James J. Goedert

Immunodeficiency Virus Infection (2008)

Philip G. Mcqueen, James J. Goedert, Richard A. Kaslow

Complex immunogenetic associations of disease involving a large number of gene products are difficult to evaluate with traditional statistical methods and may require complex modeling. The authors...

AIDS-Related Cancer and Severity of Immunosuppression in Persons With AIDS (2007)

Biggar, Robert J., Chaturvedi, Anil K., Goedert, James J., Engels, Eric A.

Background The incidence of Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer has been declining among persons with AIDS. We investigated the association between cancer risk and CD4 cell...

Regulatory Polymorphisms in the Cyclophilin A Gene, PPIA, Accelerate Progression to AIDS (2007)

Ping An, Li Hua Wang, Holli Hutcheson-Dilks, George Nelson, Sharyne Donfield, James J. Goedert, ...

Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus...

Reconstruction of the Hepatitis C Virus Epidemic in the US Hemophilia Population, 1940-1990 (2007)

Goedert, James J., Chen, Bingshu E., Preiss, Liliana, Aledort, Louis M., Rosenberg, Philip S.

Hepatitis C virus (HCV) is a blood-borne infection readily transmitted by transfusion. Persons with hemophilia were at very high risk of acquiring HCV, but the chronology and correlates of HCV...

Polymorphisms of CUL5 Are Associated with CD4+ T Cell Loss in HIV-1 Infected Individuals (2007)

Ping An, Priya Duggal, Li Hua Wang, Stephen J. O'Brien, Sharyne Donfield, James J. Goedert, ...

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1....

KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections (2006)

Ying Qi, Maureen P. Martin, Xiaojiang Gao, Lisa Jacobson, James J. Goedert, Susan Buchbinder, ...

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...

Lymphocyte subsets in hemophilic patients with hepatitis C virus infection with or without human immunodeficiency virus co-infection: a nested cross-sectional study (2005)

Zhang, Mingdong, O'Brien, Thomas R, Kopp, William C, Goedert, James J

Abstract Background With chronic infection, hepatitis C virus (HCV) RNA can be detected in B cells and associated with B-cell disorders, but these are not well defined. Methods The relationship...

Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma (2005)

Brown, Elizabeth E, Whitby, Denise, Vitale, Francesco, Fei, Paola Cordiali, Del Carpio, Carla, Marshall, Vickie, ...

Background The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA...

Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma (2005)

Brown, Elizabeth E., Whitby, Denise, Vitale, Francesco, Cordiali Fei, Paola, Del Carpio, Carla, Marshall, Vickie, ...

Background The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA...

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection (2004)

Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, ...

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of...

A High-Density Admixture Map for Disease Gene Discovery in African Americans (2004)

Smith, Michael W, Patterson, Nick, Lautenberger, James A, Truelove, Ann L, McDonald, Gavin J, Waliszewska, Alicja, ...

Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans,...

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection (2004)

Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, ...

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of...

Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. (2004)

Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...

Trends in U.S. Pleural Mesothelioma Incidence Rates Following Simian Virus 40 Contamination of Early Poliovirus Vaccines (2003)

Strickler, Howard D., Goedert, James J., Devesa, Susan S., Lahey, John, Fraumeni, Joseph F., Rosenberg, Philip S.

Background: Poliovirus vaccines that were used during the late 1950s and early 1960s were contaminated with simian virus 40 (SV40), a monkey virus that is tumorigenic in rodents. SV40 DNA sequences...

Human Herpesvirus 8 Infection and Transfusion History in Children With Sickle-Cell Disease in Uganda (2003)

Mbulaiteye, Sam M., Biggar, Robert J., Bakaki, Paul M., Pfeiffer, Ruth M., Whitby, Denise, Owor, Anchilla M., ...

Background: Although human herpesvirus 8 (HHV-8), the etiologic agent for Kaposi’s sarcoma, can be detected in peripheral blood, blood-borne transmission of this virus has not been demonstrated. We...

New Challenges to Health: The Threat of Virus Infection (review) (2002)

Goedert, James J.

Perspectives in Biology and Medicine - Volume 45, Number 2, Spring 2002

Kaposi's sarcoma-associated herpesvirus infection in elderly Jews and non-Jews from New York City (2002)

Engels, Eric A, Clark, Elizabeth, Aledort, Louis M, Goedert, James J, Whitby, Denise

Background Worldwide, Kaposi’s sarcoma (KS) occurs in immunocompetent elderly adults, especially men. Elderly Jews have relatively high KS risk, but it is unclear whether this indicates heightened...

