Bärbel Stecher, Riccardo Robbiani, Alan W. Walker, Astrid M. Westendorf, Manja Barthel, Marcus Kremer, ...
Most mucosal surfaces of the mammalian body are colonized by microbial communities (“microbiota”). A high density of commensal microbiota inhabits the intestine and shields from infection...
He, Feng, Buer, Jan, Zeng, An-Ping, Balling, Rudi
Abstract Background The regulation of genes in multicellular organisms is generally achieved through the combinatorial activity of different transcription factors. However, the quantitative...
Gereke, Marcus, Gröbe, Lothar, Prettin, Silvia, Kasper, Michael, Deppenmeier, Stefanie, Gruber, Achim D, ...
Abstract Background Although the contribution of alveolar type II epithelial cell (AEC II) activities in various aspects of respiratory immune regulation has become increasingly appreciated, our...
Identification of novel regulators in T-cell differentiation of aplastic anemia patients (2006)
Franzke, Anke, Geffers, Robert, Hunger, J Katrin, Pförtner, Susanne, Piao, Wenji, Ivanyi, Philipp, ...
Abstract Background Aplastic anemia (AA) is a bone marrow failure syndrome mostly characterized by an immune-mediated destruction of marrow hematopoietic progenitor/stem cells. The resulting...
Signatures of human regulatory T cells: an encounter with old friends and new players (2006)
Pfoertner, Susanne, Jeron, Andreas, Probst-Kepper, Michael, Guzman, Carlos A, Hansen, Wiebke, Westendorf, Astrid M, ...
Abstract Background Naturally occurring CD4 + CD25 + regulatory T cells (T Reg ) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity. Thus far,...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Abstract Background The use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained...
Ma, Hong-Wu, Buer, Jan, Zeng, An-Ping
Abstract Background Cellular functions are coordinately carried out by groups of genes forming functional modules. Identifying such modules in the transcriptional regulatory network (TRN) of...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression (2004)
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Ma, Hong-Wu, Kumar, Bharani, Ditges, Uta, Gunzer, Florian, Buer, Jan, Zeng, An-Ping
Recent studies of genome-wide transcriptional regulatory network (TRN) revealed several intriguing structural and dynamic features of gene expression at a system level. Unfortunately, the network...
Funktionelle Genomanalyse des T-Zell-Immunsystems : Selektion, Überleben und Regulation / (2001)
Enth. ausserdem 7 Sonderabdr. aus verschiedenen Zeitschr.- Beitr. teilw. dt., teilw. engl.
Peripheral Blood Tyrosinase Messenger RNA Detection and Survival in Malignant Melanoma (1996)
Kunter, Uta, Buer, Jan, Probst, Michael, Duensing, Stefan, Dallmann, Iris, Grosse, Jens, ...
Background: The most widely accepted criteria for the evaluation of prognosis of malignant melanoma are histopathologic and clinical presentation. No currently available laboratory tests provide...
Hannover, Med. Hochsch., Diss., 1995.
Pulz, Matthias, Matussek, Andreas, Monazahian, Masyar, Tittel, Andreas, Nikolic, Elisabet, Hartmann, Maike, ...
Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of sporadic cases of disease as well as serious outbreaks worldwide. The spectrum of illnesses includes mild nonbloody diarrhea,...
Von Götz, Franz, Häussler, Susanne, Jordan, Doris, Saravanamuthu, Senthil Selvan, Wehmhöner, Dirk, Strüßmann, André, ...
The heterogeneous environment of the lung of the cystic fibrosis (CF) patient gives rise to Pseudomonas aeruginosa small colony variants (SCVs) with increased antibiotic resistance, autoaggregative...
Eschbach, Martin, Schreiber, Kerstin, Trunk, Katharina, Buer, Jan, Jahn, Dieter, Schobert, Max
Denitrification and arginine fermentation are central metabolic processes performed by the opportunistic pathogen Pseudomonas aeruginosa during biofilm formation and infection of lungs of patients...
Evidence for Polyadenylated mRNA in Pseudomonas aeruginosa
Saravanamuthu, Senthil Selvan, Von Götz, Franz, Salunkhe, Prabhakar, Chozhavendan, Rathinam, Geffers, Robert, Buer, Jan, ...
