Doern, Gary V., Jorgensen, James H., Thornsberry, Clyde, Preston, David A., Tubert, Tracy A., Redding, Judith S., ...
A total of 2,811 clinical isolates of Haemophilus influenzae were obtained during 1986 from 30 medical centers and one nationwide private independent laboratory in the United States. Among these, 757...
Jorgensen, James H., Salinas, Jesse R., Paxson, Rosemary, Magnon, Karen, Patterson, Jan E., Patterson, Thomas F.
The Gen-Probe Amplified Mycobacterium Tuberculosis Direct (MTD) test has been approved for use in the United States for the rapid diagnosis of pulmonary tuberculosis in patients with acid-fast...
Tenover, Fred C., Jones, Ronald N., Swenson, Jana M., Zimmer, Barbara, McAllister, Sigrid, Jorgensen, James H.
A multilaboratory study was undertaken to determine the accuracy of the current National Committee for Clinical Laboratory Standards (NCCLS) oxacillin breakpoints for broth microdilution and disk...
Jorgensen, James H., Barry, Arthur L., Traczewski, M. M., Sahm, Daniel F., McElmeel, M. Leticia, Crawford, Sharon A.
The VITEK 2 is a new automated instrument for rapid organism identification and susceptibility testing. It has the capability of performing rapid susceptibility testing of Streptococcus pneumoniae...
McDougal, Linda K., Tenover, Fred C., Lee, Linda N., Rasheed, J. Kamile, Patterson, Jan E., Jorgensen, James H., ...
A series of macrolide-lincosamide-streptogramin B (MLS)-resistant pneumococcal isolates of a variety of serotypes was examined and was found to contain Tn917-like elements by DNA-DNA hybridization....
Baum, Sue E., Crawford, Sharon A., McElmeel, M. L., Whitney, Cynthia G., Jorgensen, James H.
The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 μg/ml and 0.5...
Almeida, Roy J., Jorgensen, James H.
Special novobiocin elution disks were prepared for testing of coagulase-negative staphylococci in the MS-2 system (Abbott Laboratories, Diagnostics Div., Irving, Tex.). The MS-2 system correctly...
Jorgensen, James H., Crawford, Sharon A., Kelly, Cynthia C., Patterson, Jan E.
The increasing prevalence of vancomycin-resistant enterococcal (VRE) infections and the limited number of antimicrobial agents for their treatment emphasize a need for new, more effective agents. In...
Jorgensen, James H., Crawford, Sharon A., McElmeel, M. Leticia, Whitney, Cynthia G.
The in vitro activities of two investigational ketolides, cethromycin (formerly ABT-773) and telithromycin, were determined for a selected group of 312 Streptococcus pneumoniae isolates from a...
Jorgensen, James H., Lee, Jean C., Alexander, Gary A.
A modified 1-min iodometric paper strip test for penicillinase activity was developed for detection of beta-lactamase-producing isolates of Haemophilus influenzae and Neisseria gonorrhoeae. The test...
Comparative Activities of Selected Beta-Lactam Antibiotics Against Haemophilus influenzae
Jorgensen, James H., Alexander, Gary A.
The comparative activities of ampicillin, cefamandole, cefoxitin, cefaclor, and cefatrizine against both beta-lactamase-producing and non-beta-lactamase-producing isolates of Haemophilus influenzae...
Preparation, Sensitivity, and Specificity of Limulus Lysate for Endotoxin Assay
Jorgensen, James H., Smith, Rodney F.
Limulus amoebocyte lysate was prepared from a total of 180 crabs during 1971 and 1972 by using a slightly modified lysate preparation procedure. Marked variability of lysate potency was noted both...
Rapid Detection of Contaminated Intravenous Fluids Using the Limulus In Vitro Endotoxin Assay
Jorgensen, James H., Smith, Rodney F.
Intravenous fluids and administration sets may become contaminated with gram-negative bacteria during use and result in a life-threatening situation to the patient. The Limulus in vitro assay for...
Characterization of Staphylococcus aureus in a Pediatric Burn Unit
Smith, Rodney F., Bettge, Carol L., Dayton, Sandra L., Jorgensen, James H.
A one-year study on an endemic strain of Staphylococcus aureus phage type 84/85 in a children's burn unit is described. The endemic strain rapidly colonized the burns and nares of acute patients...
Simplified Medium for Ampicillin Susceptibility Testing of Haemophilus influenzae
Jorgensen, James H., Jones, Pamela M.
Recent reports of bona fide ampicillin resistance among strains of Haemophilus influenzae have emphasized the need for improved methods of susceptibility testing of clinical isolates. A simplified...
Microdilution Technique for Antimicrobial Susceptibility Testing of Haemophilus influenzae
Jorgensen, James H., Lee, Jean C.