Risk Factors for Classical Kaposi’s Sarcoma (2002)

Goedert, James J., Vitale, Francesco, Lauria, Carmela, Serraino, Diego, Tamburini, Mario, Montella, Maurizio, ...

Background: Classical Kaposi’s sarcoma (KS) is a malignancy of lymphatic endothelial skin cells. Although all forms of KS are associated with the KS-associated herpesvirus (KSHV), classical KS...

Antibodies to human herpes virus type 8 (HHV8) in general population and in individuals at risk for sexually transmitted diseases in Western Sicily (2000)

Perna, Anna Maria, Bonura, Filippa, Vitale, Francesco, Viviano, Enza, Di Benedetto, Maria Antonella, Ajello, Francesca, ...

Background Human herpes virus 8 (HHV8) appears to be the primary aetiologic agent of Kaposi sarcoma (KS). To study the distribution of HHV8, a seroepidemiological study was carried out in western...

Ser-249 p53 Mutations in Plasma DNA of Patients With Hepatocellular Carcinoma From The Gambia (2000)

Kirk, Gregory D., Camus-Randon, Anne-Marie, Mendy, Maimuna, Goedert, James J., Merle, Philippe, Trépo, Christian, ...

BACKGROUND: A selective mutation, an arginine-to-serine substitution in codon 249, of the p53 gene has been identified as a “hotspot” mutation in hepatocellular carcinoma (HCC). This mutation...

Human Papillomavirus-Associated Cancers in Patients With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome (2000)

Frisch, Morten, Biggar, Robert J., Goedert, James J.

Background: Human papillomavirus (HPV)-associated anogenital malignancies occur frequently in patients with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome...

Use of Neural Networks to Model Complex Immunogenetic Associations of Disease: Human Leukocyte Antigen Impact on the Progression of Human Immunodeficiency Virus Infection (1998)

Ioannidis, John P. A., McQueen, Philip G., Goedert, James J., Kaslow, Richard A.

Complex immunogenetic associations of disease involving a learge number of gene products are difficult to evaluate with traditional statistical methods and may require complex modeling. The authors...

Progression to Acquired Immunodeficiency Syndrome Is Influenced by CD4 T-Lymphocyte Count and Time Since Seroconversion (1997)

Begtrup, Kamilla, Melbye, Mads, Biggar, Robert J., Goedert, James J., Knudsen, Kim, Anderson, Per Kragh

Progression to acquired immunodeficiency syndrome (AIDS) among persons infected with human immunodeficiency virus (HIV) varies considerably and may be influenced by factors such as age, smoking,...

Prognostic Factors for All-Cause Mortality among Hemophiliacs Infected with Human Immunodeficiency Virus (1995)

Diamondstone, Laura S., Blakley, Sally A., Rice, Janet C., Clark, Rebecca A., Goedert, James J.

To identify the prognostic significance of hemophilia- and virus-related factors, the authors undertook a survival analysis among 644 human immunodeficiency virus (HIV)-infected subjects enrolled in...

Mortality among Drug Users in the AIDS Era (1995)

GOEDERT, JAMES J, PIZZA, GIANCARLO, GRITTI, FRANCESCO M, COSTIGLIOLA, PAOLO, BOSCHINI, ANTONIO, BINI, ALESSANDRA, ...

Background Infection with human immunodeficiency virus type 1 (HIV-1) causes progressive immune deficiency, the acquired immunodeficiency syndrome (AIDS), and death. Mortality, however, particularly...

Immunologic Markers of Progression to Acquired Immunodeficiency Syndrome are Time-Dependent and Illness-Specific (1992)

Krämer, Alexander, Biggar, Robert J., Hampl, Hartmut, Friedman, Robert M., Fuchs, Dietmar, Wachter, Helmut, ...

Since prevalent cohorts may be biased by the duration of human immunodeficiency virus (HIV) infection (onset bias), it is useful to assess the potential predictive value of markers in incident...

Projections of the Incidence of Non-Hodgkin's Lymphoma Related to Acquired Immunodeficiency Syndrome (1991)

Gail, Mitchell H., Pluda, James M., Rabkin, Charles S., Biggar, Robert J., Goedert, James J., Horm, John W., ...

