Hu, Guanggan, Liu, Iris, Sham, Anita, Stajich, Jason E, Dietrich, Fred S, Kronstad, James W
Abstract Background Genome variability can have a profound influence on the virulence of pathogenic microbes. The availability of genome sequences for two strains of the AIDS-associated fungal...
Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans (2008)
Won Hee Jung, Anita Sham, Tianshun Lian, Arvinder Singh, Daniel J. Kosman, James W. Kronstad
The level of available iron in the mammalian host is extremely low, and pathogenic microbes must compete with host proteins such as transferrin for iron. Iron regulation of gene expression, including...
Transcriptional Regulation by Protein Kinase A in Cryptococcus neoformans (2007)
Guanggan Hu, Barbara R. Steen, Tianshun Lian, Anita P. Sham, Nicola Tam, Kristin L. Tangen, ...
A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in...
Won Hee Jung, Anita Sham, Rick White, James W. Kronstad
Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus...
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis (2006)
Kahmann, Regine, Bölker, Michael, Ma, Li-Jun, Brefort, Thomas, Saville, Barry J, ...
Ustilago maydis is a ubiquitous pathogen of maize and a well-established model organism for the study of plant-microbe interactions. This basidiomycete fungus does not use aggressive virulence...
Physical map-assisted whole-genome shotgun sequence assemblies (2006)
Warren, René L., Varabei, Dmitry, Platt, Darren, Huang, Xiaoqiu, Messina, David, Yang, Shiaw-Pyng, ...
We describe a targeted approach to improve the contiguity of whole-genome shotgun sequence (WGS) assemblies at run-time, using information from Bacterial Artificial Chromosome (BAC)-based physical...
Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna L., Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
Temperature-Regulated Transcription in the Pathogenic Fungus Cryptococcus neoformans (2002)
Steen, Barbara R., Lian, Tian, Zuyderduyn, Scott, MacDonald, William Kim, Marra, Marco, Jones, Steven J.M., ...
Schein, Jacqueline E., Tangen, Kristin L., Chiu, Readman, Shin, Heesun, Lengeler, Klaus B., MacDonald, William Kim, ...
Schein, Jacqueline E., Tangen, Kristin L., Chiu, Readman, Shin, Heesun, Lengeler, Klaus B., MacDonald, William Kim, ...
Dürrenberger, Franz, Wong, Katherine, Kronstad, James W.
Ustilago maydis, a fungal pathogen of maize, alternates between budding and filamentous growth in response to mating and other environmental signals. Defects in components of the cAMP signaling...
The mating-type and pathogenicity locus of the fungus Ustilago hordei spans a 500-kb region
Lee, Nancy, Bakkeren, Guus, Wong, Katherine, Sherwood, John E., Kronstad, James W.
The fungal pathogen Ustilago hordei causes the covered smut disease of barley and oats. Mating and pathogenicity in this fungus are controlled by the MAT locus, which contains two distinct gene...
Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna, Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
Lee, Nancy, Kronstad, James W.
Ustilago maydis, a pathogen of maize, is a useful model for the analysis of mating, pathogenicity, and the morphological transition between budding and filamentous growth in fungi. As in other fungi,...
Temperature-Regulated Transcription in the Pathogenic Fungus Cryptococcus neoformans
Steen, Barbara R., Lian, Tian, Zuyderduyn, Scott, MacDonald, William Kim, Marra, Marco, Jones, Steven J.M., ...
The basidiomycete fungus Cryptococcus neoformans is an opportunistic pathogen of worldwide importance that causes meningitis, leading to death in immunocompromised individuals. Unlike many...
Schein, Jacqueline E., Tangen, Kristin L., Chiu, Readman, Shin, Heesun, Lengeler, Klaus B., MacDonald, William Kim, ...
The basidiomycete fungus Cryptococcus neoformans is an important opportunistic pathogen of humans that poses a significant threat to immunocompromised individuals. Isolates of C. neoformans are...
Kidd, Sarah E., Guo, Hong, Bartlett, Karen H., Xu, Jianping, Kronstad, James W.
Cryptococcus gattii has recently emerged as a pathogen of humans and animals in the temperate climate of Vancouver Island, British Columbia (B.C.). The majority (∼95%) of the isolates from the...
Larraya, Luis M., Boyce, Kylie J., So, Austin, Steen, Barbara R., Jones, Steven, Marra, Marco, ...
The switch from budding to filamentous growth is a key aspect of invasive growth and virulence for the fungal phytopathogen Ustilago maydis. The cyclic AMP (cAMP) signaling pathway regulates...
Boyce, Kylie J., Chang, Howard, D'Souza, Cletus A., Kronstad, James W.
During maize infection, the fungal pathogen Ustilago maydis undergoes a dimorphic transition from budding, yeast-like cells to a filamentous dikaryon that proliferates in the host. This transition is...
Physical map-assisted whole-genome shotgun sequence assemblies
Warren, René L., Varabei, Dmitry, Platt, Darren, Huang, Xiaoqiu, Messina, David, Yang, Shiaw-Pyng, ...
We describe a targeted approach to improve the contiguity of whole-genome shotgun sequence (WGS) assemblies at run-time, using information from Bacterial Artificial Chromosome (BAC)-based physical...
Boyce, Kylie J., Kretschmer, Matthias, Kronstad, James W.
The maize pathogen Ustilago maydis switches from budding to filamentous, dikaryotic growth in response to environmental signals including nutrient status, growth in the host, and the presence of...
Dürrenberger, Franz, Wong, Katherine, Kronstad, James W.
Ustilago maydis, a fungal pathogen of maize, alternates between budding and filamentous growth in response to mating and other environmental signals. Defects in components of the cAMP signaling...