A microdilution method incorporating the use of color-defined growth end points was compared with a conventional broth tube dilution procedure for susceptibility testing of Haemophilus influenzae...
Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin
Schrag, Stephanie J., McGee, Lesley, Whitney, Cynthia G., Beall, Bernard, Craig, Allen S., Choate, Miriam E., ...
Penicillin resistance threatens the treatment of pneumococcal infections. We used sentinel hospital surveillance (1978 to 2001) and population-based surveillance (1995 to 2001) in seven states in the...
International Clone of Neisseria meningitidis Serogroup A with Tetracycline Resistance Due to tet(B)
Crawford, Sharon A., Fiebelkorn, Kristin R., Patterson, Jan E., Jorgensen, James H.
Thirteen Neisseria meningitidis clinical isolates from Africa, Asia, and the United States for which the tetracycline MICs were elevated (≥8 μg/ml) were examined for 14 recognized resistance...
Emergence of Daptomycin Resistance in Enterococcus faecium during Daptomycin Therapy
Sabol, Kathryn, Patterson, Jan E., Lewis, James S., Owens, Aaron, Cadena, Jose, Jorgensen, James H.
Zelazny, Adrian M., Ferraro, Mary Jane, Glennen, Anita, Hindler, Janet F., Mann, Linda M., Munro, Susan, ...
A nine-laboratory collaborative study was conducted to select positive and negative quality assessment control strains for the detection of inducible clindamycin resistance in staphylococci. Four...
Jorgensen, James H., Crawford, Sharon A., Fiebelkorn, Kristin R.
Neisseria meningitidis represents a pathogen of great public health importance in both developed and developing countries. Resistance to some antimicrobial agents used either for therapy of invasive...
Wolter, Nicole, Smith, Anthony M., Farrell, David J., Schaffner, William, Moore, Matthew, Whitney, Cynthia G., ...
Two clinical Streptococcus pneumoniae isolates, identified as resistant to macrolides and chloramphenicol and nonsusceptible to linezolid, were found to contain 6-bp deletions in the gene encoding...
Failure of Cefepime Therapy in Treatment of Klebsiella pneumoniae Bacteremia
Song, Wonkeun, Moland, Ellen S., Hanson, Nancy D., Lewis, James S., Jorgensen, James H., Thomson, Kenneth S.
A case of failure of cefepime treatment of a bloodstream infection with AmpC-producing Klebsiella pneumoniae is reported. The failure was attributed to extended-spectrum β-lactamase (ESBL)...
Davis, Kepler A., Crawford, Sharon A., Fiebelkorn, Kristin R., Jorgensen, James H.
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not...
Gunn, Shelly R., Reveles, Xavier T., Hamlington, Jeanette D., Sadkowski, Lee C., Johnson-Pais, Teresa L., Jorgensen, James H.
This is the first reported case of human disease caused by Tricosporon dermatis, an organism recently transferred to the genus Trichosporon from Cryptococcus and now confirmed to be a human pathogen.
Jorgensen, James H., Crawford, Sharon A., Fulcher, Letitia C., Glennen, Anita, Harrington, Susan M., Swenson, Jana, ...
In 2005, the Clinical and Laboratory Standards Institute published MIC interpretive criteria for 13 antimicrobial agents used for either therapy or prophylaxis of Neisseria meningitidis infections....
Assessment of Two Commercial Susceptibility Test Methods for Determination of Daptomycin MICs
Jorgensen, James H., Crawford, Sharon A.
Daptomycin is a lipopeptide antibiotic with activity against several important gram-positive bacterial pathogens, including drug-resistant staphylococci and enterococci. Because the mechanism of...
Jorgensen, James H., Salinas, Jesse R., Paxson, Rosemary, Magnon, Karen, Patterson, Jan E., Patterson, Thomas F.
The Gen-Probe Amplified Mycobacterium Tuberculosis Direct (MTD) test has been approved for use in the United States for the rapid diagnosis of pulmonary tuberculosis in patients with acid-fast...
Tenover, Fred C., Jones, Ronald N., Swenson, Jana M., Zimmer, Barbara, McAllister, Sigrid, Jorgensen, James H.
A multilaboratory study was undertaken to determine the accuracy of the current National Committee for Clinical Laboratory Standards (NCCLS) oxacillin breakpoints for broth microdilution and disk...
Jorgensen, James H., Barry, Arthur L., Traczewski, M. M., Sahm, Daniel F., McElmeel, M. Leticia, Crawford, Sharon A.
The VITEK 2 is a new automated instrument for rapid organism identification and susceptibility testing. It has the capability of performing rapid susceptibility testing of Streptococcus pneumoniae...
McDougal, Linda K., Tenover, Fred C., Lee, Linda N., Rasheed, J. Kamile, Patterson, Jan E., Jorgensen, James H., ...