Advances in antiretroviral therapy and treatment or prophylaxis against opportunistic infections have resulted in prolongation of the survival of patients with acquired immunodeficiency syndrome...

Backcalculation of the Number with Human Immunodeficiency Virus Infection in the United States (1991)

Rosenberg, Philip S., Biggar, Robert J., Goedert, James J., Gail, Mitchell H.

The method of backcalculation was applied to national surveillance data on the acquired immunodefidency syndrome (AIDS) in order to estimate the cumulative number of adults with human...

CANCER IN A GROUP AT RISK OF ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) THROUGH 1984 (1987)

BIGGAR, ROBERT J., HORM, JOHN, GOEDERT, JAMES J., MELBYE, MADS

Blggar, R. J. (National Cancer Institute, NIH, Bethesda, MD 20892), J. Horm, J. J. Goedert, and M. Melbye. Cancer in a group at risk of acquired immunodeficiency syndrome (AIDS) through 1984. Am J...

DECREASED HELPER T LYMPHOCYTES IN HOMOSEXUAL MEN: I. SEXUAL CONTACT IN HIGH-INCHDENCE AREAS FOR THE ACQUIRED IMMUNODEFICIENCY SYNDROME (1985)

GOEDERT, JAMES J., BIGGAR, ROBERT J., WINN, DEBORAH M., MANN, DEAN L., BYAR, DAVID P., STRONG, DOUGLAS M., ...

In June 1982, sexual and other behavioral patterns were examined in 245 homosexual men in relationship to T-lymphocyte phenotypes that are character istic of the acquired Immunodeficiency syndrome...

DECREASED HELPER T LYMPHOCYTES IN HOMOSEXUAL MEN: II. SEXUAL PRACTICES (1985)

GOEDERT, JAMES J., BIGGAR, ROBERT J., WINN, DEBORAH M., MANN, DEAN L., BYAR, DAVID P., STRONG, DOUGLAS M., ...

Goedert, J. J. (Environmental Epidemiology Branch, Nd, Bethesda, MD 20205), R. J. Biggar, D. M. Winn, D. L Mann, D. P. Byar, D. M. Strong, R. A. DiGlola, R. J. Grossman, W. C. Sanchez, R. G. Kase, M....

A simple relationship between viral load and survival time in HIV-1 infection

Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.

Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...

Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

Shin, Hyoung Doo, Winkler, Cheryl, Stephens, J. Claiborne, Bream, Jay, Young, Howard, Goedert, James J., ...

IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of...

Modulating influence on HIV/AIDS by interacting RANTES gene variants

An, Ping, Nelson, George W., Wang, Lihua, Donfield, Sharyne, Goedert, James J., Phair, John, ...

RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro. We tested the influence of four RANTES...

HLA-Cw*04 and Hepatitis C Virus Persistence

Thio, Chloe L., Gao, Xiaojiang, Goedert, James J., Vlahov, David, Nelson, Kenrad E., Hilgartner, Margaret W., ...

In studies of acute hepatitis C virus (HCV) infection, the early host immune response is one of the determinants of viral persistence. The class I human leukocyte antigens (HLA), which present...

Quantitation of Human Immunodeficiency Virus Type 1 DNA Forms with the Second Template Switch in Peripheral Blood Cells Predicts Disease Progression Independently of Plasma RNA Load

Kostrikis, Leondios G., Touloumi, Giota, Karanicolas, Rose, Pantazis, Nikos, Anastassopoulou, Cleo, Karafoulidou, Anastasia, ...

There are several forms of human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood T cells and lymph nodes in untreated HIV-1-infected individuals and in patients whose plasma HIV-1 RNA...

Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes

Jin, Xia, Gao, Xiaojiang, Deschenes, Geoffrey R., Nelson, George W., O'Brien, Stephen J., ...

Human immunodeficiency virus type 1 (HIV-1)-infected individuals with HLA-B*35 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3501 (B*35-PY). The...

Distribution of Chemokine Receptor CCR2 and CCR5 Genotypes and Their Relative Contribution to Human Immunodeficiency Virus Type 1 (HIV-1) Seroconversion, Early HIV-1 RNA Concentration in Plasma, and Later Disease Progression

Tang, Jianming, Shelton, Brent, Makhatadze, Nina J., Zhang, Yuting, Schaen, Margaret, Louie, Leslie G., ...

