Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...
Detection in Fecal DNA of Colon CancerSpecific Methylation of the Nonexpressed Vimentin Gene (2005)
Chen, Wei-Dong, Han, Z. James, Skoletsky, Joel, Olson, Jeff, Sah, Jerome, Myeroff, Lois, ...
Background: Increased DNA methylation is an epigenetic alteration that is common in human cancers and is often associated with transcriptional silencing. Aberrantly methylated DNA has also been...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2003)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2003)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
HLTF gene silencing in human colon cancer. (2002)
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Prevalence of somatic alterations in the colorectal cancer cell genome. (2002)
Wang, Tian-Li, Rago, Carlo, Silliman, Natalie, Ptak, Janine, Markowitz, Sanford, Willson, James K. V., ...
Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2001)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2001)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Mechanisms underlying losses of heterozygosity in human colorectal cancers. (2001)
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5' CpG island of hMLH1 is...
Howell, Gillian M., Humphrey, Lisa E., Ziober, Barry L., Awwad, Rana, Periyasamy, Basker, Koterba, Alan, ...
Aberrant transcriptional regulation of transforming growth factor alpha (TGF alpha) appears to be an important contributor to the malignant phenotype and the growth factor independence with which...
Haut, Mitchell, Steeg, Patricia S., Willson, James K. V., Markowitz, Sanford D.
Levels of expression of the murine nm23 gene inversely correlate with metastatic potential in several rodent tumor model systems. Expression of the human nm23 homologue also is lower in human breast...
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is...
Mechanisms underlying losses of heterozygosity in human colorectal cancers
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
Regulation of Transforming Growth Factor α Expression in a Growth Factor-Independent Cell Line
Howell, Gillian M., Humphrey, Lisa E., Ziober, Barry L., Awwad, Rana, Periyasamy, Basker, Koterba, Alan, ...
Aberrant transcriptional regulation of transforming growth factor α (TGFα) appears to be an important contributor to the malignant phenotype and the growth factor independence with which malignancy...
Prevalence of somatic alterations in the colorectal cancer cell genome
Wang, Tian-Li, Rago, Carlo, Silliman, Natalie, Ptak, Janine, Markowitz, Sanford, Willson, James K. V., ...
Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is...
Mechanisms underlying losses of heterozygosity in human colorectal cancers
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
Regulation of Transforming Growth Factor α Expression in a Growth Factor-Independent Cell Line
Howell, Gillian M., Humphrey, Lisa E., Ziober, Barry L., Awwad, Rana, Periyasamy, Basker, Koterba, Alan, ...
Aberrant transcriptional regulation of transforming growth factor α (TGFα) appears to be an important contributor to the malignant phenotype and the growth factor independence with which malignancy...
Prevalence of somatic alterations in the colorectal cancer cell genome
Wang, Tian-Li, Rago, Carlo, Silliman, Natalie, Ptak, Janine, Markowitz, Sanford, Willson, James K. V., ...
Although a small fraction of human cancers have increased rates of somatic mutation because of known deficiencies in DNA repair, little is known about the prevalence of somatic alterations in the...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...