Jan Tavernier

Protein Engineering vol.12 no.1 pp.71–78, 1999 Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT) (2009)

Frank Peelman, Berlinda Vanloo, Oscar Perez-mendez, Anne Decout, Jean-luc Verschelde, Christine Labeur, ...

5To whom correspondence should be addressed. E-mail:

An empirical framework for binary interactome mapping (2009)

Venkatesan, Kavitha, Rual, Jean-Francois, Vazquez, Alexei, Stelzl, Ulrich, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, ...

Several attempts have been made to systematically map protein-protein interaction, or 'interactome', networks. However, it remains difficult to assess the quality and coverage of existing data sets....

Array MAPPIT: High-Throughput Interactome Analysis in Mammalian Cells (2009)

Lievens, Sam, Vanderroost, Nele, Van Der Heyden, José, Gesellchen, Viola, Vidal, Marc, Tavernier, Jan

Physical interactions between proteins play a key role in probably every cellular process. Efforts to chart the protein interaction networks are ongoing in a number of model organisms using a...

An experimentally derived confidence score for binary protein-protein interactions (2009)

Braun, Pascal, Tasan, Murat, Dreze, Matija, Barrios-Rodiles, Miriam, Lemmens, Irma, Yu, Haiyuan, ...

Information on protein-protein interactions is of central importance for many areas of biomedical research. At present no method exists to systematically and experimentally assess the quality of...

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network (2009)

Simonis, Nicolas, Rual, Jean-Francois, Carvunis, Anne-Ruxandra, Tasan, Murat, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, ...

Abstract: To provide accurate biological hypotheses and elucidate global properties of cellular networks, systematic identification of protein-protein interactions must meet high quality standards....

MAPPIT (Mammalian Protein-Protein Interaction Trap) analysis of early steps in Toll-Like receptor signalling (2009)

Ulrichts, Peter, Lemmens, Irma, Lavens, Delphine, Beyaert, Rudi, Tavernier, Jan

The mammalian protein-protein interaction trap (MAPPIT) is a two-hybrid technique founded on type I cytokine signal transduction. Thereby, bait and prey proteins are linked to signalling deficient...

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients (2009)

Gevaert, Philippe, Hellman, C., Lundblad, L., Lundahl, J., Holtappels, Gabriële, Van Cauwenberge, Paul, ...

Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5R alpha) isoform, or a secreted (SOL IL-5R alpha) isoform,...

TLR-4, IL-1R and TNF-R signaling to NF-kappa B: variations on a common theme (2008)

Verstrepen, Lynn, Bekaert, Tine, CHAU, TL, Tavernier, Jan, CHARIOT, A, Beyaert, Rudi

A protein domain-based interactome network for C-elegans early embryogenesis (2008)

BOXEM, M, MALIGA, Z, KLITGORD, N, LI, N, Lemmens, Irma, MANA, M, ...

MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells (2008)

Pattyn, Els, Lavens, Delphine, Van Der Heyden, José, Verhee, Annick, Lievens, Sam, Lemmens, Irma, ...

MAPPIT analysis of early Toll-like receptor signalling events (2008)

Ulrichts, Peter, Tavernier, Jan

Elongin B/C recruitment regulates substrate binding by CIS (2008)

Piessevaux, Julie, De Ceuninck, Leentje, Catteeuw, Dominiek, Peelman, Frank, Tavernier, Jan

Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways (2008)

Wauman, Joris, De Smet, Anne-Sophie, Catteeuw, Dominiek, BELSHAM, D, Tavernier, Jan

High-quality binary protein interaction map of the yeast interactome network (2008)

YU, HY, BRAUN, P, YILDIRIM, MA, Lemmens, Irma, VENKATESAN, K, SAHALIE, J, ...

Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers (2008)

Fayazpour, Farzaneh, Lucas, Bart, Vandenbroucke, Roosmarijn, Derveaux, Stefaan, Tavernier, Jan, Lievens, Sam, ...

A protein domain-based interactome network for C. elegans early embryogenesis (2008)

Boxem, Mike, Maliga, Zoltan, Klitgord, Niels, Li, Na, Lemmens, Irma, Mana, Miyeko, ...

Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored...

The many faces of the SOCS box (2008)

Piessevaux, Julie, Lavens, Delphine, Peelman, Frank, Tavernier, Jan

The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-terminus of over 70 human proteins. It is usually coupled to a protein interaction module such as an SH2 domain...

MAPPIT: a versatile tool to study cytokine receptor signalling (2008)

Lemmens, Irma, Lievens, Sam, Tavernier, Jan

MAPPIT (mammalian protein-protein interaction trap) is a cytokine receptor-based two-hybrid method that operates in intact mammalian cells. A bait is fused C-terminally to a STAT (signal transducer...

Functional Characterization of Naturally Occurring Pathogenic Mutations in the Human Leptin Receptor (2008)

Kimber, Wendy, Peelman, Frank, Prieur, Xavier, Wangensteen, Theresia, O'Rahilly, Stephen, Tavernier, Jan, ...

We have recently reported the first naturally occurring missense mutations in the leptin receptor (LR) in patients with severe obesity. We have examined the molecular mechanisms by which these...

Multiple roles for the SOCS box (2008)

Piessevaux, Julie, Lavens, Delphine, Peelman, Frank, Tavernier, Jan

Leptin induces inflammation-related genes in RINm5F insulinoma cells (2007)

Hekerman, Paul, Zeidler, Julia, Korfmacher, Stefanie, Bamberg-Lemper, Simone, Knobelspies, Holger, Zabeau, Lennart, ...

Abstract Background Leptin acts not only on hypothalamic centers to control food intake but has additional functions in peripheral tissues, e.g . inhibition of insulin secretion from pancreatic...

MAPPIT analysis of TLR adaptor complexes (2007)

Ulrichts, Peter, Peelman, Frank, Beyaert, Rudi, Tavernier, Jan

The C-terminus of CIS defines its interaction pattern (2007)

Lavens, Delphine, Ulrichts, Peter, Catteeuw, Dominiek, Gevaert, Kris, Vandekerckhove, Joël, Peelman, Frank, ...

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling (2007)

ERKELAND, SJ, AARTS, LH, IRANDOUST, M, ROOVERS, O, KLOMP, A, VALKHOF, M, ...

Leptin induces inflammation-related genes in RINm5F insulinoma cells (2007)

HEKERMAN, P, ZEIDLER, J, KORFMACHER, S, BAMBERG-LEMPER, S, KNOBELSPIES, H, Zabeau, Lennart, ...

Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor (2007)

Uyttendaele, Isabel, Lemmens, Irma, Verhee, Annick, De Smet, Anne-Sophie, Vandekerckhove, Joël, Lavens, Delphine, ...

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology (2007)

Vereecke, Lars, Lievens, Sam, Tavernier, Jan, Van Loo, Geert, Sze, Mozes, Beyaert, Rudi

The MAPPIT toolbox: novel strategies to analyze molecular interactions in intact cells (2007)

Tavernier, Jan, Lemmens, Irma, Lievens, Sam

BMC Molecular Biology BioMed Central (2007)

Paul Hekerman, Julia Zeidler, Stefanie Korfmacher, Simone Bamberg, Holger Knobelspies, Lennart Zabeau, ...

Research article Leptin induces inflammation-related genes in RINm5F insulinoma cells

A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update (2006)

Waelput, Wim, Brouckaert, Peter, Broekaert, Daniël, Tavernier, Jan

Techniques: New pharmacological perspectives for the leptin receptor (2006)

Peelman, Frank, COUTURIER, C, DAM, J, Zabeau, Lennart, Tavernier, Jan, JOCKERS, R

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin center dot leptin receptor complex (2006)

Peelman, Frank, Iserentant, Hannes, De Smet, Anne-Sophie, Vandekerckhove, Joël, Zabeau, Lennart, Tavernier, Jan

A complex interaction pattern of CIS and SOCS2 with the leptin receptor (2006)

Lavens, Delphine, Montoye, Tony, Piessevaux, Julie, Zabeau, Lennart, Vandekerckhove, Joël, Gevaert, Kris, ...

Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy (2006)

Montoye, Tony, Piessevaux, Julie, Lavens, Delphine, Wauman, Joris, Catteeuw, Dominiek, Vandekerckhove, Joël, ...

MASPIT: Three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells (2006)

CALIGIURI, M, MOLZ, L, LIU, Q, KAPLAN, F, XU, JP, MAJETI, JZ, ...

Review: negative regtilation of leptin receptor signalling (2006)

Lavens, Delphine, Piessevaux, Julie, Tavernier, Jan

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps (2006)

Gevaert, Philippe, LANG-LOIDOLT, D, LACKNER, A, STAMMBERGER, H, STAUDINGER, H, VAN ZELE, T, ...

Single protein complex visualization: Seeing is believing (2006)

Lievens, Sam, Tavernier, Jan

Functional cross-modulation between SOCS proteins can stimulate cytokine signaling (2006)

Piessevaux, Julie, Lavens, Delphine, MONTOYE, T, Wauman, Joris, Catteeuw, Dominiek, Vandekerckhove, Joël, ...

Reverse MAPPIT detects disruptors of protein-protein interactions in human cells (2006)

Lemmens, Irma, Lievens, Sam, EYCKERMAN, S, Tavernier, Jan

Two hybrid and its recent adaptations (2006)

Lievens, Sam, Lemmens, Irma, MONTOYE, T, EYCKERMAN, S, Tavernier, Jan

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines (2005)

HEKERMAN, P, ZEIDLER, J, BAMBERG-LEMPER, S, KNOBELSPIES, H, Lavens, Delphine, Tavernier, Jan, ...

Immunostimulatory potential of hepatitis B nucleocapsid preparations: lipopolysaccharide contamination should not be overlooked (2005)

Vanlandschoot, Peter, Van Houtte, Freya, Ulrichts, Peter, Tavernier, Jan, Leroux-Roels, Geert

Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists (2005)

Peelman, Frank, Iserentant, Hannes, Eyckerman, Sven, Zabeau, Lennart, Tavernier, Jan

A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach (2005)

Montoye, Tony, Lemmens, Irma, Catteeuw, Dominiek, Eyckerman, Sven, Tavernier, Jan

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells (2005)

Eyckerman, Sven, Lemmens, Irma, Catteeuw, Dominiek, Verhee, Annick, Vandekerckhove, Joël, Lievens, Sam, ...

Mapping of the interface between leptin and the leptin receptor CRH2 domain (2005)

ISERENTANT, H, Peelman, Frank, DEFEAU, D, Vandekerckhove, Joël, Zabeau, Lennart, Tavernier, Jan

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains (2005)

Zabeau, Lennart, DEFEAU, D, ISERENTANT, H, Vandekerckhove, Joël, Peelman, Frank, Tavernier, Jan

Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay (2004)

Zabeau, Lennart, Defeau, Delphine, Van Der Heyden, José, Iserentant, Hannes, Vandekerckhove, Joël, Tavernier, Jan

Design of a fluorescence-activated cell sorting-based Mammalian protein-protein interaction trap (2004)

Lievens, Sam, HEYDEN, J, Vertenten, Els, Plum, Jean, Vandekerckhove, Joël, Tavernier, Jan

Differential activation of signalling pathways by the intracellular tyrosines of the leptin receptor (2004)

BECKER, W, HEKERMAN, P, ZEIDLER, J, BAMBERG-LEMPER, S, Tavernier, Jan, JOOST, HG

Role of intracellular tyrosine residues in the desensitisation of leptin receptor signal transduction (2004)

ZEIDLER, J, HEKERMAN, P, Tavernier, Jan, BECKER, W

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases (2004)

Peelman, Frank, Waelput, Wim, Iserentant, Hannes, Lavens, Delphine, Eyckerman, Sven, Zabeau, Lennart, ...

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter (2004)

Roosbeek, Stein, Peelman, Frank, Verhee, Annick, Labeur, Christine, CASTER, H, Lensink, Marc, ...