In this paper, we report the synthesis of Pseudomonas aeruginosa cDNA in the presence of oligo(dT) primers. Hybridization of oligonucleotide DNA microarrays indicates that under the experimental...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Rharbaoui, Faiza, Westendorf, Astrid, Link, Claudia, Felk, Sandra, Buer, Jan, Gunzer, Matthias, ...
A better knowledge on how immune responses are initiated in mucosal tissues would facilitate the design of new mucosal vaccines, as well as improve our understanding on host defense against...
Ma, Hong-Wu, Kumar, Bharani, Ditges, Uta, Gunzer, Florian, Buer, Jan, Zeng, An-Ping
Recent studies of genome-wide transcriptional regulatory network (TRN) revealed several intriguing structural and dynamic features of gene expression at a system level. Unfortunately, the network...
Salunkhe, Prabhakar, Töpfer, Tanja, Buer, Jan, Tümmler, Burkhard
The steady-state response of Pseudomonas aeruginosa to the oxidative-stress-generating agent hydrogen peroxide was analyzed by PAO1 transcriptome profiling. In total, 694, 411, and 237 genes were...
Blumenthal, Antje, Lauber, Jörg, Hoffmann, Reinhard, Ernst, Martin, Keller, Christine, Buer, Jan, ...
Classification of pathogenic species according to the distinct host transcriptional responses that they elicit may become a relevant tool for microarray-based diagnosis of infection. Individual...
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Lechel, André, Satyanarayana, Ande, Ju, Zhenyu, Plentz, Ruben R, Schaetzlein, Sonja, Rudolph, Cornelia, ...
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Nalca, Yusuf, Jänsch, Lothar, Bredenbruch, Florian, Geffers, Robert, Buer, Jan, Häussler, Susanne
The administration of macrolides such as azithromycin for chronic pulmonary infection of cystic fibrosis patients has been reported to be of benefit. Although the mechanisms of action remain obscure,...
Identification of novel regulators in T-cell differentiation of aplastic anemia patients
Franzke, Anke, Geffers, Robert, Hunger, J Katrin, Pförtner, Susanne, Piao, Wenji, Ivanyi, Philipp, ...
Pulz, Matthias, Matussek, Andreas, Monazahian, Masyar, Tittel, Andreas, Nikolic, Elisabet, Hartmann, Maike, ...
Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of sporadic cases of disease as well as serious outbreaks worldwide. The spectrum of illnesses includes mild nonbloody diarrhea,...
Von Götz, Franz, Häussler, Susanne, Jordan, Doris, Saravanamuthu, Senthil Selvan, Wehmhöner, Dirk, Strüßmann, André, ...
The heterogeneous environment of the lung of the cystic fibrosis (CF) patient gives rise to Pseudomonas aeruginosa small colony variants (SCVs) with increased antibiotic resistance, autoaggregative...
Eschbach, Martin, Schreiber, Kerstin, Trunk, Katharina, Buer, Jan, Jahn, Dieter, Schobert, Max
Denitrification and arginine fermentation are central metabolic processes performed by the opportunistic pathogen Pseudomonas aeruginosa during biofilm formation and infection of lungs of patients...
Evidence for Polyadenylated mRNA in Pseudomonas aeruginosa
Saravanamuthu, Senthil Selvan, Von Götz, Franz, Salunkhe, Prabhakar, Chozhavendan, Rathinam, Geffers, Robert, Buer, Jan, ...
In this paper, we report the synthesis of Pseudomonas aeruginosa cDNA in the presence of oligo(dT) primers. Hybridization of oligonucleotide DNA microarrays indicates that under the experimental...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Rharbaoui, Faiza, Westendorf, Astrid, Link, Claudia, Felk, Sandra, Buer, Jan, Gunzer, Matthias, ...
A better knowledge on how immune responses are initiated in mucosal tissues would facilitate the design of new mucosal vaccines, as well as improve our understanding on host defense against...
Ma, Hong-Wu, Kumar, Bharani, Ditges, Uta, Gunzer, Florian, Buer, Jan, Zeng, An-Ping
Recent studies of genome-wide transcriptional regulatory network (TRN) revealed several intriguing structural and dynamic features of gene expression at a system level. Unfortunately, the network...
