Two-Parameter Characterization of Chromosome-Scale Recombination Rate (2009)
The genome-wide recombination rate ($RR$) of a species is often described by one parameter, the ratio between total genetic map length ($G$) and physical map length ($P$), measured in centiMorgans...
Freudenberg, Jan, Wang, Mingyi, Yang, Yaning, Li, Wentian
Abstract Background Several features are known to correlate with the GC-content in the human genome, including recombination rate, gene density and distance to telomere. However, by testing for...
Cichon, Sven, Winge, Ingeborg, Mattheisen, Manuel, Georgi, Alexander, Karpushova, Anna, Freudenberg, Jan, ...
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is controlled by...
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease (2008)
Metzger, Silke, Rong, Juan, Nguyen, Huu-Phuc, Cape, Austin, Tomiuk, Juergen, Soehn, Anne S., ...
A polyglutamine repeat expansion of more than 36 units in a protein called huntingtin (htt) is the only known cause of Huntington's disease (HD). The expanded repeat length is inversely correlated...
Freudenberg, Jan, Fu, Ying-Hui, Ptácek, Louis J.
Motivation: We hypothesized that recombination rates might be increased at genetic loci that are subject to more intense selection. Here, we test this hypothesis by using a recently published set of...
Cannabinoid receptor type 2 gene is associated with human osteoporosis (2005)
Karsak, Meliha, Cohen-Solal, Martine, Freudenberg, Jan, Ostertag, Agnes, Morieux, Caroline, Kornak, Uwe, ...
Osteoporosis is one of the most common degenerative diseases. It is characterized by reduced bone mineral density (BMD) with an increased risk for bone fractures. There is a substantial genetic...
Freudenberg-Hua, Yun, Freudenberg, Jan, Kluck, Nadine, Cichon, Sven, Propping, Peter, Nöthen, Markus M.
The detailed investigation of variation in functionally important regions of the human genome is expected to promote understanding of genetically complex diseases. We resequenced 65 candidate genes...
Thesis (doctoral)--Universität Hamburg, 1997.
Freudenberg-Hua, Yun, Freudenberg, Jan, Kluck, Nadine, Cichon, Sven, Propping, Peter, Nöthen, Markus M.
The detailed investigation of variation in functionally important regions of the human genome is expected to promote understanding of genetically complex diseases. We resequenced 65 candidate genes...
Freudenberg-Hua, Yun, Freudenberg, Jan, Kluck, Nadine, Cichon, Sven, Propping, Peter, Nöthen, Markus M.
The detailed investigation of variation in functionally important regions of the human genome is expected to promote understanding of genetically complex diseases. We resequenced 65 candidate genes...
The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease
Van Den Bogaert, Ann, Schumacher, Johannes, Schulze, Thomas G., Otte, Andreas C., Ohlraun, Stephanie, Kovalenko, Svetlana, ...
We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of...
Hillmer, Axel M., Hanneken, Sandra, Ritzmann, Sibylle, Becker, Tim, Freudenberg, Jan, Brockschmidt, Felix F., ...
Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the...