Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
No abstract available.
Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
No abstract available.
Metzner, Karin J, Binley, James M, Gettie, Agegnehu, Marx, Preston, Nixon, Douglas F, Connor, Ruth I
Abstract Background Emergence of drug-resistant strains of human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful antiretroviral therapy (ART) in HIV-infected patients. Whether...
Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
Abstract During natural HIV infection, an array of host receptors are thought to influence virus attachment and the kinetics of infection. In this study, to probe the interactions of HIV envelope...
Hosie, Margaret J., Klein, Dieter, Binley, James M., Dunsford, Thomas H., Jarrett, Oswald, Neil, James C., ...
An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein,...
Trkola, Alexandra, Ketas, Tom, KewalRamani, Vineet N., Endorf, Fred, Binley, James M., Katinger, Hermann, ...
We have investigated whether the identity of the coreceptor (CCR5, CXCR4, or both) used by primary human immunodeficiency virus type 1 (HIV-1) isolates to enter CD4+ cells influences the sensitivity...
Lacasse, Rachel A., Follis, Kathryn E., Moudgil, Tarsem, Trahey, Meg, Binley, James M., Planelles, Vicente, ...
We have examined the relationship between coreceptor utilization and sensitivity to neutralization in a primary isolate of human immunodeficiency virus type 1 and its T-cell line-adapted (TCLA)...
Binley, James M., Jin, Xia, Huang, Yaoxing, Zhang, Linqi, Cao, Yunzhen, Ho, David D., ...
Long-term nonprogressor AD-18 has been infected with human immunodeficiency virus type 1 (HIV-1) for at least 16 years. During the past 5 years, he has had undetectable levels of plasma viremia, and...
Connor, Ruth I., Montefiori, David C., Binley, James M., Moore, John P., Bonhoeffer, Sebastian, Gettie, Agegnehu, ...
Despite evidence that live, attenuated simian immunodeficiency virus (SIV) vaccines can elicit potent protection against pathogenic SIV infection, detailed information on the replication kinetics of...
Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1
Wang, Meng, Trkola, Alexandra, Binley, James M., Purtscher, Martin, Katinger, Hermann, ...
Although typical primary isolates of human immunodeficiency virus type 1 (HIV-1) are relatively neutralization resistant, three human monoclonal antibodies and a small number of HIV-1+ human sera...
Sanders, Rogier W., Schiffner, Linnea, Master, Aditi, Kajumo, Francis, Guo, Yong, Dragic, Tatjana, ...
We have described an oligomeric gp140 envelope glycoprotein from human immunodeficiency virus type 1 that is stabilized by an intermolecular disulfide bond between gp120 and the gp41 ectodomain,...
Binley, James M., Sanders, Rogier W., Clas, Brian, Schuelke, Norbert, Master, Aditi, Guo, Yong, ...
The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious virions. These native...
Zwick, Michael B., Labrijn, Aran F., Wang, Meng, Spenlehauer, Catherine, Saphire, Erica Ollmann, Binley, James M., ...
The identification and epitope mapping of broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies (Abs) is important for vaccine design, but, despite much effort, very few...
Parker, Carol E., Deterding, Leesa J., Hager-Braun, Christine, Binley, James M., Schülke, Norbert, Katinger, Hermann, ...
Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), in combination with proteolytic protection assays, has been used to identify the functional epitope on human immunodeficiency...
Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., ...
HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that...
Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
Binley, James M., Sanders, Rogier W., Master, Aditi, Cayanan, Charmagne S., Wiley, Cheryl L., Schiffner, Linnea, ...
In virus-infected cells, the envelope glycoprotein (Env) precursor, gp160, of human immunodeficiency virus type 1 is cleaved by cellular proteases into a fusion-competent gp120-gp41 heterodimer in...
Schülke, Norbert, Vesanen, Mika S., Sanders, Rogier W., Zhu, Ping, Lu, Min, Anselma, Deborah J., ...
We describe the further properties of a protein, designated SOS gp140, wherein the association of the gp120 and gp41 subunits of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein...
Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 Pseudovirions
Binley, James M., Cayanan, Charmagne S., Wiley, Cheryl, Schülke, Norbert, Olson, William C., Burton, Dennis R.
We previously described a human immunodeficiency virus type 1 (HIV-1) envelope mutant that introduces a disulfide bridge between the gp120 surface proteins and gp41 transmembrane proteins (J. M....
Binley, James M., Wrin, Terri, Korber, Bette, Zwick, Michael B., Wang, Meng, Chappey, Colombe, ...
Broadly neutralizing monoclonal antibodies (MAbs) are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design. A few rare MAbs have been intensively studied, but we...
Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1
Moore, Penny L., Crooks, Emma T., Porter, Lauren, Zhu, Ping, Cayanan, Charmagne S., Grise, Henry, ...
Human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies are thought be distinguished from nonneutralizing antibodies by their ability to recognize functional gp120/gp41 envelope...
Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
During natural HIV infection, an array of host receptors are thought to influence virus attachment and the kinetics of infection. In this study, to probe the interactions of HIV envelope (Env) with...
Hosie, Margaret J., Klein, Dieter, Binley, James M., Dunsford, Thomas H., Jarrett, Oswald, Neil, James C., ...
An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein,...
Trkola, Alexandra, Ketas, Tom, KewalRamani, Vineet N., Endorf, Fred, Binley, James M., Katinger, Hermann, ...
We have investigated whether the identity of the coreceptor (CCR5, CXCR4, or both) used by primary human immunodeficiency virus type 1 (HIV-1) isolates to enter CD4+ cells influences the sensitivity...
Lacasse, Rachel A., Follis, Kathryn E., Moudgil, Tarsem, Trahey, Meg, Binley, James M., Planelles, Vicente, ...
We have examined the relationship between coreceptor utilization and sensitivity to neutralization in a primary isolate of human immunodeficiency virus type 1 and its T-cell line-adapted (TCLA)...
Binley, James M., Jin, Xia, Huang, Yaoxing, Zhang, Linqi, Cao, Yunzhen, Ho, David D., ...
Long-term nonprogressor AD-18 has been infected with human immunodeficiency virus type 1 (HIV-1) for at least 16 years. During the past 5 years, he has had undetectable levels of plasma viremia, and...
Connor, Ruth I., Montefiori, David C., Binley, James M., Moore, John P., Bonhoeffer, Sebastian, Gettie, Agegnehu, ...
Despite evidence that live, attenuated simian immunodeficiency virus (SIV) vaccines can elicit potent protection against pathogenic SIV infection, detailed information on the replication kinetics of...
Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1
Wang, Meng, Trkola, Alexandra, Binley, James M., Purtscher, Martin, Katinger, Hermann, ...
Although typical primary isolates of human immunodeficiency virus type 1 (HIV-1) are relatively neutralization resistant, three human monoclonal antibodies and a small number of HIV-1+ human sera...
Sanders, Rogier W., Schiffner, Linnea, Master, Aditi, Kajumo, Francis, Guo, Yong, Dragic, Tatjana, ...
We have described an oligomeric gp140 envelope glycoprotein from human immunodeficiency virus type 1 that is stabilized by an intermolecular disulfide bond between gp120 and the gp41 ectodomain,...
Binley, James M., Sanders, Rogier W., Clas, Brian, Schuelke, Norbert, Master, Aditi, Guo, Yong, ...
The few antibodies that can potently neutralize human immunodeficiency virus type 1 (HIV-1) recognize the limited number of envelope glycoprotein epitopes exposed on infectious virions. These native...
Zwick, Michael B., Labrijn, Aran F., Wang, Meng, Spenlehauer, Catherine, Saphire, Erica Ollmann, Binley, James M., ...
The identification and epitope mapping of broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies (Abs) is important for vaccine design, but, despite much effort, very few...
Parker, Carol E., Deterding, Leesa J., Hager-Braun, Christine, Binley, James M., Schülke, Norbert, Katinger, Hermann, ...
Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), in combination with proteolytic protection assays, has been used to identify the functional epitope on human immunodeficiency...
