Scientific Commons: Janet Kristie Coller

Role of active metabolites in the use of opioids (2008)

Coller, Janet Kristie, Christrup, L. L., Somogyi, Andrew Alexander

Janet K. Coller, Lona L. Christrup, Andrew A. Somogyi

Role of active metabolites in the use of opioids (2008)

Coller, Janet Kristie, Christrup, L. L., Somogyi, Andrew Alexander

Janet K. Coller, Lona L. Christrup, Andrew A. Somogyi

Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline (2008)

Davies, Benjamin James Lloyd, Herbert, Megan K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

The definitive version may be found at www.wiley.com

Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline (2008)

Davies, Benjamin James Lloyd, Herbert, Megan K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

The definitive version may be found at www.wiley.com

Response to "No influence of ABCB1 haplotypes on methadone dosage requirement" (2008)

Coller, Janet Kristie, Barratt, Daniel, Somogyi, Andrew Alexander

Response to "No influence of ABCB1 haplotypes on methadone dosage requirement" (2008)

Coller, Janet Kristie, Barratt, Daniel, Somogyi, Andrew Alexander

Lack of influence of CYP2D6 genotype on the clearance of (R)- (S)- and racemic-methadon (2007)

Coller, Janet Kristie, Joergensen, C., Foster, David John Richard, James, Heather M., Gillis, David, Christrup, L. L., ...

Objective: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. Methods: In this retrospective study, CYP2D6 genotypes were identified in 56...

Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia (2007)

Inglis, Sally Catherine, Herbert, Megan K., Davies, Benjamin James Lloyd, Coller, Janet Kristie, James, Heather M., Horowitz, John David, ...

Sally C. Inglis; Megan K. Herbert; Benjamin J.L. Davies; Janet K. Coller; Heather M. James; John D. Horowitz; Raymond G. Morris; Robert W. Milne; Andrew A. Somogyi; Benedetta C. Sallustio

CYP2B6 CYP2D6 and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes (2007)

Davies, Benjamin James Lloyd, Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

Pharmacogenetics of opioids (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics...

Lack of influence of CYP2D6 genotype on the clearance of (R)- (S)- and racemic-methadon (2007)

Coller, Janet Kristie, Joergensen, C., Foster, David John Richard, James, Heather M., Gillis, David, Christrup, L. L., ...

Objective: To investigate the influence of CYP2D6 genotype on the oral clearance of (R)-, (S)- and rac-methadone. Methods: In this retrospective study, CYP2D6 genotypes were identified in 56...

Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia (2007)

Inglis, Sally Catherine, Herbert, Megan K., Davies, Benjamin James Lloyd, Coller, Janet Kristie, James, Heather M., Horowitz, John David, ...

Sally C. Inglis; Megan K. Herbert; Benjamin J.L. Davies; Janet K. Coller; Heather M. James; John D. Horowitz; Raymond G. Morris; Robert W. Milne; Andrew A. Somogyi; Benedetta C. Sallustio

CYP2B6 CYP2D6 and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes (2007)

Davies, Benjamin James Lloyd, Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, Robert W., Sallustio, Benedetta Cristina

Pharmacogenetics of opioids (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

Opioids are used for acute and chronic pain and dependency. They have a narrow therapeutic index and large interpatient variability in response. Genetic factors regulating their pharmacokinetics...

Pharmacogenetics of opioids [dupe] (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

TGFβ2 and TβRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells (2007)

Buck, Miriam B., Coller, Janet Kristie, Murdter, Thomas E., Eichelbaum, Michel, Knabbe, Cornelius

The original publication can be found at www.springerlink.com

Pharmacogenetics of opioids [dupe] (2007)

Somogyi, Andrew Alexander, Barratt, Daniel, Coller, Janet Kristie

TGFβ2 and TβRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells (2007)

Buck, Miriam B., Coller, Janet Kristie, Murdter, Thomas E., Eichelbaum, Michel, Knabbe, Cornelius

The original publication can be found at www.springerlink.com

Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography (2006)

Davies, B. J., Herbert, M. K., Culbert, J. A., Pyke, Simon Matthew, Coller, Janet Kristie, Somogyi, Andrew Alexander, ...

Association between the DRD2 A(1) allele and response to methadone and buprenorphine maintenance treatments (2006)

Barratt, Daniel, Somogyi, Andrew Alexander, Coller, Janet Kristie

The definitive version is available at www3.interscience.wiley.com.

Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography (2006)

Davies, B. J. L., Herbert, M. K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, R. W., Sallustio, B. C.

The use of perhexiline (PHX) is limited by hepatic and neurological toxicity associated with elevated concentrations in plasma that are the result of polymorphism of the cytochrome P450 2D6 isoform...

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals (2006)

Coller, Janet Kristie, Barratt, Daniel, Dahlen, K., Loennechen, M. H., Somogyi, Andrew Alexander

Background and Objectives: The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable,...

Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography (2006)

Davies, B. J., Herbert, M. K., Culbert, J. A., Pyke, Simon Matthew, Coller, Janet Kristie, Somogyi, Andrew Alexander, ...

Association between the DRD2 A(1) allele and response to methadone and buprenorphine maintenance treatments (2006)

Barratt, Daniel, Somogyi, Andrew Alexander, Coller, Janet Kristie

The definitive version is available at www3.interscience.wiley.com.

Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography (2006)

Davies, B. J. L., Herbert, M. K., Coller, Janet Kristie, Somogyi, Andrew Alexander, Milne, R. W., Sallustio, B. C.

The use of perhexiline (PHX) is limited by hepatic and neurological toxicity associated with elevated concentrations in plasma that are the result of polymorphism of the cytochrome P450 2D6 isoform...

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals (2006)

Coller, Janet Kristie, Barratt, Daniel, Dahlen, K., Loennechen, M. H., Somogyi, Andrew Alexander

Background and Objectives: The most common treatment for opioid dependence is substitution therapy with another opioid such as methadone. The methadone dosage is individualized but highly variable,...

The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia (2005)

Davies, B. J. L., Coller, Janet Kristie, James, H. M., Somogyi, Andrew Alexander, Horowitz, John David, Sallustio, B. C.

The definitive version is available at www.blackwell-synergy.com

The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia (2005)

Davies, B. J. L., Coller, Janet Kristie, James, H. M., Somogyi, Andrew Alexander, Horowitz, John David, Sallustio, B. C.

The definitive version is available at www.blackwell-synergy.com

Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity (2004)

Coller, Janet Kristie, Krebsfaenger, N., Klein, K., Wolbold, R., Nüssler, A., Neuhaus, P., ...

The definitive version is available at www.blackwell-synergy.com

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes (2004)

Hutchinson, Mark R., Menelaou, A., Foster, D. J.R., Coller, Janet Kristie, Somogyi, Andrew Alexander

The definitive version is available at www.blackwell-synergy.com