Jan zur Megede

Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences (2005)

Scriba, Thomas Jens, Zur Megede, Jan, Glashoff, Richard H., Treurnicht, Florette K., Barnett, Susan W., Janse Van Rensburg, Estrelita

The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the...

Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences (2005)

Scriba, Thomas Jens, Zur Megede, Jan, Glashoff, Richard H., Treurnicht, Florette K., Barnett, Susan W., Janse Van Rensburg, Estrelita

The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the...

Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town South Africa (2002)

Zur Megede, Jan, Engelbrecht, Susan, De Oliveira, Tulio, Cassol, Sharon, Scriba, Thomas Jens, Janse Van Rensburg, Estrelita, ...

The publisher does not allow open access to the full text of this item. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal...

Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town South Africa (2002)

Zur Megede, Jan, Engelbrecht, Susan, De Oliveira, Tulio, Cassol, Sharon, Scriba, Thomas Jens, Janse Van Rensburg, Estrelita, ...

The publisher does not allow open access to the full text of this item. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal...

Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa (2001)

Engelbrecht, Susan, De Villiers, Tania, Sampson, Candice C., Zur Megede, Jan, Barnett, Susan W., Janse Van Rensburg, Estrelita

The publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the...

Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa (2001)

Engelbrecht, Susan, De Villiers, Tania, Sampson, Candice C., Zur Megede, Jan, Barnett, Susan W., Janse Van Rensburg, Estrelita

The publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the...

Vaccine effect using a live attenuated nef-deficient simian immunodeficiency virus of African green monkeys in the absence of detectable vaccine virus replication in vivo

Beer, Brigitte, Baier, Michael, Zur Megede, Jan, Norley, Stephen, Kurth, Reinhard

Immunization of adult macaques with live attenuated simian immunodeficiency viruses (SIVs) lacking the nef genes has been shown to protect against challenge with full-length pathogenic SIV. To test...

Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene

Zur Megede, Jan, Chen, Min-Chao, Doe, Barbara, Schaefer, Mary, Greer, Catherine E., Selby, Mark, ...

A major challenge for the next generation of human immunodeficiency virus (HIV) vaccines is the induction of potent, broad, and durable cellular immune responses. The structural protein Gag is highly...

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

Gardner, Jason P., Frolov, Ilya, Perri, Silvia, Ji, Yaying, MacKichan, Mary Lee, Zur Megede, Jan, ...

The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this...

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...

Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...

Variability at Human Immunodeficiency Virus Type 1 Subtype C Protease Cleavage Sites: an Indication of Viral Fitness?

De Oliveira, Tulio, Engelbrecht, Susan, Janse Van Rensburg, Estrelita, Gordon, Michelle, Bishop, Karen, Zur Megede, Jan, ...

Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1) subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To...

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

Otten, Gillis R., Schaefer, Mary, Doe, Barbara, Liu, Hong, Srivastava, Indresh, Zur Megede, Jan, ...

DNA vaccines have been used widely in experimental primate models of human immunodeficiency virus (HIV), but their effectiveness has been limited. In this study, we evaluated three technologies for...

Evaluation of Envelope Vaccines Derived from the South African Subtype C Human Immunodeficiency Virus Type 1 TV1 Strain

Lian, Ying, Srivastava, Indresh, Gómez-Román, V. Rául, Zur Megede, Jan, Sun, Yide, Kan, Elaine, ...

Human immunodeficiency virus type 1 (HIV-1) subtype C infections are on the rise in Sub-Saharan Africa and Asia. Therefore, there is a need to develop an HIV vaccine capable of eliciting broadly...

Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 Subtype B pol and gagpol DNA Vaccines

Zur Megede, Jan, Otten, Gillis R., Doe, Barbara, Liu, Hong, Leung, Louisa, Ulmer, Jeffrey B., ...

Control of the worldwide AIDS pandemic may require not only preventive but also therapeutic immunization strategies. To meet this challenge, the next generation of human immunodeficiency virus type 1...

Vaccine effect using a live attenuated nef-deficient simian immunodeficiency virus of African green monkeys in the absence of detectable vaccine virus replication in vivo

Beer, Brigitte, Baier, Michael, Zur Megede, Jan, Norley, Stephen, Kurth, Reinhard

Immunization of adult macaques with live attenuated simian immunodeficiency viruses (SIVs) lacking the nef genes has been shown to protect against challenge with full-length pathogenic SIV. To test...

Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene

Zur Megede, Jan, Chen, Min-Chao, Doe, Barbara, Schaefer, Mary, Greer, Catherine E., Selby, Mark, ...

A major challenge for the next generation of human immunodeficiency virus (HIV) vaccines is the induction of potent, broad, and durable cellular immune responses. The structural protein Gag is highly...

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

Gardner, Jason P., Frolov, Ilya, Perri, Silvia, Ji, Yaying, MacKichan, Mary Lee, Zur Megede, Jan, ...

The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this...

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...

Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...

Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 Subtype B pol and gagpol DNA Vaccines

Zur Megede, Jan, Otten, Gillis R., Doe, Barbara, Liu, Hong, Leung, Louisa, Ulmer, Jeffrey B., ...

Control of the worldwide AIDS pandemic may require not only preventive but also therapeutic immunization strategies. To meet this challenge, the next generation of human immunodeficiency virus type 1...

Variability at Human Immunodeficiency Virus Type 1 Subtype C Protease Cleavage Sites: an Indication of Viral Fitness?

De Oliveira, Tulio, Engelbrecht, Susan, Janse Van Rensburg, Estrelita, Gordon, Michelle, Bishop, Karen, Zur Megede, Jan, ...

Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1) subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To...

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

Otten, Gillis R., Schaefer, Mary, Doe, Barbara, Liu, Hong, Srivastava, Indresh, Zur Megede, Jan, ...

DNA vaccines have been used widely in experimental primate models of human immunodeficiency virus (HIV), but their effectiveness has been limited. In this study, we evaluated three technologies for...

Evaluation of Envelope Vaccines Derived from the South African Subtype C Human Immunodeficiency Virus Type 1 TV1 Strain

Lian, Ying, Srivastava, Indresh, Gómez-Román, V. Rául, Zur Megede, Jan, Sun, Yide, Kan, Elaine, ...

Human immunodeficiency virus type 1 (HIV-1) subtype C infections are on the rise in Sub-Saharan Africa and Asia. Therefore, there is a need to develop an HIV vaccine capable of eliciting broadly...