Jaroslaw Polanski

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity (2009)

Josef Jampilek, Robert Musiol, Matus Pesko, Katarina Kralova, Marcela Vejsova, James Carroll, ...

In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using...

The Use of MoStBioDat for Rapid Screening of Molecular Diversity (2009)

Andrzej Bak, Jaroslaw Polanski, Agata Kurczyk

MoStBioDat is a uniform data storage and extraction system with an extensive array of tools for structural similarity measures and pattern matching which is essential to facilitate the drug discovery...

Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues (2009)

Josef Jampilek, Robert Musiol, Jacek Finster, Matus Pesko, James Carroll, Katarina Kralova, ...

In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The...

Self-organizing Neural Networks for Modeling Robust 3D and 4D QSAR: Application to Dihydrofolate Reductase Inhibitors (2008)

Jaroslaw Polanski, Andrzej Bak, Rafal Gieleciak, Tomasz Magdziarz

Abstract: We have used SOM and grid 3D and 4D QSAR schemes for modeling the activity of a series of dihydrofolate reductase inhibitors. Careful analysis of the performance and external predictivities...

Self-organizing Neural Networks for Modeling Robust 3D and 4D QSAR: Application to Dihydrofolate Reductase Inhibitors (2004)

Jaroslaw Polanski, Andrzej Bak, Rafal Gieleciak, Tomasz Magdziarz

We have used SOM and grid 3D and 4D QSAR schemes for modeling the activity of a series of dihydrofolate reductase inhibitors. Careful analysis of the performance and external predictivities proves...