Huntington, Nicholas D., Labi, Verena, Cumano, Ana, Vieira, Paulo, Strasser, Andreas, Villunger, Andreas, ...
IL-7 is pivotal for B cell development. Proteins of the Bcl-2 family are essential regulators of lymphocyte survival. Particularly, the pro-apoptotic BH3-only members Bim and Puma mediate lymphocyte...
Lochner, Matthias, Peduto, Lucie, Cherrier, Marie, Sawa, Shinichiro, Langa, Francina, Varona, Rosa, ...
The nuclear hormone receptor retinoic acid receptor-related orphan receptor gamma t (RORgamma t) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine...
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. (2003)
Zompi, Simona, Hamerman, Jessica A, Ogasawara, Kouetsu, Schweighoffer, Edina, Tybulewicz, Victor L J, Di Santo, James P, ...
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family...
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases (2003)
Zompi, Simona, Hamerman, Jessica A, Ogasawara, Kouetsu, Schweighoffer, Edina, Tybulewicz, Victor L J, Di Santo, James P, ...
In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family...
Tsujino, Shiho, Di Santo, James P., Takaoka, Akinori, McKernan, Teresa L., Noguchi, Shigeru, Taya, Choji, ...
The common cytokine receptor γ chain (γc), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic...
Gaillot, Olivier, Bregenholt, Søren, Jaubert, Francis, Di Santo, James P., Berche, Patrick
The stress-induced protease ClpP is required for virulence of the facultative intracellular pathogen Listeria monocytogenes. We previously found that in the absence of ClpP, the virulence of this...
IL-15 availability conditions homeostasis of peripheral natural killer T cells
Ranson, Thomas, Vosshenrich, Christian A. J., Corcuff, Erwan, Richard, Odile, Laloux, Veronique, Lehuen, Agnès, ...
Steady-state numbers of peripheral lymphocyte are tightly controlled. For conventional T cells, signals delivered through the interaction of the T cell receptor (TCR) with antigen-loaded MHC...
Role of an Intact Splenic Microarchitecture in Early Lymphocytic Choriomeningitis Virus Production
Müller, Stefan, Hunziker, Lukas, Enzler, Susanne, Bühler-Jungo, Myriam, Di Santo, James P., Zinkernagel, Rolf M., ...
An acute infection with lymphocytic choriomeningitis virus (LCMV) is efficiently controlled by the cytotoxic-T-cell (CTL) response of the host, and LCMV titers in the spleen and peripheral solid...
IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival
Goudeau, Bertrand, Huetz, François, Samson, Sandrine, Di Santo, James P., Cumano, Ana, Beg, Amer, ...
In most cells, the NF-κB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the IκBs. Here, we show that combined IκBα/IκBε deficiency in mice leads...
Vollstedt, Sabine, Arnold, Susi, Schwerdel, Cornelia, Franchini, Marco, Alber, Gottfried, Di Santo, James P., ...
The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be...
Vosshenrich, Christian A. J., Cumano, Ana, Müller, Werner, Di Santo, James P., Vieira, Paulo
IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the...
Tsujino, Shiho, Di Santo, James P., Takaoka, Akinori, McKernan, Teresa L., Noguchi, Shigeru, Taya, Choji, ...
The common cytokine receptor γ chain (γc), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic...
Gaillot, Olivier, Bregenholt, Søren, Jaubert, Francis, Di Santo, James P., Berche, Patrick
The stress-induced protease ClpP is required for virulence of the facultative intracellular pathogen Listeria monocytogenes. We previously found that in the absence of ClpP, the virulence of this...
IL-15 availability conditions homeostasis of peripheral natural killer T cells
Ranson, Thomas, Vosshenrich, Christian A. J., Corcuff, Erwan, Richard, Odile, Laloux, Veronique, Lehuen, Agnès, ...
Steady-state numbers of peripheral lymphocyte are tightly controlled. For conventional T cells, signals delivered through the interaction of the T cell receptor (TCR) with antigen-loaded MHC...
Role of an Intact Splenic Microarchitecture in Early Lymphocytic Choriomeningitis Virus Production
Müller, Stefan, Hunziker, Lukas, Enzler, Susanne, Bühler-Jungo, Myriam, Di Santo, James P., Zinkernagel, Rolf M., ...