Mapping of the leptin binding sites and design of a leptin antagonist (2004)

Peelman, Frank, Van Beneden, Katrien, Zabeau, Lennart, Iserentant, Hannes, Ulrichts, Peter, Defeau, Delphine, ...

Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease (2004)

ROHDE, G, Gevaert, Philippe, Holtappels, Gabriële, FRANSEN, L, BORG, I, WIETHEGE, A, ...

Regulation of the ABCA1 transporter activity by protein kinase CK2 (2004)

STEIN, R, Peelman, Frank, Tavernier, Jan, Rosseneu, Maryvonne

The ins and outs of leptin receptor activation (2003)

Zabeau, Lennart, Lavens, Delphine, Peelman, Frank, Eyckerman, Sven, Vandekerckhove, Joël, Tavernier, Jan

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells (2003)

Lemmens, Irma, Eyckerman, Sven, Zabeau, Lennart, Catteeuw, Dominiek, Vertenten, Els, VERSCHUEREN, K, ...

Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis (2003)

GEVAERT, P, Bachert, Claus, Holtappels, Gabriële, NOVO, CP, Van Der Heyden, José, FRANSEN, L, ...

Interleukin 5, eosinophilic diseases and therapeutic intervention (2003)

Zabeau, Lennart, Gevaert, Philippe, Bachert, Claus, Tavernier, Jan

Structure and regulation of the ABCA transporters (2003)

Rosseneu, Maryvonne, Roosbeek, Stein, Peelman, Frank, Lensink, Marc, Tavernier, Jan

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells (2003)

Lemmens, Irma, Eyckerman, Sven, Zabeau, Lennart, Catteeuw, Dominiek, Vertenten, Els, Verschueren, Kristin, ...

We recently reported a two‐hybrid trap for detecting protein–protein interactions in intact mammalian cells (MAPPIT). The bait protein was fused to a STAT recruitment‐deficient,...

A role for leptin in the systemic inflammatory response syndrome and immune response. (2002)

Waelput, Wim, Brouckaert, Peter, Broekaert, Daniël, Tavernier, Jan

Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals. (2002)

Broekaert, Daniël, Eyckerman, Sven, Lavens, Delphine, VERHEE, A, Waelput, Wim, Vandekerckhove, Joël, ...

Design and use of a mammalian protein-protein interaction trap (MAPPIT) (2002)

Eyckerman, Sven, Lemmens, Irma, Lievens, Sam, VERHEE, A, Vandekerckhove, Joël, ...

Methods to map protein interactions in mammalian cells: different tools to address different questions. (2002)

Eyckerman, Sven, Tavernier, Jan

MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells. (2002)

Tavernier, Jan, Eyckerman, Sven, Lemmens, Irma, Vandekerckhove, Joël, Van Ostade, Xaveer

A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins. (2001)

DESRUMAUX, C, Labeur, Christine, VERHEE, A, Tavernier, Jan, Vandekerckhove, Joël, Rosseneu, Maryvonne, ...

Down-modulation of type-1 interferon responses by receptor cross-competition for a shared Jak kinase. (2001)

DONDI, E, Pattyn, Els, LUTFALLA, G, Van Ostade, Xaveer, UZE, G, PELLEGRINI, S, ...

Design and application of a cytokine-receptor-based interaction trap. (2001)

Eyckerman, Sven, VERHEE, A, Lemmens, Irma, Van Ostade, Xaveer, Vandekerckhove, Joël, ...

Effect of mutations of N- and C-terminal charged residues on the activity of LCAT. (2001)

Peelman, Frank, Vanloo, Berlinda, Verschelde, Jean-Luc, Labeur, Christine, CASTER, H, TAVEIRNE, J, ...

A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. (2001)

WAELPUT, W, Broekaert, Daniël, Vandekerckhove, Joël, Brouckaert, Peter, Tavernier, Jan, Libert, Claude

Neutralizing monoclonal antibodies can potentiate IL-5 signaling. (2001)

Zabeau, Lennart, Broekaert, Daniël, VERHEE, A, Vandekerckhove, Joël, WU, SJ, ...

