Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. (2006)
Anning, Peter Brian, Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
Quantification of Isoprostanes as an Index of Oxidative Stress: A Update (2006)
Huiyong Yin, Erik S. Musiek, Jason D. Morrow
Isoprostanes are prostaglandin-like compounds formed from the free radical-catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzymes. The isoprostanes possess potent...
Quantification of Isoprostanes as an Index of Oxidative Stress: A Update (2006)
Huiyong Yin, Erik S. Musiek, Jason D. Morrow
Isoprostanes are prostaglandin-like compounds formed from the free radical-catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzymes. The isoprostanes possess potent...
Fowke, Jay H., Morrow, Jason D., Motley, Saundra, Bostick, Roberd M., Ness, Reid M.
Isothiocyanates and indoles (e.g. indole-3-carbinol) from Brassica vegetables (e.g. broccoli) induce Phase I and Phase II enzymes responsible for the oxidation, reduction and metabolism of endogenous...
Fowke, Jay H., Morrow, Jason D., Motley, Saundra, Bostick, Roberd M., Ness, Reid M.
Isothiocyanates and indoles (e.g., indole-3-carbinol) from Brassica vegetables (e.g., broccoli) induce Phase I and Phase II enzymes responsible for the oxidation, reduction, and metabolism of...
In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets (2005)
Williams, Paula Claire, Coffey, Marcus Jonathan, Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John Ronald, ...
In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets (2005)
Williams, Paula Claire, Coffey, Marcus Jonathan, Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John Ronald, ...
Antiplatelet therapies improve endothelial function in atherosclerosis, suggesting that platelets regulate vascular nitric oxide (NO) bioactivity in vivo. Herein, washed platelets consumed NO on...
Lipids versus Proteins as Major Targets of Pro-Oxidant, Direct-Acting Hemolytic Agents (2005)
McMillan, David C., Powell, Christine L., Bowman, Zachary S., Morrow, Jason D., Jollow, David J.
Lipid peroxidation and the accompanying translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the lipid bilayer have recently been identified as key components of a...
Lipids vs. Proteins as Major Targets of Pro-Oxidant, Direct-Acting Hemolytic Agents (2005)
McMillan, David C., Powell, Christine L., Bowman, Zachary S., Morrow, Jason D., Jollow, David J.
Factors Associated with Oxidative Stress in Human Populations (2002)
Block, Gladys, Dietrich, Marion, Norkus, Edward P., Morrow, Jason D., Hudes, Mark, Caan, Bette, ...
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and the...
Crofford, Leslie J., Oates, James C., McCune, William Joseph, Gupta, Samardeep, Kaplan, Mariana J., Catella-Lawson, Francesca, ...
Specific inhibitors of cyclooxygenase 2 (COX-2) have been approved for the treatment of osteoarthritis and rheumatoid arthritis. Unlike nonsteroidal anti-inflammatory drugs, specific COX-2 inhibitors...
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. (1999)
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia-telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
Reese, Jeff, Paria, Bibhash C., Brown, Naoko, Zhao, Xuemei, Morrow, Jason D., Dey, Sudhansu K.
Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for parturition, whereas...
Terasawa, Yuko, Ladha, Zuleika, Leonard, Scott W., Morrow, Jason D., Newland, Dale, Sanan, David, ...
Although lipid peroxidation in the subendothelial space has been hypothesized to play a central role in atherogenesis, the role of vitamin E in preventing lipid peroxidation and lesion development...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
Qi, Zhonghua, Hao, Chuan-Ming, Langenbach, Robert I., Breyer, Richard M., Redha, Reyadh, Morrow, Jason D., ...
Therapeutic use of cyclooxygenase-inhibiting (COX-inhibiting) nonsteroidal antiinflammatory drugs (NSAIDs) is often complicated by renal side effects including hypertension and edema. The present...
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
Zhonghua, Qi, Hao, Chuan-Ming, Langenbach, Robert I., Breyer, Richard M., Redha, Reyadh, Morrow, Jason D., ...
Yang, Li, Yamagata, Noboru, Yadav, Rajwardhan, Brandon, Suzanne, Courtney, Regina L., Morrow, Jason D., ...
Prostaglandin E2 (PGE2), a major COX metabolite, plays important roles in several facets of tumor biology. We characterized the contribution of the PGE2 EP2 receptor to cancer-associated immune...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Nirodi, Chaitanya S., Crews, Brenda C., Kozak, Kevin R., Morrow, Jason D., Marnett, Lawrence J.