A series of macrolide-lincosamide-streptogramin B (MLS)-resistant pneumococcal isolates of a variety of serotypes was examined and was found to contain Tn917-like elements by DNA-DNA hybridization....
Baum, Sue E., Crawford, Sharon A., McElmeel, M. L., Whitney, Cynthia G., Jorgensen, James H.
The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 μg/ml and 0.5...
Almeida, Roy J., Jorgensen, James H.
Special novobiocin elution disks were prepared for testing of coagulase-negative staphylococci in the MS-2 system (Abbott Laboratories, Diagnostics Div., Irving, Tex.). The MS-2 system correctly...
Jorgensen, James H., Crawford, Sharon A., Kelly, Cynthia C., Patterson, Jan E.
The increasing prevalence of vancomycin-resistant enterococcal (VRE) infections and the limited number of antimicrobial agents for their treatment emphasize a need for new, more effective agents. In...
Jorgensen, James H., Crawford, Sharon A., McElmeel, M. Leticia, Whitney, Cynthia G.
The in vitro activities of two investigational ketolides, cethromycin (formerly ABT-773) and telithromycin, were determined for a selected group of 312 Streptococcus pneumoniae isolates from a...
Jorgensen, James H., Lee, Jean C., Alexander, Gary A.
A modified 1-min iodometric paper strip test for penicillinase activity was developed for detection of beta-lactamase-producing isolates of Haemophilus influenzae and Neisseria gonorrhoeae. The test...
Comparative Activities of Selected Beta-Lactam Antibiotics Against Haemophilus influenzae
Jorgensen, James H., Alexander, Gary A.
The comparative activities of ampicillin, cefamandole, cefoxitin, cefaclor, and cefatrizine against both beta-lactamase-producing and non-beta-lactamase-producing isolates of Haemophilus influenzae...
Preparation, Sensitivity, and Specificity of Limulus Lysate for Endotoxin Assay
Jorgensen, James H., Smith, Rodney F.
Limulus amoebocyte lysate was prepared from a total of 180 crabs during 1971 and 1972 by using a slightly modified lysate preparation procedure. Marked variability of lysate potency was noted both...
Rapid Detection of Contaminated Intravenous Fluids Using the Limulus In Vitro Endotoxin Assay
Jorgensen, James H., Smith, Rodney F.
Intravenous fluids and administration sets may become contaminated with gram-negative bacteria during use and result in a life-threatening situation to the patient. The Limulus in vitro assay for...
Characterization of Staphylococcus aureus in a Pediatric Burn Unit
Smith, Rodney F., Bettge, Carol L., Dayton, Sandra L., Jorgensen, James H.
A one-year study on an endemic strain of Staphylococcus aureus phage type 84/85 in a children's burn unit is described. The endemic strain rapidly colonized the burns and nares of acute patients...
Simplified Medium for Ampicillin Susceptibility Testing of Haemophilus influenzae
Jorgensen, James H., Jones, Pamela M.
Recent reports of bona fide ampicillin resistance among strains of Haemophilus influenzae have emphasized the need for improved methods of susceptibility testing of clinical isolates. A simplified...
Microdilution Technique for Antimicrobial Susceptibility Testing of Haemophilus influenzae
Jorgensen, James H., Lee, Jean C.
A microdilution method incorporating the use of color-defined growth end points was compared with a conventional broth tube dilution procedure for susceptibility testing of Haemophilus influenzae...
Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin
Schrag, Stephanie J., McGee, Lesley, Whitney, Cynthia G., Beall, Bernard, Craig, Allen S., Choate, Miriam E., ...
Penicillin resistance threatens the treatment of pneumococcal infections. We used sentinel hospital surveillance (1978 to 2001) and population-based surveillance (1995 to 2001) in seven states in the...
International Clone of Neisseria meningitidis Serogroup A with Tetracycline Resistance Due to tet(B)
Crawford, Sharon A., Fiebelkorn, Kristin R., Patterson, Jan E., Jorgensen, James H.
Thirteen Neisseria meningitidis clinical isolates from Africa, Asia, and the United States for which the tetracycline MICs were elevated (≥8 μg/ml) were examined for 14 recognized resistance...
Emergence of Daptomycin Resistance in Enterococcus faecium during Daptomycin Therapy
Sabol, Kathryn, Patterson, Jan E., Lewis, James S., Owens, Aaron, Cadena, Jose, Jorgensen, James H.
Zelazny, Adrian M., Ferraro, Mary Jane, Glennen, Anita, Hindler, Janet F., Mann, Linda M., Munro, Susan, ...
A nine-laboratory collaborative study was conducted to select positive and negative quality assessment control strains for the detection of inducible clindamycin resistance in staphylococci. Four...
