Valnickova, Zuzana, Thaysen-Andersen, Morten, Højrup, Peter, Christensen, Trine, Sanggaard, Kristian W, Kristensen, Torsten, ...
Abstract Background TAFI is a plasma protein assumed to be an important link between coagulation and fibrinolysis. The three-dimensional crystal structures of authentic mature bovine TAFI (TAFIa) in...
BMC Biochemistry BioMed Central (2009)
Zuzana Valnickova, Morten Thaysen-andersen, Peter Højrup, Trine Christensen, Kristian W Sanggaard, Torsten Kristensen, ...
Research article Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI)
Mallorquí-Fernández, Noemí, Manandhar, Surya P., Mallorquí-Fernández, Goretti, Usón, Isabel, Wawrzonek, Katarzyna, Kantyka, Tomasz, ...
20 pages, 5 figures, 2 tables.-- PMID: 17993455 [PubMed].-- PMCID: PMC2772895.-- NIHMSID: NIHMS65935.-- Available online Nov 7, 2007.
Petersen, Steen V, Valnickova, Zuzana, Oury, Tim D, Crapo, James D, Chr Nielsen, Niels, Enghild, Jan J
Abstract Background Human extracellular superoxide dismutase (EC-SOD) is a tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space. We have previously...
Lizotte, Pierre-Paul, Hanford, Lana E, Enghild, Jan J, Nozik-Grayck, Eva, Giles, Brenda-Louise, Oury, Tim D
Abstract Background The receptor for advanced glycation end products (mRAGE) is associated with pathology in most tissues, while its soluble form (sRAGE) acts as a decoy receptor. The adult lung is...
Biochemical importance of glycosylation of plasminogen activator inhibitor-1 (2003)
Pedersen, Katrine E, Skottrup, Peter, Christensen, Anni, Naessens, Dominik, Deinum, Johanna, ...
The serpin plasminogen activator inhibitor-1 (PAI-1) is a potential target for anti-thrombotic and anti-cancer therapy. PAI-1 has 3 potential sites for N-linked glycosylation. We demonstrate here...
Calbindin D28k exhibits properties characteristic of a Ca2+ sensor. (2002)
Berggard, Tord, Miron, Simona, Onnerfjord, Patrik, Thulin, Eva, Akerfeldt, Karin S., Enghild, Jan J., ...
Calbindin D28k is a member of the calmodulin super-family of Ca2+ -binding proteins and contains six EF-hands. The protein is generally believed to function as a Ca2+ buffer, but the studies...
Angiostatin binds ATP synthase on the surface of human endothelial cells
Moser, Tammy L., Stack, M. Sharon, Asplin, Iain, Enghild, Jan J., Højrup, Peter, Everitt, Lorraine, ...
Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell migration and proliferation. To determine whether the mechanism by...
The dual nature of human extracellular superoxide dismutase: One sequence and two structures
Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...
Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...
Cunningham, Anna C, Hasty, Karen A, Enghild, Jan J, Mast, Alan E
Vascular injury results in the activation of coagulation and the release of proteolytic enzymes from neutrophils and connective- tissue cells. High concentrations of these inflammatory proteinases...
Petersen, Steen V, Valnickova, Zuzana, Enghild, Jan J
Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that...
Angiostatin binds ATP synthase on the surface of human endothelial cells
Moser, Tammy L., Stack, M. Sharon, Asplin, Iain, Enghild, Jan J., Højrup, Peter, Everitt, Lorraine, ...
Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis and an inhibitor of endothelial cell migration and proliferation. To determine whether the mechanism by...
The dual nature of human extracellular superoxide dismutase: One sequence and two structures
Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...
Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...
Cunningham, Anna C, Hasty, Karen A, Enghild, Jan J, Mast, Alan E
Vascular injury results in the activation of coagulation and the release of proteolytic enzymes from neutrophils and connective- tissue cells. High concentrations of these inflammatory proteinases...
Petersen, Steen V, Valnickova, Zuzana, Enghild, Jan J
Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or supersedes that...
Lizotte, Pierre-Paul, Hanford, Lana E, Enghild, Jan J, Nozik-Grayck, Eva, Giles, Brenda-Louise, Oury, Tim D
Petersen, Steen V, Valnickova, Zuzana, Oury, Tim D, Crapo, James D, Chr Nielsen, Niels, Enghild, Jan J
Afshari, Natalie A., Bahadur, Rosanna P., Eifrig, David E., Thogersen, Ida B., Enghild, Jan J., Klintworth, Gordon K.
Halaban, Ruth, Krauthammer, Michael, Pelizzola, Mattia, Cheng, Elaine, Kovacs, Daniela, Sznol, Mario, ...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It...
Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI)
Valnickova, Zuzana, Thaysen-Andersen, Morten, Højrup, Peter, Christensen, Trine, Sanggaard, Kristian W, Kristensen, Torsten, ...
Potential Clinical Importance of the Activation Peptide of Prostate-specific Antigen
Voeghtly, Laura M., Thøgersen, Ida B., Valnickova, Zuzana, Sanggaard, Kristian W., Chu, Charleen T., Oury, Tim D., ...
Prostate cancer is the second leading cause of cancer death in men. Prostate specific antigen (PSA) is currently the best marker available for screening and monitoring disease recurrence, but its use...
Anand, Kanchan, Pallares, Irantzu, Valnickova, Zuzana, Christensen, Trine, Vendrell, Josep, Wendt, K. Ulrich, ...
Mature thrombin-activable fibrinolysis inhibitor (TAFIa) is a highly unstable metallocarboxypeptidase that stabilizes blood clots by clipping C-terminal lysine residues from partially degraded...
Karring, Henrik, Valnickova, Zuzana, Thøgersen, Ida B., Hedegaard, Chris J., Møller-Pedersen, Torben, Kristensen, Torsten, ...
Sanggaard, Kristian W., Sonne-Schmidt, Carsten S., Krogager, Toke P., Kristensen, Torsten, Wisniewski, Hans-Georg, Thøgersen, Ida B., ...
Studies of the interaction between Bikunin proteins, tumor necrosis factor-stimulated gene-6 protein (TSG-6), and glycosaminoglycans have revealed a unique catalytic activity where TSG-6/heavy chain...
The Proteome of Seed Development in the Model Legume Lotus japonicus1[C][W]
Dam, Svend, Laursen, Brian S., Ørnfelt, Jane H., Jochimsen, Bjarne, Stærfeldt, Hans Henrik, Friis, Carsten, ...
We have characterized the development of seeds in the model legume Lotus japonicus. Like soybean (Glycine max) and pea (Pisum sativum), Lotus develops straight seed pods and each pod contains...