The mating-type and pathogenicity locus of the fungus Ustilago hordei spans a 500-kb region
Lee, Nancy, Bakkeren, Guus, Wong, Katherine, Sherwood, John E., Kronstad, James W.
The fungal pathogen Ustilago hordei causes the covered smut disease of barley and oats. Mating and pathogenicity in this fungus are controlled by the MAT locus, which contains two distinct gene...
Alspaugh, J. Andrew, Pukkila-Worley, Read, Harashima, Toshiaki, Cavallo, Lora M., Funnell, Deanna, Cox, Gary M., ...
The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is...
Lee, Nancy, Kronstad, James W.
Ustilago maydis, a pathogen of maize, is a useful model for the analysis of mating, pathogenicity, and the morphological transition between budding and filamentous growth in fungi. As in other fungi,...
Temperature-Regulated Transcription in the Pathogenic Fungus Cryptococcus neoformans
Steen, Barbara R., Lian, Tian, Zuyderduyn, Scott, MacDonald, William Kim, Marra, Marco, Jones, Steven J.M., ...
The basidiomycete fungus Cryptococcus neoformans is an opportunistic pathogen of worldwide importance that causes meningitis, leading to death in immunocompromised individuals. Unlike many...
Schein, Jacqueline E., Tangen, Kristin L., Chiu, Readman, Shin, Heesun, Lengeler, Klaus B., MacDonald, William Kim, ...
The basidiomycete fungus Cryptococcus neoformans is an important opportunistic pathogen of humans that poses a significant threat to immunocompromised individuals. Isolates of C. neoformans are...
Kidd, Sarah E., Guo, Hong, Bartlett, Karen H., Xu, Jianping, Kronstad, James W.
Cryptococcus gattii has recently emerged as a pathogen of humans and animals in the temperate climate of Vancouver Island, British Columbia (B.C.). The majority (∼95%) of the isolates from the...
Larraya, Luis M., Boyce, Kylie J., So, Austin, Steen, Barbara R., Jones, Steven, Marra, Marco, ...
The switch from budding to filamentous growth is a key aspect of invasive growth and virulence for the fungal phytopathogen Ustilago maydis. The cyclic AMP (cAMP) signaling pathway regulates...
Boyce, Kylie J., Chang, Howard, D'Souza, Cletus A., Kronstad, James W.
During maize infection, the fungal pathogen Ustilago maydis undergoes a dimorphic transition from budding, yeast-like cells to a filamentous dikaryon that proliferates in the host. This transition is...
Physical map-assisted whole-genome shotgun sequence assemblies
Warren, René L., Varabei, Dmitry, Platt, Darren, Huang, Xiaoqiu, Messina, David, Yang, Shiaw-Pyng, ...
We describe a targeted approach to improve the contiguity of whole-genome shotgun sequence (WGS) assemblies at run-time, using information from Bacterial Artificial Chromosome (BAC)-based physical...
Boyce, Kylie J., Kretschmer, Matthias, Kronstad, James W.
The maize pathogen Ustilago maydis switches from budding to filamentous, dikaryotic growth in response to environmental signals including nutrient status, growth in the host, and the presence of...
Jung, Won Hee, Sham, Anita, White, Rick, Kronstad, James W
Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus...
Transcriptional Regulation by Protein Kinase A in Cryptococcus neoformans
Hu, Guanggan, Steen, Barbara R, Lian, Tianshun, Sham, Anita P, Tam, Nicola, Tangen, Kristin L, ...
A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in...
Klose, Jana, Kronstad, James W.
The transition from yeast-like to filamentous growth in the biotrophic fungal phytopathogen Ustilago maydis is a crucial event for pathogenesis. Previously, we showed that fatty acids induce...
Kidd, Sarah E., Chow, Yat, Mak, Sunny, Bach, Paxton J., Chen, Huiming, Hingston, Adrian O., ...
Cryptococcus gattii has recently emerged as a primary pathogen of humans and wild and domesticated animals in British Columbia, particularly on Vancouver Island. C. gattii infections are typically...
Role of Homoserine Transacetylase as a New Target for Antifungal Agents▿
Nazi, Ishac, Scott, Adam, Sham, Anita, Rossi, Laura, Williamson, Peter R., Kronstad, James W., ...
Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in...
Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans
Jung, Won Hee, Sham, Anita, Lian, Tianshun, Singh, Arvinder, Kosman, Daniel J, Kronstad, James W
The level of available iron in the mammalian host is extremely low, and pathogenic microbes must compete with host proteins such as transferrin for iron. Iron regulation of gene expression, including...
Hu, Guanggan, Liu, Iris, Sham, Anita, Stajich, Jason E, Dietrich, Fred S, Kronstad, James W
Extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans is revealed through comparative genome hybridization between strains of different mating type, molecular subtype and...
Xu, Jun, Saunders, Charles W., Hu, Ping, Grant, Raymond A., Boekhout, Teun, Kuramae, Eiko E., ...
Fungi in the genus Malassezia are ubiquitous skin residents of humans and other warm-blooded animals. Malassezia are involved in disorders including dandruff and seborrheic dermatitis, which together...
Cryptococcus gattii Dispersal Mechanisms, British Columbia, Canada
Kidd, Sarah E., Bach, Paxton J., Hingston, Adrian O., Mak, Sunny, Chow, Yat, MacDougall, Laura, ...
C. gattii may be spread through soil disturbances, wind, water, distribution of tree and soil byproducts, and human movement.
MacDougall, Laura, Kidd, Sarah E., Galanis, Eleni, Mak, Sunny, Leslie, Mira J., Cieslak, Paul R., ...
Cryptococcus gattii, emergent on Vancouver Island, British Columbia (BC), Canada, in 1999, was detected during 2003–2005 in 3 persons and 8 animals that did not travel to Vancouver Island during...