Moulard, Maxime, Phogat, Sanjay K., Shu, Yuuei, Labrijn, Aran F., Xiao, Xiaodong, Binley, James M., ...
HIV-1 entry into cells involves formation of a complex between gp120 of the viral envelope glycoprotein (Env), a receptor (CD4), and a coreceptor, typically CCR5. Here we provide evidence that...
Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
Binley, James M., Sanders, Rogier W., Master, Aditi, Cayanan, Charmagne S., Wiley, Cheryl L., Schiffner, Linnea, ...
In virus-infected cells, the envelope glycoprotein (Env) precursor, gp160, of human immunodeficiency virus type 1 is cleaved by cellular proteases into a fusion-competent gp120-gp41 heterodimer in...
Schülke, Norbert, Vesanen, Mika S., Sanders, Rogier W., Zhu, Ping, Lu, Min, Anselma, Deborah J., ...
We describe the further properties of a protein, designated SOS gp140, wherein the association of the gp120 and gp41 subunits of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein...
Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 Pseudovirions
Binley, James M., Cayanan, Charmagne S., Wiley, Cheryl, Schülke, Norbert, Olson, William C., Burton, Dennis R.
We previously described a human immunodeficiency virus type 1 (HIV-1) envelope mutant that introduces a disulfide bridge between the gp120 surface proteins and gp41 transmembrane proteins (J. M....
Binley, James M., Wrin, Terri, Korber, Bette, Zwick, Michael B., Wang, Meng, Chappey, Colombe, ...
Broadly neutralizing monoclonal antibodies (MAbs) are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design. A few rare MAbs have been intensively studied, but we...
Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1
Moore, Penny L., Crooks, Emma T., Porter, Lauren, Zhu, Ping, Cayanan, Charmagne S., Grise, Henry, ...
Human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies are thought be distinguished from nonneutralizing antibodies by their ability to recognize functional gp120/gp41 envelope...
Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
During natural HIV infection, an array of host receptors are thought to influence virus attachment and the kinetics of infection. In this study, to probe the interactions of HIV envelope (Env) with...
Derby, Nina R., Kraft, Zane, Kan, Elaine, Crooks, Emma T., Barnett, Susan W., Srivastava, Indresh K., ...
The antibody responses elicited in rhesus macaques immunized with soluble human immunodeficiency virus (HIV) Env gp140 proteins derived from the R5-tropic HIV-1 SF162 virus were analyzed and compared...
Metzner, Karin J, Binley, James M, Gettie, Agegnehu, Marx, Preston, Nixon, Douglas F, Connor, Ruth I
Hosie, Margaret J., Klein, Dieter, Binley, James M., Dunsford, Thomas H., Jarrett, Oswald, Neil, James C., ...
An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein,...
Binley, James M, Ngo-Abdalla, Stacie, Moore, Penny, Bobardt, Michael, Chatterji, Udayan, Gallay, Philippe, ...
Derby, Nina R., Kraft, Zane, Kan, Elaine, Crooks, Emma T., Barnett, Susan W., Srivastava, Indresh K., ...
Nelson, Josh D., Brunel, Florence M., Jensen, Richard, Crooks, Emma T., Cardoso, Rosa M. F., Wang, Meng, ...
The membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 bears the epitopes of two broadly neutralizing antibodies (Abs), 2F5 and 4E10, making it a target for...
Morris, Lynn, Binley, James M., Clas, Brian A., Bonhoeffer, Sebastian, Astill, Thomas P., Kost, Rhonda, ...
We studied how combination antiviral therapy affects B cell abnormalities associated with HIV-1 infection, namely elevated circulating immunoglobulin (Ig)G antibody-secreting cell (ASC) frequencies...
Binley, James M., Lybarger, Elizabeth A., Crooks, Emma T., Seaman, Michael S., Gray, Elin, Davis, Katie L., ...
Identifying the viral epitopes targeted by broad neutralizing antibodies (NAbs) that sometimes develop in human immunodeficiency virus type 1 (HIV-1)-infected subjects should assist in the design of...