An acute infection with lymphocytic choriomeningitis virus (LCMV) is efficiently controlled by the cytotoxic-T-cell (CTL) response of the host, and LCMV titers in the spleen and peripheral solid...
IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival
Goudeau, Bertrand, Huetz, François, Samson, Sandrine, Di Santo, James P., Cumano, Ana, Beg, Amer, ...
In most cells, the NF-κB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the IκBs. Here, we show that combined IκBα/IκBε deficiency in mice leads...
Vollstedt, Sabine, Arnold, Susi, Schwerdel, Cornelia, Franchini, Marco, Alber, Gottfried, Di Santo, James P., ...
The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be...
Vosshenrich, Christian A. J., Cumano, Ana, Müller, Werner, Di Santo, James P., Vieira, Paulo
IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the...
γc cytokines condition the progressive differentiation of CD4+ T cells
Masse, Guillemette X., Corcuff, Erwan, Strick-Marchand, Hélène, Guy-Grand, Delphine, Tafuri-Bladt, Anna, Albert, Matthew L., ...
After their initial antigen encounter in the secondary lymphoid organs, activated T cells must receive additional signals in the peripheral tissues to fully differentiate. Here, we provide evidence...
Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?
Grandjean, Isabelle, Duban, Livine, Bonney, Elizabeth A., Corcuff, Erwan, Di Santo, James P., Matzinger, Polly, ...
The exact role of major histocompatibility complex (MHC) molecules in the peripheral survival of naive T cells is controversial, as some studies have suggested that they are critically required...
Di Santo, James P., Aifantis, Iannis, Rosmaraki, Eleftheria, Garcia, Corinne, Feinberg, Jacqueline, Fehling, Hans Jörg, ...
Intracellular signals emanating from cytokine and antigen receptors are integrated during the process of intrathymic development. Still, the relative contributions of cytokine receptor signaling to...
Ashkar, Ali A., Di Santo, James P., Croy, B. Anne
The dominant lymphocytes in human and murine implantation sites are transient, pregnancy-associated uterine natural killer (uNK) cells. These cells are a major source of interferon (IFN)-γ....
Park, Linda S., Martin, Unja, Garka, Kirsten, Gliniak, Brian, Di Santo, James P., Muller, Werner, ...
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the...
Functional Dichotomy in Natural Killer Cell Signaling: Vav1-Dependent and -Independent Mechanisms
Colucci, Francesco, Rosmaraki, Eleftheria, Bregenholt, Søren, Samson, Sandrine I., Di Bartolo, Vincenzo, Turner, Martin, ...
The product of the protooncogene Vav1 participates in multiple signaling pathways and is a critical regulator of antigen–receptor signaling in B and T lymphocytes, but its role during in vivo...
Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
Aifantis, Iannis, Feinberg, Jacqueline, Fehling, Hans Jörg, Di Santo, James P., Von Boehmer, Harald
We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25+44− thymocytes by mechanisms that are...
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells
Vosshenrich, Christian A.J., Lesjean-Pottier, Sarah, Hasan, Milena, Corcuff, Erwan, Mandelboim, Ofer, ...
Interferon-producing killer dendritic cells (IKDCs) are a recently described subset of CD11cloB220+ cells that share phenotypic and functional properties of DCs and natural killer (NK) cells (Chan,...
Morgan, Jennifer E., Gross, Jacqueline G., Pagel, Charles N., Beauchamp, Jonathan R., Fassati, Ariberto, Thrasher, Adrian J., ...
Environmental influences have profound yet reversible effects on the behavior of resident cells. Earlier data have indicated that the amount of muscle formed from implanted myogenic cells is greatly...
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
Huntington, Nicholas D., Legrand, Nicolas, Alves, Nuno L., Jaron, Barbara, Weijer, Kees, Plet, Ariane, ...
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing inhibitory receptors for self–major histocompatability complex class...
Characterization of the thymic IL-7 niche in vivo
Alves, Nuno L., Goff, Odile Richard-Le, Huntington, Nicholas D., Sousa, Ana Patricia, Ribeiro, Vera S. G., Bordack, Allison, ...
The thymus represents the “cradle” for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although IL-7 is recognized as an essential...