Jan Oscarsson

Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells (2008)

Oscarsson, Jan, Karched, Maribasappa, Thay, Bernard, Chen, Casey, Asikainen, Sirkka

Abstract Background Aggregatibacter actinomycetemcomitans is an oral bacterium associated with aggressive forms of periodontitis. Increasing evidence points to a link between periodontitis and...

136 Flexible Automation and Intelligent Manufacturing, FAIM2005, Bilbao, Spain Information Fusion for Simulation Based Decision Support in Manufacturing (2008)

Jan Oscarsson, Sten F Andler

Robust and informed decisions are important for the efficient and effective operation of installed production facilities. The paper discusses information fusion and situations for decision making, as...

MANUFACTURING SIMULATION: GOOD PRACTICE, PITFALLS, AND ADVANCED APPLICATIONS (2008)

Jan Oscarsson, Amos Ng, Mats Jägstam, Thomas Karlsson

The paper describes manufacturing simulation with a focus on discrete event simulation and computer aided robotics. Some generic good practices, problems, and pitfalls in the use of simulation are...

Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form (2008)

Karched, Maribasappa, Ihalin, Riikka, Eneslätt, Kjell, Zhong, Deyu, Oscarsson, Jan, Wai, Sun N, ...

Abstract Background Aggregatibacter actinomycetemcomitans is an oral bacterium associated with aggressively progressing periodontitis. Extracellular release of bacterial outer membrane proteins has...

Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice (2006)

Andersson, Niklas, Lindberg, Marie K, Svensson, Johan, Swanson, Charlotte, ...

OBJECTIVE: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate...

Simulation Based Decision Support for Manufacturing System Life Cycle Flexible Automation and (2004)

Jan Oscarsson

Previous research has highlighted the role of virtual engineering tools in the development of manufacturing machinery systems. Simulation models created for this purpose can potentially be used to...

Silencing and Activation of ClyA Cytotoxin Expression in Escherichia coli

Westermark, Marie, Oscarsson, Jan, Mizunoe, Yoshimitsu, Urbonaviciene, Jurate, Uhlin, Bernt Eric

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene of Escherichia coli K-12. Genetic analysis suggested that clyA is silenced by the nucleoid protein H-NS. Purified H-NS...

Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages

Lai, Xin-He, Arencibia, Ignacio, Johansson, Anders, Wai, Sun Nyunt, Oscarsson, Jan, Kalfas, Sotos, ...

Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were...

Characterization of a Pore-Forming Cytotoxin Expressed by Salmonella enterica Serovars Typhi and Paratyphi A

Oscarsson, Jan, Westermark, Marie, Löfdahl, Sven, Olsen, Björn, Palmgren, Helena, Mizunoe, Yoshimitsu, ...

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that...

Characterization of Dominantly Negative Mutant ClyA Cytotoxin Proteins in Escherichia coli

Wai, Sun Nyunt, Westermark, Marie, Oscarsson , Jan, Jass , Jana, Maier, Elke, Benz, Roland, ...

We report studies of the subcellular localization of the ClyA cytotoxic protein and of mutations causing defective translocation to the periplasm in Escherichia coli. The ability of ClyA to...

Silencing and Activation of ClyA Cytotoxin Expression in Escherichia coli

Westermark, Marie, Oscarsson, Jan, Mizunoe, Yoshimitsu, Urbonaviciene, Jurate, Uhlin, Bernt Eric

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene of Escherichia coli K-12. Genetic analysis suggested that clyA is silenced by the nucleoid protein H-NS. Purified H-NS...

Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages

Lai, Xin-He, Arencibia, Ignacio, Johansson, Anders, Wai, Sun Nyunt, Oscarsson, Jan, Kalfas, Sotos, ...

Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were...

Characterization of a Pore-Forming Cytotoxin Expressed by Salmonella enterica Serovars Typhi and Paratyphi A

Oscarsson, Jan, Westermark, Marie, Löfdahl, Sven, Olsen, Björn, Palmgren, Helena, Mizunoe, Yoshimitsu, ...

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that...

Characterization of Dominantly Negative Mutant ClyA Cytotoxin Proteins in Escherichia coli

Wai, Sun Nyunt, Westermark, Marie, Oscarsson , Jan, Jass , Jana, Maier, Elke, Benz, Roland, ...

We report studies of the subcellular localization of the ClyA cytotoxic protein and of mutations causing defective translocation to the periplasm in Escherichia coli. The ability of ClyA to...

SarA Is a Repressor of hla (α-Hemolysin) Transcription in Staphylococcus aureus: Its Apparent Role as an Activator of hla in the Prototype Strain NCTC 8325 Depends on Reduced Expression of sarS▿

Oscarsson, Jan, Kanth, Anna, Tegmark-Wisell, Karin, Arvidson, Staffan

In most Staphylococcus aureus strains, inactivation of sarA increases hla transcription, indicating that sarA is a repressor. However, in S. aureus NCTC 8325 and its derivatives, used for most...