Davis, Kepler A., Crawford, Sharon A., Fiebelkorn, Kristin R., Jorgensen, James H.
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not...
Jorgensen, James H., Crawford, Sharon A., Fiebelkorn, Kristin R.
Neisseria meningitidis represents a pathogen of great public health importance in both developed and developing countries. Resistance to some antimicrobial agents used either for therapy of invasive...
Wolter, Nicole, Smith, Anthony M., Farrell, David J., Schaffner, William, Moore, Matthew, Whitney, Cynthia G., ...
Two clinical Streptococcus pneumoniae isolates, identified as resistant to macrolides and chloramphenicol and nonsusceptible to linezolid, were found to contain 6-bp deletions in the gene encoding...
Failure of Cefepime Therapy in Treatment of Klebsiella pneumoniae Bacteremia
Song, Wonkeun, Moland, Ellen S., Hanson, Nancy D., Lewis, James S., Jorgensen, James H., Thomson, Kenneth S.
A case of failure of cefepime treatment of a bloodstream infection with AmpC-producing Klebsiella pneumoniae is reported. The failure was attributed to extended-spectrum β-lactamase (ESBL)...
Gunn, Shelly R., Reveles, Xavier T., Hamlington, Jeanette D., Sadkowski, Lee C., Johnson-Pais, Teresa L., Jorgensen, James H.
This is the first reported case of human disease caused by Tricosporon dermatis, an organism recently transferred to the genus Trichosporon from Cryptococcus and now confirmed to be a human pathogen.
Jorgensen, James H., Crawford, Sharon A., Fulcher, Letitia C., Glennen, Anita, Harrington, Susan M., Swenson, Jana, ...
In 2005, the Clinical and Laboratory Standards Institute published MIC interpretive criteria for 13 antimicrobial agents used for either therapy or prophylaxis of Neisseria meningitidis infections....
Assessment of Two Commercial Susceptibility Test Methods for Determination of Daptomycin MICs
Jorgensen, James H., Crawford, Sharon A.
Daptomycin is a lipopeptide antibiotic with activity against several important gram-positive bacterial pathogens, including drug-resistant staphylococci and enterococci. Because the mechanism of...
Susceptibility of Acinetobacter Strains Isolated from Deployed U.S. Military Personnel▿
Hawley, Joshua S., Murray, Clinton K., Griffith, Matthew E., McElmeel, M. Leticia, Fulcher, Letitia C., Hospenthal, Duane R., ...
The susceptibilities of 142 Acinetobacter baumannii-calcoaceticus complex isolates (95 from wounded U.S. soldiers deployed overseas) to 13 antimicrobial agents were determined by broth microdilution....
Ellis, Michael W., Griffith, Matthew E., Dooley, David P., McLean, Joseph C., Jorgensen, James H., Patterson, Jan E., ...
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen that primarily manifests as uncomplicated skin and soft tissue infections. We conducted a cluster...
Lewis, James S., Herrera, Monica, Wickes, Brian, Patterson, Jan E., Jorgensen, James H.
CTX-M-type extended-spectrum β-lactamases (ESBLs) have become increasingly common worldwide, with the notable exception of the United States, where TEM- and SHV-type ESBLs have appeared to...
Colistin Heteroresistance in Acinetobacter and Its Association with Previous Colistin Therapy▿
Hawley, Joshua S., Murray, Clinton K., Jorgensen, James H.
Colistin heteroresistance has been reported among Acinetobacter isolates; however, its association with prior colistin therapy has not been not described. A population analysis profile identified...
Holmes, Robert L., Jorgensen, James H.
We assessed MICs and minimal bactericidal concentrations of vancomycin, daptomycin, and nine other antimicrobials against methicillin-resistant Staphylococcus aureus isolates obtained from 1999...
Ressner, Roseanne A., Moore, Matthew R., Jorgensen, James H.
Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active,...
Bennett, Jason W., Herrera, Monica L., Lewis, James S., Wickes, Brian W., Jorgensen, James H.
Carbapenemases are among the newest resistance mechanisms to emerge in some gram-negative bacteria. We describe bacteremia in a critically ill liver transplant recipient infected with KPC-2-producing...
Prakash, Vidhya, Lewis, James S., Herrera, Monica L., Wickes, Brian L., Jorgensen, James H.
Effective therapeutic options are needed for community-onset urinary tract infections due to Escherichia coli strains that produce CTX-M extended-spectrum β-lactamases. We examined 46 urinary...
Ellis, Michael W., Griffith, Matthew E., Jorgensen, James H., Hospenthal, Duane R., Mende, Katrin, Patterson, Jan E.
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of skin and soft-tissue infections (SSTI). The understanding of the molecular epidemiology and virulence of MRSA...