At the CC (β) chemokine receptor 2 (CCR2) and CCR5 loci, combinations of common single-nucleotide polymorphisms (SNPs) and a 32-bp deletion (Δ32) form nine stable haplotypes (designated A through...

Comprehensive Analysis of Class I and Class II HLA Antigens and Chronic Hepatitis B Virus Infection

Thio, Chloe L., Thomas, David L., Karacki, Peter, Gao, Xiaojiang, Marti, Darlene, Kaslow, Richard A., ...

Following an acute hepatitis B virus (HBV) infection, clearance or persistence is determined in part by the vigor and breadth of the host immune response. Since the human leukocyte antigen system...

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS†

An, Ping, Bleiber, Gabriela, Duggal, Priya, Nelson, George, May, Margaret, Mangeat, Bastien, ...

The cytosine deaminase APOBEC3G, in the absence of the human immunodeficiency virus type 1 (HIV-1) accessory gene HIV-1 viral infectivity factor (vif), inhibits viral replication by introducing G→A...

Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection

Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...

KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections

Qi, Ying, Martin, Maureen P, Gao, Xiaojiang, Jacobson, Lisa, Goedert, James J, Buchbinder, Susan, ...

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...

Consistent Effects of TSG101 Genetic Variability on Multiple Outcomes of Exposure to Human Immunodeficiency Virus Type 1†

Bashirova, Arman A., Bleiber, Gabriela, Qi, Ying, Hutcheson, Holli, Yamashita, Traci, Johnson, Randall C., ...

Tumor susceptibility gene 101 (TSG101) encodes a host cellular protein that is appropriated by human immunodeficiency virus type 1 (HIV-1) in the budding process of viral particles from infected...

A simple relationship between viral load and survival time in HIV-1 infection

Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.

Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...

Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

Shin, Hyoung Doo, Winkler, Cheryl, Stephens, J. Claiborne, Bream, Jay, Young, Howard, Goedert, James J., ...

IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of...

Modulating influence on HIV/AIDS by interacting RANTES gene variants

An, Ping, Nelson, George W., Wang, Lihua, Donfield, Sharyne, Goedert, James J., Phair, John, ...

RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro. We tested the influence of four RANTES...

HLA-Cw*04 and Hepatitis C Virus Persistence

Thio, Chloe L., Gao, Xiaojiang, Goedert, James J., Vlahov, David, Nelson, Kenrad E., Hilgartner, Margaret W., ...

In studies of acute hepatitis C virus (HCV) infection, the early host immune response is one of the determinants of viral persistence. The class I human leukocyte antigens (HLA), which present...

Quantitation of Human Immunodeficiency Virus Type 1 DNA Forms with the Second Template Switch in Peripheral Blood Cells Predicts Disease Progression Independently of Plasma RNA Load

Kostrikis, Leondios G., Touloumi, Giota, Karanicolas, Rose, Pantazis, Nikos, Anastassopoulou, Cleo, Karafoulidou, Anastasia, ...

There are several forms of human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood T cells and lymph nodes in untreated HIV-1-infected individuals and in patients whose plasma HIV-1 RNA...

Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes

Jin, Xia, Gao, Xiaojiang, Deschenes, Geoffrey R., Nelson, George W., O'Brien, Stephen J., ...

Human immunodeficiency virus type 1 (HIV-1)-infected individuals with HLA-B*35 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3501 (B*35-PY). The...

Distribution of Chemokine Receptor CCR2 and CCR5 Genotypes and Their Relative Contribution to Human Immunodeficiency Virus Type 1 (HIV-1) Seroconversion, Early HIV-1 RNA Concentration in Plasma, and Later Disease Progression

Tang, Jianming, Shelton, Brent, Makhatadze, Nina J., Zhang, Yuting, Schaen, Margaret, Louie, Leslie G., ...

At the CC (β) chemokine receptor 2 (CCR2) and CCR5 loci, combinations of common single-nucleotide polymorphisms (SNPs) and a 32-bp deletion (Δ32) form nine stable haplotypes (designated A through...

Comprehensive Analysis of Class I and Class II HLA Antigens and Chronic Hepatitis B Virus Infection

Thio, Chloe L., Thomas, David L., Karacki, Peter, Gao, Xiaojiang, Marti, Darlene, Kaslow, Richard A., ...

Following an acute hepatitis B virus (HBV) infection, clearance or persistence is determined in part by the vigor and breadth of the host immune response. Since the human leukocyte antigen system...

APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS†

An, Ping, Bleiber, Gabriela, Duggal, Priya, Nelson, George, May, Margaret, Mangeat, Bastien, ...

The cytosine deaminase APOBEC3G, in the absence of the human immunodeficiency virus type 1 (HIV-1) accessory gene HIV-1 viral infectivity factor (vif), inhibits viral replication by introducing G→A...

Association of DC-SIGN Promoter Polymorphism with Increased Risk for Parenteral, but Not Mucosal, Acquisition of Human Immunodeficiency Virus Type 1 Infection

Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...

A High-Density Admixture Map for Disease Gene Discovery in African Americans

Smith, Michael W., Patterson, Nick, Lautenberger, James A., Truelove, Ann L., McDonald, Gavin J., Waliszewska, Alicja, ...

Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans,...

Consistent Effects of TSG101 Genetic Variability on Multiple Outcomes of Exposure to Human Immunodeficiency Virus Type 1†

Bashirova, Arman A., Bleiber, Gabriela, Qi, Ying, Hutcheson, Holli, Yamashita, Traci, Johnson, Randall C., ...

Tumor susceptibility gene 101 (TSG101) encodes a host cellular protein that is appropriated by human immunodeficiency virus type 1 (HIV-1) in the budding process of viral particles from infected...

KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections

Qi, Ying, Martin, Maureen P, Gao, Xiaojiang, Jacobson, Lisa, Goedert, James J, Buchbinder, Susan, ...

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...

Genetic Variation in the CCL18-CCL3-CCL4 Chemokine Gene Cluster Influences HIV Type 1 Transmission and AIDS Disease Progression

Modi, William S., Lautenberger, James, An, Ping, Scott, Kevin, Goedert, James J., Kirk, Gregory D., ...

CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL18 (DC-CK1/PARC/AMAC-1) are potent chemoattractants produced by macrophages, natural killer cells, fibroblasts, mast cells, CD4+ T cells, and CD8+ T cells. CCL3...

Real-Time PCR Assay for Detection and Quantification of Hepatitis B Virus Genotypes A to G

Welzel, Tania M., Miley, Wendell J., Parks, Thomas L., Goedert, James J., Whitby, Denise, Ortiz-Conde, Betty A.

The detection and quantification of hepatitis B virus (HBV) DNA play an important role in diagnosing and monitoring HBV infection as well as assessing therapeutic response. The great variability...

Polymorphisms of CUL5 Are Associated with CD4+ T Cell Loss in HIV-1 Infected Individuals

An, Ping, Duggal, Priya, Wang, Li Hua, O'Brien, Stephen J, Donfield, Sharyne, Goedert, James J, ...

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1....

Genetic Protection against Hepatitis B Virus Conferred by CCR5Δ32: Evidence that CCR5 Contributes to Viral Persistence▿

Thio, Chloe L., Astemborski, Jacquie, Bashirova, Arman, Mosbruger, Timothy, Greer, Spencer, Witt, Mallory D., ...

Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test the hypothesis that...

Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia

Zhang, Mingdong, Rosenberg, Philip S., Brown, Deborah L., Preiss, Liliana, Konkle, Barbara A., Eyster, M. Elaine, ...

People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of...

Regulatory Polymorphisms in the Cyclophilin A Gene, PPIA, Accelerate Progression to AIDS

An, Ping, Wang, Li Hua, Hutcheson-Dilks, Holli, Nelson, George, Donfield, Sharyne, Goedert, James J, ...

Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus...

Polymorphic Admixture Typing in Human Ethnic Populations

Dean, Michael, Stephens, J. Claiborne, Winkler, Cheryl, Lomb, Deborah A., Ramsburg, Mark, Boaze, Raleigh, ...

A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome. Probes from each locus were used in a Southern...

Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS

Biggar, Robert J., Jaffe, Elaine S., Goedert, James J., Chaturvedi, Anil, Pfeiffer, Ruth, Engels, Eric A.

In persons with HIV/AIDS (PWHAs), Hodgkin lymphoma (HL) risk is increased. However, HL incidence in PWHAs has unexpectedly increased since highly active antiretroviral therapy (HAART) was introduced....

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt1

Mbulaiteye, Sam M., Pfeiffer, Ruth M., Dolan, Bryan, Tsang, Victor C.W., Noh, John, Mikhail, Nabiel N.H., ...

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt, Salivary and nosocomial transmission are possible.