Jan Retèl

Biological consequences of DNA damage introduced in bacteriophage PM2 DNA by hydrogen peroxide-mediated free radial reactions (1996)

Gille, Johan J.P., Wientjes, Natasja M., Lafleur, M.Vincent M., Joenje, Hans, Retèl, Jan

In order to study the biological consequences of DNA damage induced by H2O2-mediated free radical reactions, DNA from bacteriophage PM2 was exposed to H2O2, Fe3+-citrate and ascorbate either alone or...

Influence of the antioxidant N-acetylcysteine and its metabolites on damage induced by bleomycin in PM2 bacteriophage DNA (1996)

Cloos, Jacqueline, Gille, Johan J.P., Steen, Ivar, Lafleur, M.Vincent, Retèl, Jan, Snow, Gordon B., ...

Bleomycin is considered to be a useful model compound for studying environmental carcinogenesis, due to its broad spectrum of DNA damaging properties. In addition, bleomycin is a useful antitumor...

Mutational specificity of {gamma}-rays differs for the same target in plasmid DNA and double-stranded (RF) M13 bacteriophage DNA (1991)

Hoebee, Barbara, Loman, Henk, Brouwer, Jaap, Retèl, Jan

In the lacZα gene of a pUC plasmid a 144 bp insert was cloned as target for mutagenesis. Irradiation of the plasmid in a diluted aqueous solution by 60Co γ-rays under oxic conditions leads to a...

By-pass of the major aminofluorene-DNA adduct during in vivo replication of single- and double-stranded oX174 DNA treated with N-hydroxy-2-aminofluorene (1985)

Lutgerink, Jan T., Retèl, Jan, Westra, J.Gerard, Welling, Maarten C., Loman, Henk, Kriek, Erik

To examine the effects of aminofluorene-DNA adduct formation on the biological activity of DNA, single-stranded (ss) øX174 DNA and øX174 replicative form (RF) DNA were modified to different extents...

Genetic organization of the ribosomal transcription units of the yeast Saccharomyces carisbergensis (1978)

Meyerink, Jan H., Retèl, Jan, Raué, Hendrik A., Planta, Rudi J., Van Der Ende, Arie

The genetic organization of the multiple ribosomal transcription units (RTUs) on the genome of the yeast Saccharomyces carlsbergensis was studied by electron microscopy of purified ribosomal DNA...