Anatoly L. Mayburd, Daniel Sackett, Huaitian Liu, Joanna Shih, Jordy Tauler, Ingalill Avis, ...
Abstract The small molecular inhibitor MK886 is known to block 5-lipoxygenase-activating protein ALOX5AP and shows antitumor activity in multiple human cell lines. The broad antitumor therapeutic...
Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer (2008)
Jordi Tauler, James L. Mulshine
Lung cancer is the leading cause of cancer death in the United States and five-year survival remains low. Numerous studies have shown that chronic inflammation may lead to progression of...
Mayburd, Anatoly L., Golovchikova, Inna, Mulshine, James L.
Motivation: New efforts to guide and prioritize the selection of cancer drug targets are urgently needed, as is evident by the slow development of novel anti-cancer agents and the narrow therapeutic...
Kelley, Michael J., Nakagawa, Kazuhiko, Steinberg, Seth M., Mulshine, James L., Kamb, Alexander, Johnson, Bruce E.
Background: The CDKN2 gene encodes the human cyclin-dependent kinase 4 inhibitor. This inhibitor protein is believed to be a tumor suppressor that plays an essential role in cell cycle regulation....
MDR1 Gene Expression in Lung Cancer (1989)
Lai, Shinn-Liang, Goldstein, Lori J., Gottesman, Michael M., Pastan, Ira, Tsai, Chun-Ming, Johnson, Bruce E., ...
The MDR1 gene (also known as PGY1) is frequently overexpressed in multidrug-resistant cell lines. We investigated the role of MDR1 gene expression in lung cancer by performing RNA slot blot analysis...
Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer
Tauler, Jordi, Mulshine, James L.
Lung cancer is the leading cause of cancer death in the United States and five-year survival remains low. Numerous studies have shown that chronic inflammation may lead to progression of...