Glyceryl prostaglandins (PG-Gs) are generated by the oxygenation of the endocannabinoid, 2-arachidonylglycerol, by cyclooxygenase 2. The biological consequences of this selective oxygenation are...
Hashimoto, Koichi, Graham, Barney S., Geraci, Mark W., FitzGerald, Garret A., Egan, Karine, Zhou, Weisong, ...
The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I2 (PGI2). Mice that...
Accelerated telomere shortening in response to life stress
Epel, Elissa S., Blackburn, Elizabeth H., Lin, Jue, Dhabhar, Firdaus S., Adler, Nancy E., Morrow, Jason D., ...
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms...
Levonen, Anna-Liisa, Landar, Aimee, Ramachandran, Anup, Ceaser, Erin K, Dickinson, Dale A, Zanoni, Giuseppe, ...
The molecular mechanisms through which oxidized lipids and their electrophilic decomposition products mediate redox cell signalling is not well understood and may involve direct modification of...
Dixon, Dan A., Tolley, Neal D., Bemis-Standoli, Kristi, Martinez, Mark L., Weyrich, Andrew S., Morrow, Jason D., ...
Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets and monocytes...
Saha, Debabrata, Datta, Pran K, Sheng, Hongmiao, Morrow, Jason D, Wada, Michihiko, Moses, Harold L, ...
Increased expression of cyclooxygenase-2 (COX-2) expression has been observed in several human tumor types and in selected animal and cell culture models of carcinogenesis, including lung cancer....
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
Williams, Christopher S, Goldman, Angela P, Sheng, Hongmiao, Morrow, Jason D, DuBois, Raymond N
Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in...
Reese, Jeff, Paria, Bibhash C., Brown, Naoko, Zhao, Xuemei, Morrow, Jason D., Dey, Sudhansu K.
Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for parturition, whereas...
Terasawa, Yuko, Ladha, Zuleika, Leonard, Scott W., Morrow, Jason D., Newland, Dale, Sanan, David, ...
Although lipid peroxidation in the subendothelial space has been hypothesized to play a central role in atherogenesis, the role of vitamin E in preventing lipid peroxidation and lesion development...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
Qi, Zhonghua, Hao, Chuan-Ming, Langenbach, Robert I., Breyer, Richard M., Redha, Reyadh, Morrow, Jason D., ...
Therapeutic use of cyclooxygenase-inhibiting (COX-inhibiting) nonsteroidal antiinflammatory drugs (NSAIDs) is often complicated by renal side effects including hypertension and edema. The present...
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
Zhonghua, Qi, Hao, Chuan-Ming, Langenbach, Robert I., Breyer, Richard M., Redha, Reyadh, Morrow, Jason D., ...
Yang, Li, Yamagata, Noboru, Yadav, Rajwardhan, Brandon, Suzanne, Courtney, Regina L., Morrow, Jason D., ...
Prostaglandin E2 (PGE2), a major COX metabolite, plays important roles in several facets of tumor biology. We characterized the contribution of the PGE2 EP2 receptor to cancer-associated immune...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Nirodi, Chaitanya S., Crews, Brenda C., Kozak, Kevin R., Morrow, Jason D., Marnett, Lawrence J.
Glyceryl prostaglandins (PG-Gs) are generated by the oxygenation of the endocannabinoid, 2-arachidonylglycerol, by cyclooxygenase 2. The biological consequences of this selective oxygenation are...
Hashimoto, Koichi, Graham, Barney S., Geraci, Mark W., FitzGerald, Garret A., Egan, Karine, Zhou, Weisong, ...
The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I2 (PGI2). Mice that...
Accelerated telomere shortening in response to life stress
Epel, Elissa S., Blackburn, Elizabeth H., Lin, Jue, Dhabhar, Firdaus S., Adler, Nancy E., Morrow, Jason D., ...
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms...
Levonen, Anna-Liisa, Landar, Aimee, Ramachandran, Anup, Ceaser, Erin K, Dickinson, Dale A, Zanoni, Giuseppe, ...
The molecular mechanisms through which oxidized lipids and their electrophilic decomposition products mediate redox cell signalling is not well understood and may involve direct modification of...
Saha, Debabrata, Datta, Pran K, Sheng, Hongmiao, Morrow, Jason D, Wada, Michihiko, Moses, Harold L, ...
Increased expression of cyclooxygenase-2 (COX-2) expression has been observed in several human tumor types and in selected animal and cell culture models of carcinogenesis, including lung cancer....
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
Williams, Christopher S, Goldman, Angela P, Sheng, Hongmiao, Morrow, Jason D, DuBois, Raymond N
Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in...