IL-5 Receptor (2000)

Bagley, Christopher James, Tavernier, Jan, Woodcock, Joanna M, Lopez, Angel Francisco

IL-5 Receptor (2000)

Bagley, Christopher James, Tavernier, Jan, Woodcock, Joanna M, Lopez, Angel Francisco

Evidence for local eosinophil differentiation within allergic nasal mucosa: Inhibition with soluble IL-5 receptor. (2000)

CAMERON, L, CHRISTODOULOPOULOS, P, LAVIGNE, F, NAKAMURA, Y, EIDELMAN, D, MCEUEN, A, ...

Headgroup specificity of lecithin cholesterol acyltransferase for monomeric and vesicular phospholipids. (2000)

Christiaens, Bart, Vanloo, Berlinda, GOUYETTE, C, Van Vynckt, Inge, CASTER, H, TAVEIRNE, J, ...

Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit. (2000)

Tavernier, Jan, VERHEE, A, BRUSSELLE, G, Van Ostade, Xaveer, Vandekerckhove, Joël, ...

Relationship between structure and biochemical phenotype of lecithin : cholesterol acyltransferase (LCAT) mutants causing fish-eye disease. (2000)

Vanloo, Berlinda, Peelman, Frank, Deschuymere, Kristof, TAVEIRNE, J, VERHEE, A, GOUYETTE, C, ...

A sensitive and versatile bioassay for ligands that signal through receptor clustering. (2000)

Van Ostade, Xaveer, Schauvliege, Liesbeth, Pattyn, Els, VERHEE, A, Vandekerckhove, Joël, Tavernier, Jan

Identification and expression analysis of leptin-regulated immediate early response and late target genes. (2000)

WAELPUT, W, VERHEE, A, Broekaert, Daniël, Eyckerman, Sven, Vandekerckhove, Joël, BEATTIE, JH, ...

Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. (2000)

GOUNNI, AS, GREGORY, B, NUTKU, E, ARIS, F, LATIFA, K, MINSHALL, E, ...

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. (2000)

Eyckerman, Sven, Broekaert, Daniël, VERHEE, A, Vandekerckhove, Joël, Tavernier, Jan

Dimerization of the interferon type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity. (1999)

PATTYN, E, VAN OSTADE, X, SCHAUVLIEGE, L, VERHEE, A, Kalai, Michaël, Vandekerckhove, Joël, ...

Dimerisation of the interferon type 1 receptor IFNaR2 subunit is sufficient for induction of interferon effector genes, but not for antiviral activity. (1999)

Pattyn, Els, Van Ostade, Xaveer, Schauvliege, Liesbeth, VERHEE, A, Vandekerckhove, Joël, Tavernier, Jan

Characterisation of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase. (1999)

Vanloo, Berlinda, Peelman, Frank, Labeur, Christine, Vandekerckhove, Joël, Tavernier, Jan, Rosseneu, Maryvonne

Analysis of the Expression Pattern of Human Interleukin-5 Receptor a Isoforms in Vitro (1999)

Tavernier, Jan, VERHEE, A, Vandekerckhove, Joël, Van Ostade, Xaveer

The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein. (1999)

Van Ostade, Xaveer, VERHEE, A, Vandekerckhove, Joël, Tavernier, Jan

Effects of natural mutations in lecithin : cholesterol acyltransferase on the enzyme structure and activity. (1999)

Peelman, Frank, Verschelde, Jean-Luc, Vanloo, Berlinda, Ampe, Christophe, Labeur, Christine, Tavernier, Jan, ...

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor. (1999)

THIEL, S, BEHRMANN, I, TIMMERMANN, A, DAHMEN, H, MULLER-NEWEN, G, SCHAPER, F, ...

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT). (1999)

Peelman, Frank, VANLOO, B, PEREZ-MENDEZ, O, DECOUT, A, VERSCHELDE, JL, Labeur, Christine, ...

Eosinophil development and bone marrow and tissue eosinophils in atopic asthma. (1999)

ROBINSON, DS, NORTH, J, ZEIBECOGLOU, K, YING, S, MENG, Q, RANKIN, S, ...

