Jane A. Little

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells

Singal, Rakesh, Ferris, Richard, Little, Jane A., Wang, Shu Zhen, Ginder, Gordon D.

Methylation of cytosines in the dinucleotide CpG has been shown to suppress transcription of a number of tissue-specific genes, yet the precise mechanism is not fully understood. The vertebrate...

Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells

Singal, Rakesh, Ferris, Richard, Little, Jane A., Wang, Shu Zhen, Ginder, Gordon D.

Methylation of cytosines in the dinucleotide CpG has been shown to suppress transcription of a number of tissue-specific genes, yet the precise mechanism is not fully understood. The vertebrate...

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Kato, Gregory J., McGowan, Vicki, Machado, Roberto F., Little, Jane A., Taylor, James, Morris, Claudia R., ...

Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly associated with early mortality and markers of hemolysis, in particular, serum lactate dehydrogenase...