Salunkhe, Prabhakar, Töpfer, Tanja, Buer, Jan, Tümmler, Burkhard
The steady-state response of Pseudomonas aeruginosa to the oxidative-stress-generating agent hydrogen peroxide was analyzed by PAO1 transcriptome profiling. In total, 694, 411, and 237 genes were...
Blumenthal, Antje, Lauber, Jörg, Hoffmann, Reinhard, Ernst, Martin, Keller, Christine, Buer, Jan, ...
Classification of pathogenic species according to the distinct host transcriptional responses that they elicit may become a relevant tool for microarray-based diagnosis of infection. Individual...
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Lechel, André, Satyanarayana, Ande, Ju, Zhenyu, Plentz, Ruben R, Schaetzlein, Sonja, Rudolph, Cornelia, ...
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Nalca, Yusuf, Jänsch, Lothar, Bredenbruch, Florian, Geffers, Robert, Buer, Jan, Häussler, Susanne
The administration of macrolides such as azithromycin for chronic pulmonary infection of cystic fibrosis patients has been reported to be of benefit. Although the mechanisms of action remain obscure,...
Identification of novel regulators in T-cell differentiation of aplastic anemia patients
Franzke, Anke, Geffers, Robert, Hunger, J Katrin, Pförtner, Susanne, Piao, Wenji, Ivanyi, Philipp, ...
Signatures of human regulatory T cells: an encounter with old friends and new players
Pfoertner, Susanne, Jeron, Andreas, Probst-Kepper, Michael, Guzman, Carlos A, Hansen, Wiebke, Westendorf, Astrid M, ...
Comparison of the gene expression in human T regulatory cells and naïve cells using a T regulatory cell-specific microarray reveals cell-specific gene signatures.
Timmerbeul, Inke, Garrett-Engele, Carrie M., Kossatz, Uta, Chen, Xueyan, Firpo, Eduardo, Grünwald, Viktor, ...
Decreased expression of the CDK inhibitor p27kip1 in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of...
Jablonska, Jadwiga, Dittmar, Kurt E., Kleinke, Tanja, Buer, Jan, Weiss, Siegfried
Early interactions between pathogens and host cells are often decisive for the subsequent course of infection. Here we investigated early events during infection by Listeria monocytogenes, a...
Gereke, Marcus, Gröbe, Lothar, Prettin, Silvia, Kasper, Michael, Deppenmeier, Stefanie, Gruber, Achim D, ...
Stecher, Bärbel, Robbiani, Riccardo, Walker, Alan W, Westendorf, Astrid M, Barthel, Manja, Kremer, Marcus, ...
Most mucosal surfaces of the mammalian body are colonized by microbial communities (“microbiota”). A high density of commensal microbiota inhabits the intestine and shields from infection...
Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal Integrity
Ukena, Sya N., Singh, Anurag, Dringenberg, Ulrike, Engelhardt, Regina, Seidler, Ursula, Hansen, Wiebke, ...
Huehn, Jochen, Siegmund, Kerstin, Lehmann, Joachim C.U., Siewert, Christiane, Haubold, Uta, Feuerer, Markus, ...
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this...
Role of Different T Cell Receptors in the Development of Pre–T Cells
Buer, Jan, Aifantis, Iannis, DiSanto, James P., Fehling, Hans Joerg, Boehmer, Harald Von
The development of pre–T cells with productive TCR-β rearrangements can be mediated by each the pre–T cell receptor (pre-TCR), the TCR-αβ as well as the TCR-γδ, albeit by distinct...
Buer, Jan, Lanoue, Astrid, Franzke, Anke, Garcia, Corinne, Boehmer, Harald Von, Sarukhan, Adelaida
Continuous antigenic stimulation in vivo can result in the generation of so-called “anergic” CD4+ or CD8+ T cells that fail to proliferate upon antigenic stimulation and fail to develop cytolytic...
Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype
Gustafsson, Charlotte, Mjösberg, Jenny, Matussek, Andreas, Geffers, Robert, Matthiesen, Leif, Berg, Göran, ...
Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation
He, Feng, Buer, Jan, Zeng, An-Ping, Balling, Rudi
By combining information on the yeast transcription network and high-resolution time-series data with a series of factors, support is provided for the concept that dynamic cumulative regulation is a...