LCAT defects and low HDL levels. (1999)

Rosseneu, Maryvonne, Peelman, Frank, VERSCHELDE, JL, VANLOO, B, Labeur, Christine, Tavernier, Jan, ...

Analysis of Tyr to Phe and the fa/fa mutations in the leptin receptor in PC12 cells. (1999)

Eyckerman, Sven, WAELPUT, W, VERHEE, A, Broekaert, Daniël, Vandekerckhove, Joël, Tavernier, Jan

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. (1999)

HERMANNS, HM, RADTKE, S, HAAN, C, Tavernier, Jan, HEINRICH, PC, ...

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT) (1999)

Peelman, Frank, Vanloo, Berlinda, Perez-Mendez, Oscar, Decout, Anne, Verschelde, Jean-Luc, Labeur, Christine, ...

Lecithin cholesterol acyltransferase (LCAT) is an interfacial enzyme active on both high-density (HDL) and low-density lipoproteins (LDL). Threading alignments of LCAT with lipases suggest that...

Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. (1998)

THIEL, S, BEHRMANN, I, DITTRICH, E, MUYS, L, Tavernier, Jan, WIJDENES, J, ...

Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization. (1998)

Guisez, Yves, FACHE, I, CAMPFIELD, LA, SMITH, FJ, FARID, A, PLAETINCK, G, ...

A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling. (1998)

Peelman, Frank, VINAIMONT, N, VERHEE, A, VANLOO, B, VERSCHELDE, JL, Labeur, Christine, ...

Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism. (1998)

VERSCHELDE, JL, Ampe, Christophe, Guisez, Yves, OEFNER, C, Vandekerckhove, Joël, Tavernier, Jan

Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. (1998)

PIERCE, A, WHETTON, AD, OWEN-LYNCH, PJ, Tavernier, Jan, SPOONCER, E, DEXTER, TM, ...

Interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor receptor expression in chronic sinusitis and response to topical steroids. (1998)

WRIGHT, ED, FRENKIEL, S, AL-GHAMDI, K, GHAFFAR, O, SMALL, P, TROUTT, T, ...

Effects of natural mutations in lecithin cholesterol acyl transferase on the enzyme structure and activity (1998)

Peelman, Frank, VERSCHELDE, JL, Vanloo, Berlinda, Ampe, Christophe, Labeur, Christine, Tavernier, Jan, ...

Interleukin-5 (1998)

SANDERSON, CJ, KARLEN, S, CORNELIS, S, PLAETINCK, G, Tavernier, Jan, DEVOS, R

Analysis of the expression pattern of the human interleukin 5 a-receptor isoforms in vitro (1998)

Tavernier, Jan, VERHEE, A, VANDEKERCKHOVE, J, VAN OSTADE, X

Contribution of apo AII and LCAT oblique peptides to HDL metabolism (1998)

Vanloo, Berlinda, PEREZ-MENDEZ, O, LAMBERT, G, Tavernier, Jan, VANDEKERCKHOVE, J, BRASSEUR, R, ...

Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12. (1997)

Brusselle, Guy, Kips, Johan, Peleman, Renaat, Joos, Guy, DEVOS, RR, Tavernier, Jan, ...

A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation. (1997)

BEHRMANN, I, JANZEN, C, GERHARTZ, C, SCHMITZVANDELEUR, H, HERMANNS, H, HEESEL, B, ...

The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. (1997)

JUBINSKY, PT, KRIJANOVSKI, OI, NATHAN, DG, Tavernier, Jan, SIEFF, CA

Membrane-bound and soluble ocIL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics (1997)

YASRUEL, Z, HUMBERT, M, KOTSIMBOS, TC, PLOYSONGSANG, Y, MINSHALL, E, DURHAM, S, ...

Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. (1996)

Kips, Johan, Brusselle, Guy, Joos, Guy, Peleman, Renaat, Tavernier, Jan, DEVOS, RR, ...

ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. (1996)

LASSALLE, P, MOLET, S, JANIN, A, VANDERHEYDEN, J, Tavernier, Jan, Fiers, Walther, ...

Interleukin-5 Receptor a-subunit Gene. Regulation in Human Eosinophil Development : Identification of a Unique Cis-element that acts like an enhancer in regulating activity of the IL-5Ra promoter (1996)

SUN, Z, YERGEAU, DA, WONG, IC, TUYPENS, T, Tavernier, Jan, PAUL, CC, ...

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor a chain required for growth signal-transduction. (1995)

CORNELIS, S, FACHE, I, VANDERHEYDEN, J, Guisez, Yves, Tavernier, Jan, DEVOS, R, ...

Detailed analysis of the IL-5-IL-5Ra interaction - Characterization of crucial residues on the ligand and the receptor. (1995)

CORNELIS, S, PLAETINCK, G, DEVOS, R, VANDERHEYDEN, J, Tavernier, Jan, SANDERSON, CJ, ...

Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice. (1995)

Kips, Johan, Brusselle, Guy, Joos, Guy, Peleman, Renaat, DEVOS, RR, Tavernier, Jan, ...

Structure-activity studies of human tumour necrosis factors. (1994)

VANOSTADE, X, Tavernier, Jan, Fiers, Walther

ATTENUATION OF ALLERGIC AIRWAY INFLAMMATION IN IL-4 DEFICIENT MICE. (1994)

Brusselle, Guy, Kips, Johan, Tavernier, Jan, VANDERHEYDEN, JG, Cuvelier, Claude, Pauwels, Romain, ...

DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS. (1994)

BARBARA, JAJ, SMITH, WB, GAMBLE, JR, VANOSTADE, X, Vandenabeele, Peter, Tavernier, Jan, ...

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor. (1994)

VANOSTADE, X, Vandenabeele, Peter, Tavernier, Jan, Fiers, Walther

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR. (1993)

VANOSTADE, X, Vandenabeele, Peter, EVERAERDT, B, LOETSCHER, H, GENTZ, R, BROCKHAUS, M, ...

THE POTENTIAL ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA IN ASTHMA. (1993)

Kips, Johan, Tavernier, Jan, Joos, Guy, Peleman, Renaat, Pauwels, Romain

EFFECT OF THEOPHYLLINE ON ENDOTOXIN AND TUMOR-NECROSIS-FACTOR INDUCED AIRWAY CHANGES IN AN INVIVO ANIMAL-MODEL. (1992)

Kips, Johan, Tavernier, Jan, Peleman, Renaat, Joos, Guy, Pauwels, Romain

TUMOR-NECROSIS-FACTOR CAUSES BRONCHIAL HYPERRESPONSIVENESS IN RATS. (1992)

Kips, Johan, Tavernier, Jan, Pauwels, Romain

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin-5 receptor alpha-subunit. (1992)

Tavernier, Jan, TUYPENS, T, PLAETINCK, G, VERHEE, A, Fiers, Walther, DEVOS, R

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression (1985)

Fransen, Lucie, Muller, Rita, Marmenout, Anne, Tavernier, Jan, Heyden, José Van Der, Kawashima, Eric, ...

Tumour necrosis factor (TNF), released by induced macrophages, causes tumour necrosis in animals and kills preferentially transformed cells in vitro. mRNA induced in the established mouse monocytic...

Human fibroblast inlterferon RNA transcripts of different sizes in poly(D.poly(C) induced cells (1983)

Content, Jean, Wit, Lucas De, Tavernier, Jan, Fiers, Walter

Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-β production, contains predominantly a ±1,200 nucleotide...

Molecular cloning of human interleukin 2 cDNA and its expression in E. coli (1983)

Devos, Rene, Plaetinck, Geert, Cheroutre, Hilde, Simons, Guus, Degrave, Wim, Tavernier, Jan, ...

A recombinant plasmid containing human interleukin 2 (IL2) cDNA was identified in a cDNA library constructed from mRNA derived from PHA-TPA induced splenocytes. Using this cDNA as a hybridization...

