mutation...
Growney, Joseph D., Clark, Jennifer J., Adelsperger, Jennifer, Stone, Richard, Fabbro, Doriano, Griffin, James D., ...
Constitutively activated forms of the transmembrane receptor tyrosine kinase c-KIT have been associated with systemic mast cell disease, acute myeloid leukemia, and gastrointestinal stromal tumors....
Stover, Elizabeth H., Chen, Jing, Lee, Benjamin H., Cools, Jan, McDowell, Elizabeth, Adelsperger, Jennifer, ...
AMN107 is a small molecule tyrosine kinase inhibitor developed, in the first instance, as a potent inhibitor of breakpoint cluster region-abelson (BCR-ABL). We tested its effectiveness against fusion...
Sattler, Martin, Walz, Christoph, Crowley, Brian J., Lengfelder, Eva, Jänne, Pasi A., Rogers, Andrew M., ...
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias
Weisberg, Ellen, Catley, Laurie, Wright, Renee D., Moreno, Daisy, Banerji, Lolita, Ray, Arghya, ...
Drug resistance resulting from emergence of imatinib-resistant BCR-ABL point mutations is a significant problem in advanced-stage chronic myelogenous leukemia (CML). The BCR-ABL inhibitor, nilotinib...
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia
Loriaux, Marc M., Levine, Ross L., Tyner, Jeffrey W., Fröhling, Stefan, Scholl, Claudia, Stoffregen, Eric P., ...
To determine whether aberrantly activated tyrosine kinases other than FLT3 and c-KIT contribute to acute myeloid leukemia (AML) pathogenesis, we used high-throughput (HT) DNA sequence ana-lysis to...
Following the cytokine signaling pathway to leukemogenesis: a chronology
Smith, Kendall A., Griffin, James D.
Studies over the past 50 years revealing the molecular events that promote normal T lymphocyte cycle competence and progression led to a detailed understanding of how cytokines function to regulate...
Wu, Lizi, Maillard, Ivan, Nakamura, Makoto, Pear, Warren S., Griffin, James D.
Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while...
Weisberg, Ellen, Banerji, Lolita, Wright, Renee D., Barrett, Rosemary, Ray, Arghya, Moreno, Daisy, ...
Mediators of PI3K/AKT signaling have been implicated in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Studies have shown that inhibitors of PI3K/AKT signaling, such as wortmannin...
Wernig, Gerlinde, Gonneville, Jeffrey R., Crowley, Brian J., Rodrigues, Margret S., Reddy, Mamatha M., Hudon, Heidi E., ...
The V617F activating point mutation in Jak2 is associated with a proportion of myeloproliferative disorders. In normal hematopoietic cells, Jak2 signals only when associated with a growth factor...