Dixon, Dan A., Tolley, Neal D., Bemis-Standoli, Kristi, Martinez, Mark L., Weyrich, Andrew S., Morrow, Jason D., ...
Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets and monocytes...
Fatty Acid Oxidation in the Pathogenesis of Alzheimer’s Disease
Montine, Thomas J., Morrow, Jason D.
Alzheimer’s disease (AD) is the most common dementing illness of the elderly and is a mounting public health problem. Pharmacoepidemiological data, analytical data from human tissue and body...
Lack of Integrin α1β1 Leads to Severe Glomerulosclerosis after Glomerular Injury
Chen, Xiwu, Moeckel, Gilbert, Morrow, Jason D., Cosgrove, Dominic, Harris, Raymond C., Fogo, Agnes B., ...
Severity of fibrosis after injury is determined by the nature of the injury and host genetic susceptibility. Metabolism of collagen, the major component of fibrotic lesions, is, in part, regulated by...
Montine, Thomas J., Markesbery, William R., Zackert, William, Sanchez, Stephanie C., Roberts, L. Jackson, Morrow, Jason D.
Numerous post mortem studies have demonstrated increased accumulation of lipid peroxidation products in diseased regions of Alzheimer’s disease (AD) brain; however, few have used techniques that...
Reich, Erin E., Markesbery, William R., Roberts, L. Jackson, Swift, Larry L., Morrow, Jason D., Montine, Thomas J.
Isoprostanes (IsoP) are produced exclusively from free radical damage to arachidonic acid, a fatty acid that is evenly distributed throughout white matter and gray matter, whereas neuroprostanes...
Gluais, Pascale, Lonchampt, Michel, Morrow, Jason D, Vanhoutte, Paul M, Feletou, Michel
In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY), acetylcholine releases an endothelium-derived contracting factor (EDCF) produced by endothelial cyclooxygenase-1,...
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
Anning, Peter B., Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
Barger, Jamie L., Kayo, Tsuyoshi, Vann, James M., Arias, Edward B., Wang, Jelai, Hacker, Timothy A., ...
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old...
Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, ...
Cytosolic phospholipase A2α (cPLA2α) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as...
Barger, Jamie L., Kayo, Tsuyoshi, Vann, James M., Arias, Edward B., Wang, Jelai, Hacker, Timothy A., ...
Morton, Jonathan, Coles, Barbara, Wright, Kate, Gallimore, Awen, Morrow, Jason D., Terry, Erin S., ...
Whether leukocytes exert an influence on vascular function in vivo is not known. Here, genetic and pharmacologic approaches show that the absence of neutrophils leads to acute blood pressure...
Barger, Jamie L., Kayo, Tsuyoshi, Vann, James M., Arias, Edward B., Wang, Jelai, Hacker, Timothy A., ...
Barger, Jamie L., Kayo, Tsuyoshi, Vann, James M., Arias, Edward B., Wang, Jelai, Hacker, Timothy A., ...
F2-Dihomo-isoprostanes arise from free radical attack on adrenic acid*
VanRollins, Mike, Woltjer, Randall L., Yin, Huiyong, Morrow, Jason D., Montine, Thomas J.
Unlike F4-neuroprostanes (F4-NeuroPs), which are relatively selective in vivo markers of oxidative damage to neuronal membranes, there currently is no method to assess the extent of free radical...
Brooks, Joshua D., Milne, Ginger L., Yin, Huiyong, Sanchez, Stephanie C., Porter, Ned A., Morrow, Jason D.
Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) found in marine fish oils are known to suppress inflammation associated with a wide variety of diseases. Eicosapentaenoic acid (EPA) is one of the...
Yang, Lichuan, Calingasan, Noel Y., Thomas, Bobby, Chaturvedi, Rajnish K., Kiaei, Mahmoud, Wille, Elizabeth J., ...
The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective...
Dostalek, Miroslav, Hardy, Klarissa D., Milne, Ginger L., Morrow, Jason D., Chen, Chi, Gonzalez, Frank J., ...
Reactive oxygen species (ROS) and oxidative stress have been considered in a variety of disease models, and cytochrome P450 (P450) enzymes have been suggested to be a source of ROS. Induction of...
Musiek, Erik S., Brooks, Joshua D., Joo, Myungsoo, Brunoldi, Enrico, Porta, Alessio, Zanoni, Giuseppe, ...
The ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) possesses potent anti-inflammatory properties and has shown therapeutic benefit in numerous inflammatory diseases. However, the...