Evidence for a unique human fibroblast interferon (IFN-{beta}1) chromosomal gene, devoid of intervening sequences (1981)

Tavernier, Jan, Derynck, Rik, Fiers, Walter

Direct restriction analysis of the human genome, using the Southern transfer technique and hybridization with a human fibroblast interferon(IFN-β) complementary DNA insert probe, revealed the...

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein–protein interactions in mammalian cells

Lemmens, Irma, Eyckerman, Sven, Zabeau, Lennart, Catteeuw, Dominiek, Vertenten, Els, Verschueren, Kristin, ...

We recently reported a two-hybrid trap for detecting protein–protein interactions in intact mammalian cells (MAPPIT). The bait protein was fused to a STAT recruitment-deficient, homodimeric...

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein–protein interactions in mammalian cells

Lemmens, Irma, Eyckerman, Sven, Zabeau, Lennart, Catteeuw, Dominiek, Vertenten, Els, Verschueren, Kristin, ...

We recently reported a two-hybrid trap for detecting protein–protein interactions in intact mammalian cells (MAPPIT). The bait protein was fused to a STAT recruitment-deficient, homodimeric...

Leptin induces inflammation-related genes in RINm5F insulinoma cells

Hekerman, Paul, Zeidler, Julia, Korfmacher, Stefanie, Bamberg-Lemper, Simone, Knobelspies, Holger, Zabeau, Lennart, ...

The C-terminus of CIS defines its interaction pattern

Lavens, Delphine, Ulrichts, Peter, Catteeuw, Dominiek, Gevaert, Kris, Vandekerckhove, Joël, Peelman, Frank, ...

Proteins of the SOCS (suppressors of cytokine signalling) family are characterized by a conserved modular structure with pre-SH2 (Src homology 2), SH2 and SOCS-box domains. Several members, including...

A Mediator Role For Metallothionein in Tumor Necrosis Factor–induced Lethal Shock

Waelput, Wim, Broekaert, Daniël, Vandekerckhove, Joël, Brouckaert, Peter, Tavernier, Jan, Libert, Claude

Tumor necrosis factor (TNF) is a proinflammatory cytokine, which is centrally involved in several inflammatory disorders. Administration of TNF leads to a potentially lethal systemic inflammatory...

HyperISGylation of Old World Monkey ISG15 in Human Cells

Pattyn, Els, Verhee, Annick, Uyttendaele, Isabel, Piessevaux, Julie, Timmerman, Evy, Gevaert, Kris, ...

The role of interleukin 5 in the production and function of eosinophils.

Tavernier, Jan, PLAETINCK, G, GUISEZ, Y, KIPS, J, PELEMAN, R, ...

A.D. Whetton, J. Gordon (ed.) Hemopoietic cell growth factors and their receptors, Blood Cell Biochemistry,New York, Plenum Publishing Corp., 1996, nr.7, pp. 321-361.

Tavernier, Jan, PLAETINCK, G, GUISEZ, Y, KIPS, J, PELEMAN, R, ...

The ß chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood 90 (5), 1867-1873(1997).

JUBINSKY, PT, KRIJANOVSKI, OI, NATHAN, DG, Tavernier, Jan, SIEFF, CA

Upregulation of alpha GM-CSF receptor in nonatopic asthma but not in atopic asthma. J. Allergy Clin. Immunol., 99, 666-672 (1997).

KOTSIMBOS, AT, HUMBERT, M, MINSHALL, E, DURHAM, S, PFISTER, R, MENZ, G, ...

IL 5 receptor regulation in allergie rhinitis and nasal polyposis. J. Allergy Clin. Immunol. 101, 250-251 (1998).

Bachert, Claus, Tavernier, Jan, RUDACK, C, VAN CAUWENBERGHE, C

The endocytosis of the IL-6 signal transducer gpl30 does not depend on activation of the Jak/STAT pathway. Evidence for a constitutive internalization of gpl30. Biochem. J., 330,47-54 (1998).

THIEL, S, BEHRMANN, I, DITTRICH, E, MUYS, L, Tavernier, Jan, WIJDENES, J, ...